{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T20:14:40Z","timestamp":1776111280759,"version":"3.50.1"},"reference-count":10,"publisher":"Human Kinetics","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p><jats:italic><jats:bold>Clinical Scenario<\/jats:bold>:<\/jats:italic> Ankle sprains are one of the most common injuries in athletics, and many lead to recurrent sprains, chronic ankle instability, and persistent symptoms. Treatment improvements are needed. Platelet-rich plasma (PRP) involves formulating autologous plasma with higher platelet concentration to be injected in the desired tissue. There is currently high-quality evidence supporting the use of PRP with lateral epicondylitis and knee osteoarthritis to accelerate the healing process and decrease pain. <jats:italic><jats:bold>Clinical Question<\/jats:bold>:<\/jats:italic> Does the injection of PRP relieve pain faster and improve function compared with no injection or placebo in patients with a lateral ankle sprain? <jats:italic><jats:bold>Summary of Key Findings<\/jats:bold>:<\/jats:italic> A computerized search yielded 191 studies; of these, 3 studies fit the inclusion and exclusion criteria. PRP injection reduces pain and increases function after lateral ankle sprain 5 to 8\u00a0weeks after intervention. <jats:italic><jats:bold>Clinical Bottom Line<\/jats:bold>:<\/jats:italic> The use of PRP after lateral ankle sprain to decrease pain and increase function is supported with moderate evidence. <jats:italic><jats:bold>Strength of Recommendation<\/jats:bold>:<\/jats:italic> Based on the Strength of Recommendation Taxonomy, evidence from the included studies is considered as level B, reflecting limited quality patient-oriented evidence.<\/jats:p>","DOI":"10.1123\/jsr.2023-0425","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T18:34:34Z","timestamp":1720809274000},"page":"558-561","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Platelet-Rich Plasma in Reducing Pain and Increasing Function After Acute Lateral Ankle Sprain: A Critically Appraised Topic"],"prefix":"10.1123","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0522-0477","authenticated-orcid":true,"given":"Erin","family":"Frey","sequence":"first","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1405-0001","authenticated-orcid":true,"given":"Christopher D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9090-1851","authenticated-orcid":true,"given":"Brady","family":"Tripp","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"key":"r1","series-title":"StatPearls","article-title":"Acute ankle sprain","author":"Melanson SW","year":"2023","unstructured":"Melanson SW, Shuman VL. 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