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This study aimed to provide a comprehensive assessment of the relationship of moderate to vigorous physical activity (MVPA) with both angiogenic factors and EPC function in healthy children. <jats:italic><jats:bold>Methods<\/jats:bold>:<\/jats:italic> Forty children (22 boys and 18 girls) aged 7 to 11 years participated in a 10-week MVPA program (duration: 45\u00a0min; intensity: 75%\u201385% of heart rate reserve; frequency: 4\u00a0sessions\/wk). The anthropometric data, biochemical profile, EPCs number, EPCs colony-forming units, and vascular endothelial growth factor-A (VEGF-A) and nitric oxide (NO) plasma levels were evaluated before and after the MVPA program. <jats:italic><jats:bold>Results<\/jats:bold>:<\/jats:italic> After a 10-week MVPA program, a significant increase was detected in circulating\/functional capacity of EPCs, NO, and VEGF-A levels, associated with improvement of waist circumference and estimated maximum rate of oxygen consumption (VO<jats:sub>2<\/jats:sub>max). A strong positive correlation was found between delta of EPCs number and variation of both NO level (<jats:italic>r<\/jats:italic>\u2009=\u2009.677, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and VEGF-A level (<jats:italic>r<\/jats:italic>\u2009=\u2009.588, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Furthermore, a significant correlation between NO level variation and delta of VEGF-A level was observed (<jats:italic>r<\/jats:italic>\u2009=\u2009.708, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). <jats:italic><jats:bold>Conclusion<\/jats:bold>:<\/jats:italic> Our findings suggest that lifestyle intervention implemented by MVPA program can contribute meaningfully to improve circulating\/functional capacity of EPCs in healthy children, possibly due to the increase of plasma NO and VEGF-A levels.<\/jats:p>","DOI":"10.1123\/pes.2018-0178","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T23:24:21Z","timestamp":1547594661000},"page":"322-329","source":"Crossref","is-referenced-by-count":8,"title":["Beneficial Impact of Moderate to Vigorous Physical Activity Program on Circulating Number and Functional Capacity of Endothelial Progenitor Cells in Children: The Crucial Role of Nitric Oxide and VEGF-A"],"prefix":"10.1123","volume":"31","author":[{"given":"Livia Victorino","family":"Souza","sequence":"first","affiliation":[{"name":"Federal University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franciele","family":"De Meneck","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa Mieko","family":"Higa","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana Hiromi","family":"Akamine","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo","family":"Franco","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"key":"r1","series-title":"Atherosclerosis","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0021-9150(01)00566-4","article-title":"Correlation of habitual physical activity levels with flow-mediated dilation of the brachial artery in 5\u201310 year old children","volume":"160","author":"Abbott RA","year":"2002","unstructured":"Abbott RA, Harkness MA, Davies PS. 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