{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:30:26Z","timestamp":1792467026507,"version":"4.5.0"},"reference-count":60,"publisher":"Human Kinetics","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:p>\n                    Exercise perturbs various aspects of gastrointestinal integrity and function, which may lead to performance impeding gastrointestinal symptoms (GIS) and\/or precipitate clinical issues warranting medical management. This study aimed to determine the impact of prebiotic supplementation on gastrointestinal integrity and functional status in response to exertional heat stress (EHS). Sixteen endurance athletes completed two trials of 3-hr running at 60%\n                    <jats:inline-formula\/>\n                    in 30\u00a0\u00b0C at baseline (T1) and following an 8-week supplementation period (T2), with 16\u00a0g\/day prebiotic (PREBIOTIC) or matched placebo (PLACEBO). Blood samples were collected pre-EHS and post-EHS and in recovery for determination of stress response (cortisol), intestinal epithelial injury (intestinal fatty acid binding protein), bacterial endotoxemia (sCD14), and systemic inflammation (C-reactive protein). GIS and feeding tolerance variables were assessed throughout the EHS. Orocecal transit time was determined via a lactulose challenge given at 2.5\u00a0hr into EHS. Plasma cortisol (combined mean: +252\u00a0ng\/ml), intestinal fatty acid binding protein (+800\u00a0pg\/ml), and sCD14 (+487\u00a0ng\/ml) concentrations increased in response to EHS in T1 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u2009.05), but not for C-reactive protein (+0.8\u00a0\u03bcg\/ml;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.05), in both PREBIOTIC and PLACEBO. PREBIOTIC supplementation resulted in a blunted intestinal fatty acid binding protein response on T2 (+316\u00a0pg\/ml) compared with an increase (+1,001\u00a0ng\/ml) in PLACEBO (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.005). Lower sCD14 was observed at T2 (2,799\u00a0ng\/ml) versus T1 (3,246\u00a0ng\/ml) in PREBIOTIC only (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.039). No intervention effects were observed for C-reactive protein. No difference within or between PREBIOTIC and PLACEBO at T1 and T2 was observed for orocecal transit time, GIS, and feeding tolerance. In conclusion, 8 weeks of prebiotic supplementation modestly attenuates EHS associated perturbations to intestinal integrity, but does not further impair gastrointestinal transit and\/or exacerbate EHS associated GIS or feeding tolerance.\n                  <\/jats:p>","DOI":"10.1123\/ijsnem.2024-0127","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T05:22:09Z","timestamp":1740547329000},"page":"273-290","source":"Crossref","is-referenced-by-count":10,"title":["The Effects of Prebiotic Supplementation on Markers of Exercise-Induced Gastrointestinal Syndrome in Response to Exertional Heat Stress"],"prefix":"10.1123","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-1294","authenticated-orcid":true,"given":"Christopher E.","family":"Rauch","sequence":"first","affiliation":[{"name":"Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0289-7857","authenticated-orcid":true,"given":"Kayla","family":"Henningsen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-5409","authenticated-orcid":true,"given":"Isabel","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-604X","authenticated-orcid":true,"given":"Pascale","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-8329","authenticated-orcid":true,"given":"Alice","family":"Mika","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoya","family":"Huschtscha","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Science, Deakin University, Burwood, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-8329","authenticated-orcid":true,"given":"Alan","family":"McCubbin","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Henry","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Clayton, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doville","family":"Anderson","sequence":"additional","affiliation":[{"name":"Monash Proteomics and Metabolomics Platform, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3069-486X","authenticated-orcid":true,"given":"Ricardo J.S.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"100","reference":[{"issue":"11","key":"r1","series-title":"European Journal of Clinical Microbiology & Infectious Diseases,","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1007\/s10096-016-2726-5","article-title":"Pathogen-induced secretory diarrhea and its prevention","volume":"35","author":"Anand, S.","year":"2016","unstructured":"Anand, S., Mandal, S., Patil, P., & Tomar, S. 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