{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:37:22Z","timestamp":1784907442706,"version":"3.55.0"},"reference-count":51,"publisher":"Human Kinetics","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:p><jats:italic><jats:bold>Context<\/jats:bold>:<\/jats:italic> Many individuals who sustain a lateral ankle sprain (LAS) fail to return to prior activity due to residual symptoms; and report elevated levels of injury-related fear, decreased function, and decreased health-related quality of life (HRQOL). Additionally, individuals with history of LAS exhibit deficits in neurocognitive functional measures like visuomotor reaction time (VMRT), which contributes to worse patient-reported outcome scores. The aim of this study was to examine the relationship between HRQOL and lower-extremity (LE) VMRT in individuals with LAS history. <jats:italic><jats:bold>Design<\/jats:bold>:<\/jats:italic> Cross-sectional. <jats:italic><jats:bold>Methods<\/jats:bold>:<\/jats:italic> Young adult female volunteers with history of LAS (n\u2009=\u200922; age\u2009=\u200924 [3.5]\u00a0y; height\u2009=\u2009163.1 [9.8]\u00a0cm; mass\u2009=\u200965.1 [11.5]\u00a0kg; and time since last LAS\u2009=\u200967.8 [50.5]\u00a0mo) completed HRQOL outcomes including the following: (1)\u00a0Tampa Scale of Kinesiophobia-11, (2)\u00a0Fear-Avoidance Beliefs Questionnaire, (3)\u00a0Penn State Worry Questionnaire, (4)\u00a0modified Disablement in the Physically Active Scale, and (5)\u00a0Foot and Ankle Disability Index (FADI). Additionally, participants completed a LE-VMRT task by responding to a visual stimulus using their foot to deactivate light sensors. Participants completed trials bilaterally. Separate Spearman rho correlations were performed to assess the relationship between patient-reported outcomes assessing constructs of HRQOL and LE-VRMT bilaterally. Significance was set at <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05. <jats:italic><jats:bold>Results<\/jats:bold>:<\/jats:italic> There was a strong, significant negative correlation between FADI-Activities of Daily Living (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u2212.68; <jats:italic>P<\/jats:italic>\u2009=\u2009.002) and FADI-Sport (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u2212.76; <jats:italic>P<\/jats:italic>\u2009=\u2009.001) scores and injured limb LE-VMRT; moderate, significant negative correlations between the uninjured limb LE-VMRT and FADI-Activities of Daily Living (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u2212.60; <jats:italic>P<\/jats:italic>\u2009=\u2009.01) and FADI-Sport (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u2212.60; <jats:italic>P<\/jats:italic>\u2009=\u2009.01) scores; and moderate, significant positive correlations between the injured limb LE-VMRT and modified Disablement in the Physically Active Scale-Physical Summary Component (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009.52; <jats:italic>P<\/jats:italic>\u2009=\u2009.01) and modified Disablement in the Physically Active Scale-Total (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009.54; <jats:italic>P<\/jats:italic>\u2009=\u2009.02) scores. All other correlations were not statistically significant. <jats:italic><jats:bold>Conclusions<\/jats:bold>:<\/jats:italic> Young adult women with history of LAS demonstrated an association between self-reported constructs of HRQOL and LE-VMRT. As LE-VMRT is a modifiable injury risk factor, future studies should examine the effectiveness of interventions designed to improve LE-VMRT and the impact on self-reported HRQOL.<\/jats:p>","DOI":"10.1123\/jsr.2022-0199","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T03:45:08Z","timestamp":1677469508000},"page":"433-439","source":"Crossref","is-referenced-by-count":5,"title":["The Relationship Between Health-Related Quality of Life and Lower-Extremity Visuomotor Reaction Time in Young Adult Women Following Ankle Sprain"],"prefix":"10.1123","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-6378","authenticated-orcid":true,"given":"Katherine A.","family":"Bain","sequence":"first","affiliation":[{"name":"Division of Physical Therapy, Shenandoah University, Leesburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-896X","authenticated-orcid":true,"given":"Shelby","family":"Baez","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-7377","authenticated-orcid":true,"given":"Kyle B.","family":"Kosik","sequence":"additional","affiliation":[{"name":"University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-1804","authenticated-orcid":true,"given":"Matthew C.","family":"Hoch","sequence":"additional","affiliation":[{"name":"University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-9354","authenticated-orcid":true,"given":"Johanna M.","family":"Hoch","sequence":"additional","affiliation":[{"name":"University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan F.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-8580","authenticated-orcid":true,"given":"Richard D.","family":"Andreatta","sequence":"additional","affiliation":[{"name":"University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-5587","authenticated-orcid":true,"given":"Phillip A.","family":"Gribble","sequence":"additional","affiliation":[{"name":"University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"100","reference":[{"issue":"4","key":"r1","series-title":"Am J Med","first-page":"324","article-title":"What is the clinical course of acute ankle sprains? 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