{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T20:28:36Z","timestamp":1767644916675,"version":"3.48.0"},"reference-count":106,"publisher":"Human Kinetics","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    This study aimed to evaluate the effects of short-term oral L-arginine (ARG) supplementation on vascular parameters, nitric oxide (NO) concentration, and muscular performance during upper limb resistance exercise in healthy young men. A randomized, double-blind, crossover design was used with 16 recreationally trained men. Participants ingested ARG (3.2\u20139.6\u00a0g\/day) or placebo for 4 days, separated by a 14-day washout. On the fourth day, they completed three sets of biceps curls at 65% of one-repetition maximum to concentric failure. Primary outcomes included total repetitions performed and fatigue ratio. Secondary outcomes comprised brachial artery diameter, peak systolic velocity, blood flow (velocity\u2013time integral), vascular resistance index, plasma NO, and blood lactate concentrations. No significant differences were observed between ARG and placebo in muscular endurance (total repetitions,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.305), volume load, or fatigue ratio. Plasma NO levels did not differ between conditions (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.522). Although brachial artery diameter significantly increased 1-min postexercise in the ARG condition compared with placebo (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.023), no differences were found for velocity\u2013time integral, peak systolic velocity, resistance index, or blood pressure. Blood lactate concentrations rose after exercise in both groups, with a nonsignificant value in the ARG condition (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.09 at 9-min postexercise). Short-term oral ARG supplementation did not enhance muscular endurance, systemic NO concentration, or vascular function during upper limb resistance exercise in healthy young men. Although a minor increase in brachial artery dilation was observed shortly after exercise, the effect was transient and insufficient to support meaningful ergogenic benefits.\n                  <\/jats:p>","DOI":"10.1123\/ijsnem.2025-0125","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T18:45:27Z","timestamp":1763405127000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study"],"prefix":"10.1123","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-9906","authenticated-orcid":true,"given":"Cezimar Correia","family":"Borges","sequence":"first","affiliation":[{"name":"Goi\u00e1s State University\u2014UEG, An\u00e1polis, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7677-4710","authenticated-orcid":true,"given":"Weder","family":"Alves da Silva","sequence":"additional","affiliation":[{"name":"Human Movement and Rehabilitation, Evangelical University of Goias, An\u00e1polis, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-4231","authenticated-orcid":true,"given":"Alberto Souza","family":"de S\u00e1 Filho","sequence":"additional","affiliation":[{"name":"Human Movement and Rehabilitation, Evangelical University of Goias, An\u00e1polis, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7285-2742","authenticated-orcid":true,"given":"Vicente","family":"Aprigliano","sequence":"additional","affiliation":[{"name":"Escuela de Ingenier\u00eda de Construcci\u00f3n y Transporte, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9354-1460","authenticated-orcid":true,"given":"Pedro Augusto","family":"Inacio","sequence":"additional","affiliation":[{"name":"Human Movement and Rehabilitation, Evangelical University of Goias, An\u00e1polis, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3363-8983","authenticated-orcid":true,"given":"Marina","family":"Silveira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Investigaci\u00f3n en Ciencias del Movimiento, Universidad Arturo Prat, Iquique, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-6576","authenticated-orcid":true,"given":"Gerson","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia, Chile"},{"name":"Escuela de Ciencias de la Actividad F\u00edsica, el Deporte y la Salud, Universidad de Santiago de Chile (USACH), Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"issue":"2","key":"r2","series-title":"Atherosclerosis,","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0021-9150(96)06044-3","article-title":"Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease","volume":"129","author":"Adams, M.R.","year":"1997","unstructured":"Adams, M.R., McCredie, R., Jessup, W., Robinson, J., Sullivan, D., & Celermajer, D.S. 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