{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:51:39Z","timestamp":1783698699871,"version":"3.55.0"},"reference-count":0,"publisher":"Human Kinetics","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>The flavonoid quercetin is purported to have potent antioxidant and anti-inflammatory properties. This study examined if quercetin supplementation attenuates indicators of exercise-induced muscle damage in a doubleblind laboratory study. Thirty healthy subjects were randomized to quercetin (QU) or placebo (PL) supplementation and performed 2 separate sessions of 24 eccentric contractions of the elbow flexors. Muscle strength, soreness, resting arm angle, upper arm swelling, serum creatine kinase (CK) activity, plasma quercetin (PQ), interleukin-6 (IL-6), and C-reactive protein (CRP) were assessed before and for 5 d after exercise. Subjects then ingested nutrition bars containing 1,000 mg\/d QU or PL for 7 d before and 5 d after the second exercise session, using the opposite arm. PQ reached 202 \u00b1 52 ng\/ml after 7 d of supplementation and remained elevated during the 5-d postexercise recovery period (<jats:italic>p<\/jats:italic> &lt; .05). Subjects experienced strength loss (peak = 47%), muscle soreness (peak = 39 \u00b1 6 mm), reduced arm angle (\u20137\u00b0 \u00b1 1\u00b0), CK elevations (peak = 3,307 \u00b1 1,481 U\/L), and arm swelling (peak = 11 \u00b1 2 mm; <jats:italic>p<\/jats:italic> &lt; .0001), indicating muscle damage and inflammation; however, differences between treatments were not detected. Eccentric exercise did not alter plasma IL-6 (peak = 1.9 pg\/ml) or CRP (peak = 1.6 mg\/L) relative to baseline or by treatment. QU supplementation had no effect on markers of muscle damage or inflammation after eccentric exercise of the elbow flexors.<\/jats:p>","DOI":"10.1123\/ijsnem.22.6.430","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T12:32:46Z","timestamp":1470832366000},"page":"430-437","source":"Crossref","is-referenced-by-count":57,"title":["Effects of Quercetin Supplementation on Markers of Muscle Damage and Inflammation after Eccentric Exercise"],"prefix":"10.1123","volume":"22","author":[{"given":"Kevin S.","family":"O\u2019Fallon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diksha","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozena","family":"Michniak-Kohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Patrick","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Zambraski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla M.","family":"Clarkson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"100","container-title":["International Journal of Sport Nutrition and Exercise Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/ijsnem\/22\/6\/article-p430.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.humankinetics.com\/downloadpdf\/journals\/ijsnem\/22\/6\/article-p430.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.humankinetics.com\/downloadpdf\/journals\/ijsnem\/22\/6\/article-p430.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:12:02Z","timestamp":1724292722000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/ijsnem\/22\/6\/article-p430.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1123\/ijsnem.22.6.430","relation":{},"ISSN":["1526-484X","1543-2742"],"issn-type":[{"value":"1526-484X","type":"print"},{"value":"1543-2742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}