{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:01:58Z","timestamp":1769083318108,"version":"3.49.0"},"reference-count":82,"publisher":"Human Kinetics","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>\n                    <jats:italic>\n                      <jats:bold>Background<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    To investigate the mediating effect of 24-hour movement behaviors on the relationship between chronic kidney disease (CKD) and mortality risk; additionally, to assess the health benefits of reallocating sedentary behavior (SB) with physical activity.\n                    <jats:italic>\n                      <jats:bold>Methods<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    This prospective cohort study included 88,795 participants (aged 43\u201378) from the UK Biobank with valid accelerometer data. A compositional mediation model assessed whether 24-hour movement behaviors mediate the CKD\u2013mortality association. A flexible parametric hazards model was used to estimate life expectancy under various reallocation scenarios of 24-hour movement behaviors.\n                    <jats:italic>\n                      <jats:bold>Results<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    During a median follow-up of 8.10\u00a0years, 3673 participants met CKD criteria, and 3117 died. CKD increased all-cause mortality risk through greater SB and reduced light-intensity physical activity and moderate to vigorous physical activity (MVPA; hazard ratios\u2009=\u20091.040; 95% confidence interval, 1.030\u20131.050). Reallocating 20\u00a0minutes per day of SB to MVPA increased life expectancy by 1.70\u00a0years at age 45 (95% confidence interval, 0.51\u20134.34).\n                    <jats:italic>\n                      <jats:bold>Conclusions<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    Twenty four-hour movement behaviors partially mediate mortality risk in CKD, with MVPA showing the strongest protective effect. Interventions that reduce SB and increase MVPA can improve survival in CKD populations.\n                  <\/jats:p>","DOI":"10.1123\/jpah.2025-0467","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:36:19Z","timestamp":1760783779000},"page":"229-236","source":"Crossref","is-referenced-by-count":0,"title":["The Mediating Effect of 24-Hour Movement Behaviors on Mortality Risk in Chronic Kidney Disease: A Compositional Mediation and Life Expectancy Analysis"],"prefix":"10.1123","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0140-521X","authenticated-orcid":true,"given":"Zhehao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne R.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiade","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutai","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoman","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China"},{"name":"Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, Jinan University, Ministry of Education, Guangzhou, GD, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1990-6788","authenticated-orcid":true,"given":"Ziqiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"issue":"10225","key":"r1","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the global burden of disease study 2017","volume":"395","author":"Bikbov B","year":"2020","unstructured":"Bikbov B, Purcell CA, Levey AS, et\u00a0al. 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