{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:11:20Z","timestamp":1747188680423,"version":"3.40.5"},"reference-count":53,"publisher":"Human Kinetics","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:p><jats:italic><jats:bold>Objective<\/jats:bold>:<\/jats:italic> To determine whether statin medication in individuals with obesity, dyslipidemia, and metabolic syndrome affects their capacity to mobilize and oxidize fat during exercise. <jats:italic><jats:bold>Methods<\/jats:bold>:<\/jats:italic> Twelve individuals with metabolic syndrome pedaled during 75\u00a0min at 54\u2009\u00b1\u200913% <jats:inline-formula\/> (5.7\u2009\u00b1\u20090.5 metabolic equivalents) while taking statins (STATs) or after 96-hr statin withdrawal (PLAC) in a randomized double-blind fashion. <jats:italic><jats:bold>Results<\/jats:bold>:<\/jats:italic> At rest, PLAC increased low-density lipoprotein cholesterol (i.e.,\u00a0STAT 2.55\u2009\u00b1\u20090.96 vs. PLAC 3.16\u2009\u00b1\u20090.76\u00a0mmol\/L; <jats:italic>p<\/jats:italic>\u2009=\u2009.004) and total cholesterol blood levels (i.e.,\u00a0STAT 4.39\u2009\u00b1\u20091.16 vs. PLAC 4.98\u2009\u00b1\u20090.97\u00a0mmol\/L; <jats:italic>p<\/jats:italic>\u2009=\u2009.008). At rest, fat oxidation (0.99\u2009\u00b1\u20090.34 vs. 0.76\u2009\u00b1\u20090.37\u00a0\u03bcmol\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> for STAT vs. PLAC; <jats:italic>p<\/jats:italic>\u2009=\u2009.068) and the rates of plasma appearance of glucose and glycerol (i.e.,\u00a0Ra glucose\u2013glycerol) were not affected by PLAC. After 70\u00a0min of exercise, fat oxidation was similar between trials (2.94\u2009\u00b1\u20091.56 vs. 3.06\u2009\u00b1\u20091.94\u00a0\u03bcmol\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>, STA vs. PLAC; <jats:italic>p<\/jats:italic>\u2009=\u2009.875). PLAC did not alter the rates of disappearance of glucose in plasma during exercise (i.e.,\u00a023.9\u2009\u00b1\u20096.9 vs. 24.5\u2009\u00b1\u20098.2\u00a0\u03bcmol\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> for STAT vs. PLAC; <jats:italic>p<\/jats:italic>\u2009=\u2009.611) or the rate of plasma appearance of glycerol (i.e.,\u00a08.5\u2009\u00b1\u20091.9 vs. 7.9\u2009\u00b1\u20091.8\u00a0\u03bcmol\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> for STAT vs. PLAC; <jats:italic>p<\/jats:italic>\u2009=\u2009.262). <jats:italic><jats:bold>Conclusions<\/jats:bold>:<\/jats:italic> In patients with obesity, dyslipidemia, and metabolic syndrome, statins do not compromise their ability to mobilize and oxidize fat at rest or during prolonged, moderately intense exercise (i.e.,\u00a0equivalent to brisk walking). In these patients, the combination of statins and exercise could help to better manage their dyslipidemia.<\/jats:p>","DOI":"10.1123\/ijsnem.2022-0175","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T15:02:04Z","timestamp":1676991724000},"page":"151-160","source":"Crossref","is-referenced-by-count":2,"title":["Chronic Statin Treatment Does Not Impair Exercise Lipolysis or Fat Oxidation in Exercise-Trained Individuals With Obesity and Dyslipidemia"],"prefix":"10.1123","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-8230","authenticated-orcid":true,"given":"Laura","family":"Alvarez-Jimenez","sequence":"first","affiliation":[{"name":"Exercise Physiology Laboratory at Toledo, University of Castilla-La Mancha, Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5117-425X","authenticated-orcid":true,"given":"Alfonso","family":"Moreno-Caba\u00f1as","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory at Toledo, University of Castilla-La Mancha, Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-8592","authenticated-orcid":true,"given":"Felix","family":"Morales-Palomo","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory at Toledo, University of Castilla-La Mancha, Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory at Toledo, University of Castilla-La Mancha, Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-4933","authenticated-orcid":true,"given":"Ricardo","family":"Mora-Rodriguez","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory at Toledo, University of Castilla-La Mancha, Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"issue":"16","key":"r1","series-title":"Circulation,","first-page":"1640","article-title":"Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti, K.G.","year":"2009","unstructured":"Alberti, K.G., Eckel, R.H., Grundy, S.M., Zimmet, P.Z., Cleeman, J.I., Donato, K.A., & International Association for the Study of Obesity. 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