{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:23:10Z","timestamp":1762431790183},"reference-count":42,"publisher":"Human Kinetics","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"Purpose<\/jats:bold>:<\/jats:italic> Ingestion of sildenafil citrate has performance-enhancing effects at high altitudes above 3800\u00a0m in able-bodied individuals. It is unknown whether it can improve the performance of athletes with spinal cord injury (SCI) at moderate altitudes (<2200\u00a0m), relevant to Paralympic competitions. As most men with SCI suffer from erectile dysfunction of neurologic origin and use sildenafil on a regular basis, it seems important to study the impact of sildenafil on exercise capacity. The outcome of this study is also relevant to the antidoping community. Methods<\/jats:bold>:<\/jats:italic> Twenty-seven healthy male wheelchair athletes with a motor-complete SCI participated in this prospective double-blind, randomized, placebo-controlled study. The participants performed arm cranking exercise to exhaustion at sea level and moderate altitude (2200\u00a0m) after ingestion of 50 mg sildenafil citrate or a placebo. Peak power output, peak oxygen uptake, peak heart rate, rating of perceived exertion, oxygen saturation, and lactate concentrations at exhaustion were measured. Results<\/jats:bold>:<\/jats:italic> Friedman analysis showed that peak power output at sea level was significantly higher (P<\/jats:italic>\u2009=\u2009.004) under placebo treatment (median [minimum; maximum]: 120\u00a0W [35; 170]) compared with sildenafil (115\u00a0W [40; 165]). Blood oxygen saturation under sildenafil treatment at sea level (98% [81; 100]) was significantly higher (P<\/jats:italic>\u2009=\u2009.006) compared with sildenafil treatment at moderate altitude (94% [85; 100]). All other parameters revealed no impact of sildenafil or altitude. Conclusions<\/jats:bold>:<\/jats:italic> In this study, the ingestion of sildenafil citrate in athletes with SCI demonstrated no positive effects on peak arm-cranking-exercise capacity compared with placebo either at sea level or at moderate altitude.<\/jats:p>","DOI":"10.1123\/ijspp.2019-0421","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T04:07:41Z","timestamp":1584331661000},"page":"971-975","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Sildenafil Citrate on Exercise Capacity in Athletes With Spinal Cord Injury"],"prefix":"10.1123","volume":"15","author":[{"given":"Claudio","family":"Perret","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"Van 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