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This systematic review performed in accordance with PRISMA guidelines aimed to identify studies that determined (a)\u00a0the physiological and metabolic demands of CrossFit<jats:sup>\u00ae<\/jats:sup> and (b)\u00a0the effects of nutritional strategies on CrossFit<jats:sup>\u00ae<\/jats:sup> performance to guide nutritional recommendations for optimal recovery, adaptations, and performance for CrossFit<jats:sup>\u00ae<\/jats:sup> athletes and direct future research in this emerging area. Three databases were searched for studies that investigated physiological responses to CrossFit<jats:sup>\u00ae<\/jats:sup> and dietary or supplementation interventions on CrossFit<jats:sup>\u00ae<\/jats:sup> performance. Various physiological measures revealed the intense nature of all CrossFit<jats:sup>\u00ae<\/jats:sup> workouts of the day, reflected in substantial muscle fatigue and damage. Dietary and supplementation studies provided an unclear insight into effective strategies to improve performance and enhance adaptations and recovery due to methodological shortcomings across studies. This systematic review showed that CrossFit<jats:sup>\u00ae<\/jats:sup> is a high-intensity sport with fairly homogenous anaerobic and aerobic characteristics, resulting in substantial metabolic stress, leading to metabolite accumulation (e.g.,\u00a0lactate and hydrogen ions) and increased markers of muscle damage and muscle fatigue. Limited interventional data exist on dietary and supplementation strategies to optimize CrossFit<jats:sup>\u00ae<\/jats:sup> performance, and most are moderate to very low quality with some critical methodological limitations, precluding solid conclusions on their efficacy. High-quality work is needed to confirm the ideal dietary and supplemental strategies for optimal performance and recovery for CrossFit<jats:sup>\u00ae<\/jats:sup> athletes and is an exciting avenue for further research.<\/jats:p>","DOI":"10.1123\/ijsnem.2020-0223","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T06:31:18Z","timestamp":1611901878000},"page":"187-205","source":"Crossref","is-referenced-by-count":28,"title":["A Systematic Review of CrossFit\u00ae Workouts and Dietary and Supplementation Interventions to Guide Nutritional Strategies and Future Research in CrossFit\u00ae"],"prefix":"10.1123","volume":"31","author":[{"given":"Ricardo Augusto Silva","family":"de Souza","sequence":"first","affiliation":[{"name":"University of Lavras"},{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Guedes","family":"da Silva","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda Ferreira","family":"de Souza","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Kataryne Ferreira","family":"Souza","sequence":"additional","affiliation":[{"name":"University of Lavras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamilton","family":"Roschel","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro Fernandes","family":"da Silva","sequence":"additional","affiliation":[{"name":"University of Lavras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Saunders","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"100","reference":[{"key":"r1","series-title":"Mitochondrion,","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.mito.2014.05.007","article-title":"Comprehensive review on lactate metabolism in human health","volume":"17,","author":"Adeva-Andany, M.","year":"2014","unstructured":"Adeva-Andany, M., Lopez-Ojen, M., Funcasta-Calderon, R., Ameneiros-Rodriguez, E., Donapetry-Garcia, C., Vila-Altesor, M., & Rodriguez-Seijas, J. 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