{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:39:10Z","timestamp":1776094750258,"version":"3.50.1"},"reference-count":102,"publisher":"Human Kinetics","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p>Galectin-3 is a pro-inflammatory biomarker associated with the pathogenesis of heart failure (HF). Physical-activity reduces the risk of heart-failure by modification of inflammation and fibrosis. The purpose of this study was to compare the effects of 8 weeks of high-intensity interval training (HIIT) versus moderate-intensity aerobic continuous training on a predictive factor of HF in postmenopausal women. Thirty sedentary postmenopausal women were randomly assigned to three groups. The first group performed the HIIT program at 60%\u201390%, and the second group performed an exercise program at 50%\u201365% of HR reserve. The control group maintained their normal daily regular physical activity level. The gene expressions of galectin-3 and lipid profiles were measured at the baseline and the end of Week 8. The HIIT and moderate-intensity aerobic continuous training attenuated the gene expression of galectin-3, serum low-density lipoprotein, cholesterol, and triglyceride concentrations and enhanced high-density lipoprotein concentrations. These changes were considerably higher in the HIIT group. Our results show that HIIT is superior to moderate-intensity aerobic continuous training in improving the decrease in HF risk in postmenopausal women.<\/jats:p>","DOI":"10.1123\/japa.2019-0213","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T14:38:46Z","timestamp":1594996726000},"page":"987-995","source":"Crossref","is-referenced-by-count":10,"title":["Effect of High-Intensity Interval Training Versus Moderate-Intensity Aerobic Continuous Training on Galectin-3 Gene Expression in Postmenopausal Women: A Randomized Controlled Trial"],"prefix":"10.1123","volume":"28","author":[{"given":"Diana","family":"Keyhani","sequence":"first","affiliation":[]},{"given":"Bakhtyar","family":"Tartibian","sequence":"additional","affiliation":[]},{"given":"Arezou","family":"Dabiri","sequence":"additional","affiliation":[]},{"given":"Ana Maria 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Research,"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1152\/japplphysiol.00518.2014","article-title":"High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: A pilot study","volume":"119","author":"Angadi","year":"2014","journal-title":"Journal of Applied Physiology,"},{"key":"ref911","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/13697130601114917","article-title":"Menopause and cardiovascular disease: The evidence","volume":"10","author":"Rosano","year":"2007","journal-title":"Climacteric,"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2796.2011.02476.x","article-title":"The fibrosis marker galectin-3 and outcome in the general population","volume":"272","author":"de Boer","year":"2012","journal-title":"Journal of Internal Medicine,"},{"key":"ref261","first-page":"50","article-title":"Mineralocorticoid receptor antagonists modulate galectin-3 and interleukin-33\/ST2 signaling in left ventricular systolic dysfunction after acute myocardial infarction","volume":"3","author":"Lax","year":"2015","journal-title":"JACC: Heart Failure,"},{"key":"ref881","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/dom.12156","article-title":"The effect of physical activity on mediators of inflammation","volume":"15","author":"Nimmo","year":"2013","journal-title":"Diabetes, Obesity and Metabolism,"},{"key":"ref91","first-page":"853","article-title":"Association of physical activity or fitness with incident heart failure: A systematic review and meta-analysis","volume":"8","author":"Echouffo-Tcheugui","year":"2015","journal-title":"Circulation: Heart Failure,"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11897-010-0004-x","article-title":"Galectin-3 in cardiac remodeling and heart failure","volume":"7","author":"de Boer","year":"2010","journal-title":"Current Heart 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