{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:26:05Z","timestamp":1770967565487,"version":"3.50.1"},"reference-count":0,"publisher":"Human Kinetics","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:sec sec-type=\"purpose\"><jats:title>Purpose:<\/jats:title><jats:p>Conjugated linoleic acid (CLA) has been reported to modify the inflammatory response associated with allergic airway disease, primarily in animal models. To extend these observations to humans, the effect of short-term CLA supplementation on the severity of exercise-induced bronchoconstriction (EIB) was investigated in asthmatics.<\/jats:p><\/jats:sec><jats:sec sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>Six subjects with physician-diagnosed asthma and EIB began the study on their usual diet, to which was added 4.8 g CLA\/d for 8 wk. Pulmonary-function tests were administered before and after eucapnic voluntary hyperventilation (EVH) challenge at the commencement (Week 0) and conclusion of the treatment period (Week 8). Pre- and 90 min post-EVH challenge, urine was assayed for the presence of cysteinyl leukotrienes (LT) C<jats:sub>4<\/jats:sub>\u2212E<jats:sub>4<\/jats:sub> and 9\u03b1,11\u03b2-prostaglandin (PG) F<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>Pre- to post- EVH forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>) did not significantly differ (<jats:italic>p<\/jats:italic> &gt; .05) from Week 8 to Week 0. The pre- to post-EVH decline in FEV<jats:sub>1<\/jats:sub> at Week 8 (\u201329.6% \u00b1 6.6%) was not significantly different (<jats:italic>p<\/jats:italic> &gt; .05) from that at Week 0 (\u201332.0% \u00b1 5.5%). Area under the curve of FEV<jats:sub>1<\/jats:sub> plotted against time from zero to 60 min (AUC<jats:sub>0\u201360<\/jats:sub>) was unaltered at Week 8 (\u2013931% \u00b1 350% change per minute) compared with Week 0 (\u22121,090% \u00b1 270% change per minute). CLA supplementation did not alter forced midexpiratory flow, forced vital capacity (FVC), or FEV<jats:sub>1<\/jats:sub>\/FVC. In addition, post-EVH urinary LTC<jats:sub>4<\/jats:sub>\u2013E<jats:sub>4<\/jats:sub> and 9\u03b1,11\u03b2-PGF<jats:sub>2<\/jats:sub> were unchanged after CLA supplementation.<\/jats:p><\/jats:sec><jats:sec sec-type=\"conclusion\"><jats:title>Conclusion:<\/jats:title><jats:p>Daily supplementation of 4.8 g CLA for 8 wk does not attenuate airway inflammation or hyperpnea-induced bronchoconstriction in asthmatic individuals.<\/jats:p><\/jats:sec>","DOI":"10.1123\/ijsnem.21.1.40","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T12:34:30Z","timestamp":1470832470000},"page":"40-47","source":"Crossref","is-referenced-by-count":8,"title":["Conjugated Linoleic Acid\u2019s Lack of Attenuation of Hyperpnea-Induced Bronchoconstriction in Asthmatic Individuals in the Short Term"],"prefix":"10.1123","volume":"21","author":[{"given":"Jonathon L.","family":"Stickford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy D.","family":"Mickleborough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyce D.","family":"Fly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Stager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","container-title":["International Journal of Sport Nutrition and Exercise Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/ijsnem\/21\/1\/article-p40.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.humankinetics.com\/downloadpdf\/journals\/ijsnem\/21\/1\/article-p40.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.humankinetics.com\/downloadpdf\/journals\/ijsnem\/21\/1\/article-p40.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T01:00:01Z","timestamp":1724288401000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/ijsnem\/21\/1\/article-p40.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1123\/ijsnem.21.1.40","relation":{},"ISSN":["1526-484X","1543-2742"],"issn-type":[{"value":"1526-484X","type":"print"},{"value":"1543-2742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}