{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:36:37Z","timestamp":1793115397642,"version":"4.5.0"},"reference-count":47,"publisher":"Human Kinetics","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>\n                    <jats:italic>\n                      <jats:bold>Background<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    Physical activity (PA) may help to delay or possibly prevent cognitive decline and dementia. However, few studies have adopted a life-course approach to prospectively examine repeated measures of PA in relation to cognitive decline.\n                    <jats:italic>\n                      <jats:bold>Methods<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    Framingham Heart Study Offspring and Omni 1 participants without prevalent dementia who had \u22653 self-reported PA measures and \u22652 cognitive domain factor score measures were included (n\u2009=\u20092229). Memory, executive function, and language factor scores were previously derived using bifactor confirmatory factor analysis models. Group-based multitrajectory models characterized PA patterns over the adult life-course (ages 17\u201396\u00a0y). Linear mixed-effects models estimated annual changes in cognitive domain factor scores across PA trajectory groups over the same time period.\n                    <jats:italic>\n                      <jats:bold>Results<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    We identified 4 PA trajectories: (1) stabilizers: decline from early adulthood through midlife and then stable after age 50 (n\u2009=\u2009176), (2) decliners: constant decline over adulthood (n\u2009=\u2009526), (3) reversers: increase from early adulthood through midlife and then decline after age 70 (n\u2009=\u20091145), and (4) plummeters: slow decline from early adulthood through midlife and then sharp decline after age 75 (n\u2009=\u2009382; reference). Compared with the reference group, stabilizers had 0.012 SD\/year (95% CI, 0.004\u20130.02) slower memory decline, 0.012 SD\/year (95% CI, 0.005\u20130.02) slower executive function decline, and 0.015 SD\/year (95% CI, 0.007\u20130.02) slower language decline. Decliners had slower cognitive decline across all domains, and reversers had slower language decline.\n                    <jats:italic>\n                      <jats:bold>Conclusions<\/jats:bold>\n                      :\n                    <\/jats:italic>\n                    Our findings suggest that sustaining PA in mid-to-late life and preventing later life declines may help mitigate cognitive decline with aging.\n                  <\/jats:p>","DOI":"10.1123\/jpah.2026-0133","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:04:17Z","timestamp":1785931457000},"page":"1652-1660","source":"Crossref","is-referenced-by-count":0,"title":["How Life-Course Trajectories of Physical Activity Track With Cognitive Decline"],"prefix":"10.1123","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9641-052X","authenticated-orcid":true,"given":"Francesca R.","family":"Marino","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6495-3087","authenticated-orcid":true,"given":"Huitong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"},{"name":"The Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3043-3942","authenticated-orcid":true,"given":"Honghuang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-4491","authenticated-orcid":true,"given":"Rhoda","family":"Au","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"},{"name":"The Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"},{"name":"Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA"},{"name":"Slone Epidemiology Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"},{"name":"Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-6808","authenticated-orcid":true,"given":"Phillip H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"},{"name":"The Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"},{"name":"Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"100","reference":[{"issue":"10452","key":"r1","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the lancet standing commission","volume":"404","author":"Livingston G","year":"2024","unstructured":"Livingston G, Huntley J, Liu KY, et\u00a0al. 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