{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T15:48:23Z","timestamp":1771688903904,"version":"3.50.1"},"reference-count":10,"publisher":"Human Kinetics","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"Clinical Scenario<\/jats:bold>:<\/jats:italic> Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper-extremity. Due to the involvement of the median nerve, long-term compression of this nerve can lead to hand dysfunction and disability that can impact work and daily life. As such, early treatment is warranted to prevent any long-term damage to the median nerve. Conservative management is utilized in those with mild to moderate CTS. Neural mobilizations can aid in the reduction of neural edema, neural mobility, and neural adhesion while improving nerve conduction. Clinical Question<\/jats:bold>:<\/jats:italic> Is neurodynamics effective in reducing pain and reported symptoms in those with CTS? Summary of Key Findings<\/jats:bold>:<\/jats:italic> Four studies were included, with 2 studies utilizing passive neural mobilizations, one study using active techniques, and one study using active neural mobilizations with splinting. All studies showed large effect size for pain, symptom severity, and physical function. Clinical Bottom Line<\/jats:bold>:<\/jats:italic> Neurodynamics is an effective treatment for CTS. Splinting is only effective when combined with neurodynamics. Strength of Recommendation<\/jats:bold>:<\/jats:italic> Level B evidence to support the use of neurodynamics for the treatment of CTS.<\/jats:p>","DOI":"10.1123\/jsr.2021-0155","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T10:47:19Z","timestamp":1640861239000},"page":"501-504","source":"Crossref","is-referenced-by-count":7,"title":["Neurodynamics Is an Effective Intervention for Carpal Tunnel Syndrome"],"prefix":"10.1123","volume":"31","author":[{"given":"Stephanie","family":"Wise","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Bettleyon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"key":"r1","series-title":"Open Orthop J","first-page":"69","article-title":"Carpal tunnel syndrome: a review of the recent literature","volume":"6","author":"Ibrahim I","year":"2012","unstructured":"Ibrahim I, Khan WS, Goddard N, Smitham P. Carpal tunnel syndrome: a review of the recent literature. Open Orthop J. 2012;6:69\u201376. PubMed ID: 22470412 doi:10.2174\/187432500120601006922470412"},{"issue":"4","key":"r2","series-title":"J Manipulative Physiol Ther","first-page":"263","article-title":"Efficacy of manual therapy including neurodynamic techniques for the treatment of carpal tunnel syndrome: a randomized controlled trial","volume":"40","author":"Wolny T","year":"2017","unstructured":"Wolny T, Saulicz E, Linek P, Shacklock M, My\u015bliwiec A. Efficacy of manual therapy including neurodynamic techniques for the treatment of carpal tunnel syndrome: a randomized controlled trial. J Manipulative Physiol Ther. 2017;40(4):263\u2013272. PubMed ID: 28395984 doi:10.1016\/j.jmpt.2017.02.00428395984"},{"issue":"5","key":"r3","series-title":"Arch Phys Med Rehabil","first-page":"843","article-title":"Neurodynamic techniques versus \u201csham\u201d therapy in the treatment of carpal tunnel syndrome: a randomized placebo-controlled trial","volume":"99","author":"Wolny T","year":"2018","unstructured":"Wolny T, Linek P. Neurodynamic techniques versus \u201csham\u201d therapy in the treatment of carpal tunnel syndrome: a randomized placebo-controlled trial. Arch Phys Med Rehabil. 2018;99(5):843\u2013854. PubMed ID: 29307812 doi:10.1016\/j.apmr.2017.12.00529307812"},{"issue":"2","key":"r4","series-title":"Int J Health Allied Sci","first-page":"104","article-title":"Motor nerve conduction velocity and function in carpal tunnel syndrome following neural mobilization: A randomized clinical trial","volume":"5","author":"Goyal M","year":"2016","unstructured":"Goyal M, Mehta SK, Rana N, et\u00a0al. Motor nerve conduction velocity and function in carpal tunnel syndrome following neural mobilization: A randomized clinical trial. Int J Health Allied Sci. 2016;5(2):104. doi:10.4103\/2278-344X.180434"},{"issue":"1","key":"r5","series-title":"J Manipulative Physiol Ther","first-page":"50","article-title":"Effectiveness of nerve gliding exercises on carpal tunnel syndrome: a systematic review","volume":"40","author":"Ballestero-P\u00e9rez R","year":"2017","unstructured":"Ballestero-P\u00e9rez R, Plaza-Manzano G, Urraca-Gesto A, et\u00a0al. Effectiveness of nerve gliding exercises on carpal tunnel syndrome: a systematic review. J Manipulative Physiol Ther. 2017;40(1):50\u201359. PubMed ID: 27842937 doi:10.1016\/j.jmpt.2016.10.00427842937"},{"key":"r6","series-title":"Clinical Neurodynamics: A System of Musculoskeletal Treatment","author":"Shacklock M","year":"2005","unstructured":"Shacklock M. Clinical Neurodynamics: A System of Musculoskeletal Treatment. Philadelphia, PA: Elselvier; 2005."},{"key":"r7","series-title":"Man Ther","first-page":"213","article-title":"Do \u201csliders\u201d slide and \u201ctensioners\u201d tension? An analysis of neurodynamic techniques and considerations regarding their application","volume":"13","author":"Coppieters MW","year":"2008","unstructured":"Coppieters MW, Butler DS. Do \u201csliders\u201d slide and \u201ctensioners\u201d tension? An analysis of neurodynamic techniques and considerations regarding their application. Man Ther. 2008;13:213\u2013221. PubMed ID: 1739814017398140"},{"issue":"3","key":"r8","series-title":"Clin Rehabil","first-page":"408","article-title":"Is manual therapy based on neurodynamic techniques effective in the treatment of carpal tunnel syndrome? A randomized controlled trial","volume":"33","author":"Wolny T","year":"2019","unstructured":"Wolny T, Linek P. Is manual therapy based on neurodynamic techniques effective in the treatment of carpal tunnel syndrome? A randomized controlled trial. Clin Rehabil. 2019;33(3):408\u2013417. PubMed ID: 30306805 doi:10.1177\/026921551880521330306805"},{"key":"r9","series-title":"Oxford Centre for Evidence-Based Medicine","article-title":"The Oxford Levels of Evidence 2","unstructured":"OCEBM Levels of Evidence Working Group. The Oxford Levels of Evidence 2. Oxford Centre for Evidence-Based Medicine. https:\/\/www.cebm.ox.ac.uk\/resources\/levels-of-evidence\/ocebm-levels-of-evidence"},{"issue":"1","key":"r10","series-title":"J Man Manip Ther","first-page":"8","article-title":"Neural mobilization: a systematic review of randomized controlled trials with an analysis of therapeutic efficacy","volume":"16","author":"Ellis RF","year":"2008","unstructured":"Ellis RF, Hing WA. Neural mobilization: a systematic review of randomized controlled trials with an analysis of therapeutic efficacy. J Man Manip Ther. 2008;16(1):8\u201322. 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