{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:00:59Z","timestamp":1793062859214,"version":"4.5.0"},"reference-count":74,"publisher":"Human Kinetics","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:p>The aim of this systematic review was to examine the effects of physical exercise training on cerebral blood flow (CBF), which is a physiological marker of cerebrovascular function. Relationships between training-induced effects on CBF with changes in cognitive performance were also discussed. A systematic search was performed up to July 2022. Forty-five intervention studies with experimental, quasi-experimental, or pre\u2013post designs were included. Sixteen studies (median duration: 14\u00a0weeks) investigated effects of physical exercise training on CBF markers using magnetic resonance imaging, 20 studies (median duration: 14\u00a0weeks) used transcranial Doppler ultrasound, and eight studies (median duration: 8\u00a0weeks) used near-infrared spectroscopy. Studies using magnetic resonance imaging observed consistent increases in CBF in the anterior cingulate cortex and hippocampus, but not in whole-brain CBF. Effects on resting CBF\u2014measured with transcranial Doppler ultrasound and near-infrared spectroscopy\u2014were variable, while middle cerebral artery blood flow velocity increased in some studies following exercise or hypercapnic stimuli. Interestingly, concomitant changes in physical fitness and regional CBF were observed, while a relation between training-induced effects on CBF and cognitive performance was evident. In conclusion, exercise training improved cerebrovascular function because regional CBF was changed. Studies are however still needed to establish whether exercise-induced improvements in CBF are sustained over longer periods of time and underlie the observed beneficial effects on cognitive performance.<\/jats:p>","DOI":"10.1123\/ijsnem.2022-0085","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T04:40:22Z","timestamp":1664340022000},"page":"47-59","source":"Crossref","is-referenced-by-count":45,"title":["Effects of Physical Exercise Training on Cerebral Blood Flow Measurements: A Systematic Review of Human Intervention Studies"],"prefix":"10.1123","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-9656","authenticated-orcid":true,"given":"Jordi P.D.","family":"Kleinloog","sequence":"first","affiliation":[{"name":"Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4809-554X","authenticated-orcid":true,"given":"Kevin M.R.","family":"Nijssen","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8908-3580","authenticated-orcid":true,"given":"Ronald P.","family":"Mensink","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-5776","authenticated-orcid":true,"given":"Peter J.","family":"Joris","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"100","reference":[{"issue":"3","key":"r1","series-title":"Artery Research,","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.artres.2012.05.003","article-title":"Aerobic exercise training increases cerebral blood flow in postmenopausal women","volume":"6","author":"Akazawa, N.","year":"2012","unstructured":"Akazawa, N., Choi, Y., Miyaki, A., Sugawara, J., Ajisaka, R., & Maeda, S. 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