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Children\u2019s guided activity play (GAP)-based PA programs have emerged as effective strategies to improve cardiovascular risk factors and health-related fitness. This study proposes to investigate whether GAP improves children\u2019s cutaneous microvascular reactivity and health-related fitness. <jats:italic><jats:bold>Methods<\/jats:bold>:<\/jats:italic> Children\u2019s (n\u2009=\u200918; 9.8\u2009[1.5]\u00a0y) PA during a 5-week (4\u00a0d\/wk; 1\u00a0h\/d) GAP program was assessed (accelerometry) with preassessments and postassessments for anthropometric, musculoskeletal fitness, blood pressure, estimated aerobic power, and cutaneous microvascular reactivity. <jats:italic><jats:bold>Results<\/jats:bold>:<\/jats:italic> PA averaged 556\u2009(132)\u00a0kcal\u00b7week<jats:sup>\u22121<\/jats:sup> at 34.7%\u2009(7.5%) time at moderate to vigorous intensity. Resting heart rate (\u22129.5%) and diastolic blood pressure (\u22127.8%) were reduced without changes in health-related fitness indices. Cutaneous microvascular reactivity to sodium nitroprusside iontophoresis increased the average perfusion (+36.8%), average cutaneous vascular conductance (+30%), the area under the curve (+28.8%), and a faster rise phase (+40%) of perfusion (quadratic modeling; <jats:italic>P<\/jats:italic>\u2009\u2264\u2009.05). Chi-square and crosstabulation analysis revealed significant association between children\u2019s PA levels and sodium nitroprusside average perfusion levels, where children with PA levels\u2009\u2265205.1\u00a0kcal<jats:sup>.<\/jats:sup>55\u00a0minute<jats:sup>\u22121<\/jats:sup> were overrepresented in the medium\/high levels of sodium nitroprusside perfusion. <jats:italic><jats:bold>Conclusion<\/jats:bold>:<\/jats:italic> A 5-week GAP modified the microvascular reactivity in children without changes in body mass, musculoskeletal fitness, or estimated aerobic power.<\/jats:p>","DOI":"10.1123\/pes.2023-0138","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T16:27:22Z","timestamp":1714408042000},"page":"128-137","source":"Crossref","is-referenced-by-count":0,"title":["A 5-Week Guided Active Play Program Modulates Skin Microvascular Reactivity in Healthy Children"],"prefix":"10.1123","volume":"37","author":[{"given":"Asal","family":"Moghaddaszadeh","sequence":"first","affiliation":[{"name":"Pediatric Exercise Physiology Laboratory, Faculty of Health, York University, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-6620","authenticated-orcid":true,"given":"Emilie","family":"Roudier","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, ON, Canada"},{"name":"Muscle Health Research Center, York University, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8865-1921","authenticated-orcid":true,"given":"Heather","family":"Edgell","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, ON, Canada"},{"name":"Muscle Health Research Center, York University, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-630X","authenticated-orcid":true,"given":"Agnes","family":"Vinet","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie Exp\u00e9rimentale Cardiovasculaire, Facult\u00e9 des Sciences, Avignon Universit\u00e9, Avignon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-1996","authenticated-orcid":true,"given":"Angelo N.","family":"Belcastro","sequence":"additional","affiliation":[{"name":"Pediatric Exercise Physiology Laboratory, Faculty of Health, York University, Toronto, ON, Canada"},{"name":"School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, ON, Canada"},{"name":"Muscle Health Research Center, York University, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"100","reference":[{"issue":"6","key":"r1","series-title":"Eur Heart J","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1093\/eurheartj\/ehm633","article-title":"Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure","volume":"29","author":"Aggoun Y","year":"2008","unstructured":"Aggoun Y, Farpour-Lambert NJ, Marchand LM, Golay E, Maggio ABR, Beghetti M. 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