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Participants were randomly assigned to Tai Chi (<jats:italic>n<\/jats:italic>\u2009=\u2009120) or general aerobic exercise (<jats:italic>n<\/jats:italic>\u2009=\u2009120) for 3 months. Depressive symptoms and serum lipid levels were measured at baseline and postintervention. A generalized estimating equation was used to assess group differences over time. The Tai Chi group exhibited significantly greater reductions in depressive symptoms and improvements in serum lipid profiles compared with the general aerobic exercise group. Tai Chi\u2019s mind\u2013body synergy may enhance its antidepressant effects, offering a promising approach to mental health and healthy aging.<\/jats:p>","DOI":"10.1123\/jsep.2024-0269","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:20:19Z","timestamp":1741890019000},"page":"167-175","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Tai Chi Versus General Aerobic Exercise on Depressive Symptoms and Serum Lipid Levels Among Older Persons With Depressive Symptoms: A Randomized Controlled Study"],"prefix":"10.1123","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7877-8790","authenticated-orcid":true,"given":"Chuanya","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, SC, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, SC, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9721-1194","authenticated-orcid":true,"given":"Liangying","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, SC, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, SC, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4889-2429","authenticated-orcid":true,"given":"Biru","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, SC, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, SC, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0301-3689","authenticated-orcid":true,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Ya\u2019an Polytechnic College, Ya\u2019an, SC, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6444-6357","authenticated-orcid":true,"given":"Jingyuan","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, SC, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, SC, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-0307","authenticated-orcid":true,"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, SC, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, SC, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0207-8580","authenticated-orcid":true,"given":"Weijun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Chengdu Zhiyong Technology Company Limited, Chengdu, SC, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5409-2893","authenticated-orcid":true,"given":"Shujuan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, SC, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, SC, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"100","reference":[{"issue":"2","key":"r1","series-title":"Biological Psychiatry,","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.biopsych.2010.04.011","article-title":"Gender and genotype modulation of the association between lipid levels and depressive symptomatology in community-dwelling elderly (The ESPRIT Study)","volume":"68","author":"Ancelin, M.L.","year":"2010","unstructured":"Ancelin, M.L., Carriere, I., Boulenger, J.P., Malafosse, A., Stewart, R., Cristol, J.P., Ritchie, K., Chaudieu, I., & Dupuy, A.M. 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