{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T05:09:43Z","timestamp":1794114583930,"version":"4.8.0"},"reference-count":125,"publisher":"Human Kinetics","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"\n \n Objective<\/jats:bold>\n :\n <\/jats:italic>\n The aim of this paper was to undertake a Preferred Reporting Items for Systematic Reviews and Meta-Analysis-accordant meta-analysis comparing exercise-induced muscle damage (EIMD) in older and younger adults.\n \n Methods<\/jats:bold>\n :\n <\/jats:italic>\n Google Scholar, PubMed, and SPORTDiscus were searched in June 2023 for the terms \u201cageing\u201d OR \u201cage\u201d OR \u201cmiddle-aged\u201d OR \u201cold\u201d OR \u201colder\u201d OR \u201celderly\u201d OR \u201cmasters\u201d OR \u201cveteran\u201d AND \u201cmuscle damage\u201d OR \u201cexercise-induced muscle damage\u201d OR \u201cexercise-induced muscle injury\u201d OR \u201ccontraction-induced injury\u201d OR \u201cmuscle soreness\u201d OR \u201cdelayed onset muscle soreness\u201d OR \u201ccreatine kinase.\u201d From 1,092 originally identified titles, 36 studies were included which had an exercise component comparing a younger against an older group. The outcome variables of EIMD were muscle function, muscle soreness, and creatine kinase. A meta-analysis was conducted on change to EIMD after exercise in older versus younger adults using standardized mean difference (SMD) and an inverse-variance random effects model.\n \n Results<\/jats:bold>\n :\n <\/jats:italic>\n Change after 24 and 72\u00a0hr, and peak change, in muscle function was not different between old and young (SMD range\u2009=\u2009\u22120.16 to \u22120.35). Muscle soreness was greater in younger than older adults for all comparisons (SMD range\u2009=\u2009\u22120.34 to \u22120.62). Creatine kinase was greater in younger than older adults at 24\u00a0hr (SMD\u2009=\u2009\u22120.32), as was peak change (SMD\u2009=\u2009\u22120.32). A relationship between sex and peak muscle function change was evident for males (SMD\u2009=\u2009\u22120.45), but not females (SMD\u2009=\u2009\u22120.44). All other meta-regression was nonsignificant.\n \n Conclusion<\/jats:bold>\n :\n <\/jats:italic>\n Advancing age is not associated with greater symptoms of EIMD. The implication of this study is that the older adults can pursue regular physical activity without concern for experiencing greater EIMD.\n <\/jats:p>","DOI":"10.1123\/japa.2024-0165","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T10:01:53Z","timestamp":1743588113000},"page":"606-624","source":"Crossref","is-referenced-by-count":1,"title":["Advancing Age Is Not Associated With Greater Exercise-Induced Muscle Damage: A Systematic Review, Meta-Analysis, and Meta-Regression"],"prefix":"10.1123","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0843-508X","authenticated-orcid":true,"given":"John F.T.","family":"Fernandes","sequence":"first","affiliation":[{"name":"School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-6132","authenticated-orcid":true,"given":"Laura J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"London Sport Institute, Middlesex University, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia F.","family":"Dingley","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Brunel University, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-9158","authenticated-orcid":true,"given":"Andrew N.","family":"Hearn","sequence":"additional","affiliation":[{"name":"Department of HE Sport, Hartpury University, Hartpury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-5129","authenticated-orcid":true,"given":"Kelsie O.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Research Institute of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-9191","authenticated-orcid":true,"given":"Kirsty M.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle, United Kingdom"},{"name":"Washington Spirit, Columbia, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6168-0378","authenticated-orcid":true,"given":"Craig","family":"Twist","sequence":"additional","affiliation":[{"name":"Research Institute of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-0072","authenticated-orcid":true,"given":"Lawrence D.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Lancaster Medical School, Lancaster University, Lancaster, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"100","reference":[{"issue":"1","key":"r1","series-title":"Journal of Sports Science and Medicine,","first-page":"145","article-title":"Age-related, site-specific muscle loss in 1507 Japanese men and women aged 20 to 95\u00a0years","volume":"10","author":"Abe, T.","year":"2011","unstructured":"Abe, T., Sakamaki, M., Yasuda, T., Bemben, M.G., Kondo, M., Kawakami, Y., & Fukunaga, T. 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