{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:26:00Z","timestamp":1794018360146,"version":"4.8.0"},"reference-count":49,"publisher":"Human Kinetics","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>\n                    <jats:italic>\n                      <jats:bold>Background\/Objectives<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    Women 65 and older experience nearly three-fourths of the 2 million osteoporotic fractures annually in the United States. We investigated associations of accelerometer-measured total physical activity, light physical activity, moderate-to-vigorous physical activity (MVPA), steps, total sitting time, and mean sitting bout duration with incident osteoporotic fracture.\n                    <jats:italic>\n                      <jats:bold>Methods<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    Women from the Objective Physical Activity and Cardiovascular Health cohort (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20096,122; mean age: 78.7;\n                    <jats:italic>SD<\/jats:italic>\n                    : 6.7) without prior hip fracture wore the ActiGraph GT3X+ up to 7\u00a0days and were followed up to 8\u00a0years for incident osteoporotic fractures (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009982). Cox regression models estimated hazard ratios and 95% confidence intervals (CI) additionally containing age, race\/ethnicity, education, alcohol, smoking, height, weight, falls, physical functioning, diabetes, thiazide use, and anti-osteoporosis medication use.\n                    <jats:italic>\n                      <jats:bold>Results<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    Multivariable HRs (95% CI) were 1 (ref), 1.10 [0.93, 1.31], 0.93 [0.77, 1.13], and 0.87 [0.70, 1.07] across MVPA minutes\/quartiles (\n                    <jats:italic>p<\/jats:italic>\n                    -trend\u2009=\u2009.03) and 1 (ref), 1.10 [0.90, 1.33], 1.21 [1.00, 1.47], and 1.27 [1.04, 1.57] across total sitting time quartiles (\n                    <jats:italic>p<\/jats:italic>\n                    -trend\u2009=\u2009.02). The hazard ratios (95% CI) for a one-\n                    <jats:italic>SD<\/jats:italic>\n                    increment in MVPA (33\u00a0min\/day) and total sitting time (103\u00a0min\/day) were 0.92 [0.85, 0.99] and 1.09 [1.01, 1.18], respectively. The hazard ratios (95% CI) for MVPA and osteoporotic fracture was 0.82 [0.73, 0.93] among women not using anti-osteoporosis medication and 1.06 [0.90, 1.24] among women using anti-osteoporosis medication (\n                    <jats:italic>p<\/jats:italic>\n                    -interaction\u2009=\u2009.02).\n                    <jats:italic>\n                      <jats:bold>Conclusions<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    More MVPA and less total sitting time, but not other accelerometer measures, were associated with lower osteoporotic fracture risk.\n                    <jats:italic>\n                      <jats:bold>Significance\/Implications<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    These data support interventions and physical activity guidelines aimed at promoting moderate- or vigorous-intensity movement and decreased sitting for osteoporotic fracture prevention.\n                  <\/jats:p>","DOI":"10.1123\/japa.2024-0233","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:07:25Z","timestamp":1770084445000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Accelerometer-Measured Physical Activity and Sedentary Behavior With Incident Clinical Osteoporotic Fractures Among Older Women: The Objective Physical Activity and Cardiovascular Health Study"],"prefix":"10.1123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5193-7042","authenticated-orcid":true,"given":"Steve","family":"Nguyen","sequence":"first","affiliation":[{"name":"Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9441-0198","authenticated-orcid":true,"given":"Carolyn J.","family":"Crandall","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California,\u00a0Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7167-3048","authenticated-orcid":true,"given":"John","family":"Bellettiere","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-5242","authenticated-orcid":true,"given":"Michael J.","family":"LaMonte","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo\u2014SUNY, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9532-976X","authenticated-orcid":true,"given":"Andrea Z.","family":"LaCroix","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"100","reference":[{"key":"r1","series-title":"2018 physical activity guidelines advisory committee scientific report","year":"2018","unstructured":"2018 Physical Activity Guidelines Advisory Committee. 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