{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:28:34Z","timestamp":1761766114977},"reference-count":0,"publisher":"Human Kinetics","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:sec sec-type=\"objective\"><jats:title>Objective:<\/jats:title><jats:p>This commentary discusses known links between Exertional Heat Illness (EHI), Malignant Hyperthermia (MH), and other hereditary diseases of muscle. Genetic and functional testing is also evaluated as measures of fitness to return to duty\/play.<\/jats:p><\/jats:sec><jats:sec sec-type=\"data sources\"><jats:title>Data Sources:<\/jats:title><jats:p>Reviews and research articles from Sports Medicine, Applied Physiology, and Anesthesiology.<\/jats:p><\/jats:sec><jats:sec sec-type=\"data extraction\"><jats:title>Data Extraction:<\/jats:title><jats:p>Detailed comparisons of existing literature regarding clinical cases of EHI and MH and the potential utility of genetic testing, specifically the ryanodine receptor (RYR1) gene and other genes related to disorders of skeletal muscle.<\/jats:p><\/jats:sec><jats:sec sec-type=\"data synthesis\"><jats:title>Data Synthesis:<\/jats:title><jats:p>EHI is a complex disorder wherein physiological, environmental, and hereditary factors interact to endanger an individual\u2019s ability to maintain thermal homeostasis.<\/jats:p><\/jats:sec><jats:sec sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>Individuals\u2019 genetic background is likely to play an important role, particularly when EHI recurs. Recurrent EHI has been associated with MH and other genetic disorders, highlighting the importance of identification and exclusion of individuals with known high risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1123\/jsr.16.3.222","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T12:27:14Z","timestamp":1470832034000},"page":"222-226","source":"Crossref","is-referenced-by-count":6,"title":["Identification of Risk Factors for Exertional Heat Illness: A Brief Commentary on Genetic Testing"],"prefix":"10.1123","volume":"16","author":[{"given":"Sheila","family":"Muldoon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Bunger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Deuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nyamkhishig","family":"Sambuughin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","container-title":["Journal of Sport Rehabilitation"],"original-title":[],"link":[{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/jsr\/16\/3\/article-p222.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.humankinetics.com\/downloadpdf\/journals\/jsr\/16\/3\/article-p222.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T23:18:09Z","timestamp":1653002289000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.humankinetics.com\/view\/journals\/jsr\/16\/3\/article-p222.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1123\/jsr.16.3.222","relation":{},"ISSN":["1056-6716","1543-3072"],"issn-type":[{"value":"1056-6716","type":"print"},{"value":"1543-3072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}