{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:45:28Z","timestamp":1781833528968,"version":"3.54.5"},"reference-count":54,"publisher":"Human Kinetics","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p><jats:italic><jats:bold>Background<\/jats:bold>:<\/jats:italic> Patients with heart failure (HF) experience a marked reduction in overall skeletal muscle strength and exercise capacity, which is detrimental to their prognosis. This study examined the clinical implications of handgrip strength (HGS) in patients with HF. <jats:italic><jats:bold>Methods<\/jats:bold>:<\/jats:italic> Overall, 173 patients (mean age, 62\u00a0years; 81.5% male) underwent cardiac rehabilitation from 2015 to 2020. Baseline HGS was measured as the average value (kg) for both hands using a handheld dynamometer. For each patient, distance walked during a 6-min walk test and metabolic equivalents were recorded. The primary outcome was the composite of readmissions for HF and all-cause death. <jats:italic><jats:bold>Results<\/jats:bold>:<\/jats:italic> Receiver operating characteristic curve for the primary outcome revealed 24.9\u00a0kg as the HGS cutoff point (area under curve: 0.702, 95% confidence interval [0.610, 0.794], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and multivariable Cox proportional hazard analysis revealed that lower HGS was significantly associated with a higher risk of readmission for HF or all-cause death (hazard ratio\u00a0[HR]\u00a06.44, 95% confidence interval [2.86, 14.50], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). This result is mainly attributed to the increased risk of readmission for HF in this group (hazard ratio 6.75, 95% confidence interval [2.87, 15.88], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Moreover, HGS was significantly positively correlated with distance on 6-min walk test (<jats:italic>r<\/jats:italic>\u2009=\u2009.564, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and metabolic equivalents (<jats:italic>r<\/jats:italic>\u2009=\u2009.419, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and is one of the strongest predictors of each exercise capacity category. <jats:italic><jats:bold>Conclusions<\/jats:bold>:<\/jats:italic> As our findings suggested, HGS is an indicator of exercise capacity and a useful marker for predicting hospital readmission or all-cause death in patients with HF.<\/jats:p>","DOI":"10.1123\/japa.2023-0298","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T13:57:46Z","timestamp":1741183066000},"page":"506-516","source":"Crossref","is-referenced-by-count":2,"title":["Association of Handgrip Strength With Readmission, Mortality, and Exercise Capacity in Patients With Heart Failure"],"prefix":"10.1123","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-2002","authenticated-orcid":true,"given":"Soohyung","family":"Park","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5630-1449","authenticated-orcid":true,"given":"Se hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Sport Medicine Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-6568","authenticated-orcid":true,"given":"Jieun","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-855X","authenticated-orcid":true,"given":"You-Jung","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5187-8310","authenticated-orcid":true,"given":"Dong Oh","family":"Kang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-3508","authenticated-orcid":true,"given":"Eun Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6793-4137","authenticated-orcid":true,"given":"Jah Yeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-9079","authenticated-orcid":true,"given":"Seung-Young","family":"Roh","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-3007","authenticated-orcid":true,"given":"Dae-In","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Division of Cardiology, Department of 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