{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:48:53Z","timestamp":1773773333251,"version":"3.50.1"},"reference-count":104,"publisher":"Human Kinetics","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"\n \n Introduction<\/jats:bold>\n :\n <\/jats:italic>\n The aging global population demands strategies to mitigate inflammation and anabolic resistance impacting older adults\u2019 quality of life. This randomized controlled trial examined the effects of multicomponent training on obese older women to enhance muscle health and functionality.\n \n Objectives<\/jats:bold>\n :\n <\/jats:italic>\n To assess the effects of a 12-week multicomponent training program on physical and functional capacities, body composition, metabolic health, and whole body muscle quality.\n \n Methods<\/jats:bold>\n :\n <\/jats:italic>\n Twenty-six older women (body mass index: >30\u00a0kg\/m\n 2<\/jats:sup>\n ) were randomized into an exercise (\n n<\/jats:italic>\n \u2009=\u200913) or control group (\n n<\/jats:italic>\n \u2009=\u200913). Exercise group participated in 12\u00a0weeks of supervised multicomponent training. Outcomes assessed pre- and postintervention including functional and physical capacities, body composition, waist circumference, lower limb muscle ultrasound, lipid profile, blood glucose, glucose tolerance, inflammatory cytokines, and type III procollagen peptide protein. Assessments were conducted blind to group allocation. Data were analyzed using R software.\n \n Results<\/jats:bold>\n :\n <\/jats:italic>\n Exercise group showed significant reductions in body fat percentage (Hedges\u2019\n g<\/jats:italic>\n : \u22120.14) and enhanced functional performance (sit-to-stand test: Hedges\u2019\n g<\/jats:italic>\n : 1.21). Improvements in cardiometabolic health and inflammatory profiles were observed, reducing morbidity risk. Correlations between inflammatory markers, body composition, and functional outcomes suggested a nonlinear cytokine response.\n \n Conclusion<\/jats:bold>\n :\n <\/jats:italic>\n Multicomponent training effectively improved body composition and functional capacity in obese older women, with potential benefits for inflammatory and metabolic health.\n \n Significance<\/jats:bold>\n :\n <\/jats:italic>\n These results underscore the importance of integrating exercise with dietary strategies to optimize outcomes.\n \n Trial Registration<\/jats:bold>\n :\n <\/jats:italic>\n ClinicalTrials.gov NCT05552677.\n \n Funding<\/jats:bold>\n :\n <\/jats:italic>\n Supported by FAPESP\/2022\/15078-4 and CnPq 303766\/2022-0.\n <\/jats:p>","DOI":"10.1123\/japa.2024-0341","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:07:03Z","timestamp":1756206423000},"page":"183-195","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Multicomponent Training on Metabolic and Functional Health of Older Women With Obesity: A Randomized Clinical Trial"],"prefix":"10.1123","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3068-2041","authenticated-orcid":true,"given":"Sofia Germano","family":"Travieso","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2013FMRP\/USP, Ribeir\u00e3o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-2692","authenticated-orcid":true,"given":"Gabriela Ueta","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2013FMRP\/USP, Ribeir\u00e3o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6301-3808","authenticated-orcid":true,"given":"Gabriela Ferreira","family":"Abud","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2013FMRP\/USP, Ribeir\u00e3o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-7431","authenticated-orcid":true,"given":"Marina Mello","family":"Villalba","sequence":"additional","affiliation":[{"name":"Biomechanics and Motor Control Laboratory, School of Physical Education and Sport of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4894-2550","authenticated-orcid":true,"given":"Gizela Pedroso","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2013FMRP\/USP, Ribeir\u00e3o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-5699","authenticated-orcid":true,"given":"Matheus Machado","family":"Gomes","sequence":"additional","affiliation":[{"name":"Biomechanics and Motor Control Laboratory, School of Physical Education and Sport of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-9149","authenticated-orcid":true,"given":"Julio Sergio","family":"Marchini","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2013FMRP\/USP, Ribeir\u00e3o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7343-2002","authenticated-orcid":true,"given":"Ellen Cristini","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2013FMRP\/USP, Ribeir\u00e3o Preto, Brazil"},{"name":"Laboratory of Exercise Physiology and Metabolism, School of Physical Education and Sports of Ribeir\u00e3o Preto, University of S\u00e3o Paulo\u2013EEFERP\/USP, Ribeir\u00e3o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"issue":"1","key":"r1","series-title":"Research, Society and Development,","doi-asserted-by":"publisher","DOI":"10.33448\/rsd-v11i1.25036","article-title":"A influ\u00eancia da atividade f\u00edsica para pessoas com obesidade: Uma revis\u00e3o integrativa","volume":"11","author":"Alves, J.A.","year":"2022","unstructured":"Alves, J.A., Andrade, K.A., & Pach\u00fa, C.O. 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