{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:37:26Z","timestamp":1772015846857,"version":"3.50.1"},"reference-count":37,"publisher":"Human Kinetics","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold>: The aim of the study was to provide an isotemporal substitution model to predict how changes in physical behavior may affect the cardiovascular parameters (CVPs) of older adults. <jats:bold>Methods<\/jats:bold>: Participants wore a thigh-mounted accelerometer for 7 days. Phenotype of the carotid, brachial, and popliteal artery was conducted using ultrasound. Isotemporal substitution was used to simulate the degree to which replacing 1 hour of physical behavior with another would affect CVP. <jats:bold>Results<\/jats:bold>: Substitution of sedentary behavior with Standing and sporadic moderate- to vigorous-intensity physical activity (MVPA accumulated in bouts &lt;10\u00a0min) would reduce resting heart rate [\u22126.20\u00a0beats per minute (\u221212.1 to \u22120.22) and \u22123.72\u00a0beats per minute (\u22127.01 to \u22120.44), respectively]. Substitution of sedentary behavior with light-intensity physical activity would reduce carotid artery diameter [\u22120.54\u00a0mm (\u22121.00 to \u22120.07)]. Substitution of Standing with sporadic MVPA would increase popliteal artery diameter [1.31\u00a0mm (0.11 to 2.51)]. <jats:bold>Conclusions<\/jats:bold>: Our modeling suggests that an accumulation of MVPA bouts that are shorter than the recommended 10-minute minimum may still improve CVP, with lower intensity physical activity also influencing CVP. Our findings are a promising avenue for lifestyle interventions in older adults to reduce the aging effects on CVP for those who cannot engage or sustain sufficient MVPA.<\/jats:p>","DOI":"10.1123\/jpah.2017-0326","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T06:39:32Z","timestamp":1522132772000},"page":"537-542","source":"Crossref","is-referenced-by-count":12,"title":["Segregating the Distinct Effects of Sedentary Behavior and Physical Activity on Older Adults\u2019 Cardiovascular Profile: Part 2\u2014Isotemporal Substitution Approach"],"prefix":"10.1123","volume":"15","author":[{"given":"Declan J.","family":"Ryan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorgen A.","family":"Wullems","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina K.","family":"Stebbings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher I.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire E.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys L.","family":"Onambele-Pearson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"key":"ref201","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1197\/j.aem.2007.06.040","article-title":"Use of ultrasound measurement of the inferior vena cava diameter as an objective tool in the assessment of children with clinical dehydration","volume":"14","author":"Chen","year":"2007","journal-title":"Acad Emerg Med"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0021-9150(00)00536-0","article-title":"Endothelial function of the popliteal artery in patients with coronary artery disease","volume":"155","author":"Angerer","year":"2001","journal-title":"Atherosclerosis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1113\/jphysiol.2003.045591","article-title":"Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity","volume":"551","author":"Bey","year":"2003","journal-title":"J Physiol"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1046\/j.1365-2362.2001.00884.x","article-title":"Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent history of impaired glucose tolerance","volume":"31","author":"Van Dijk","year":"2001","journal-title":"Eur J Clin Invest"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3109\/13813455.2015.1087033","article-title":"Functional and structural vascular adaptations following 8 weeks of low volume high intensity interval training in lower leg of type 2 diabetes patients and individuals at high risk of metabolic syndrome","volume":"121","author":"Madsen","year":"2015","journal-title":"Arch Physiol Biochem"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1365-2362.1997.1340681.x","article-title":"Effects of aerobic exercise training and yoga on the baroreflex in healthy elderly persons","volume":"27","author":"Bowman","year":"1997","journal-title":"Eur J Clin Invest"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1161\/HYPERTENSIONAHA.110.156331","article-title":"Longer time spent in light physical activity is associated with reduced arterial stiffness in older adults","volume":"56","author":"Gando","year":"2010","journal-title":"Hypertension"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1161\/01.CIR.90.4.1679","article-title":"Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. 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