{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:01:07Z","timestamp":1791090067720,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1124\/dmd.104.002303","type":"journal-article","created":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T01:58:23Z","timestamp":1098842303000},"page":"102-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["METABOLISM OF 26,26,26,27,27,27-F6-1\u03b1,23S,25-TRIHYDROXYVITAMIN D3 BY HUMAN UDP-GLUCURONOSYLTRANSFERASE 1A3*"],"prefix":"10.1016","volume":"33","author":[{"given":"Noriyuki","family":"Kasai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Sakaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raku","family":"Shinkyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Ikushiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Iyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyo","family":"Inouye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.104.002303_bib1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1053\/ajkd.1998.v32.pm9708607","article-title":"Controlled trail of falecalcitol versus alfacalcidol in suppression of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.","volume":"32","author":"Akiba","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1124\/dmd.104.002303_bib2","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/jbmr.5650090818","article-title":"Profile of ligand specificity of the vitamin D binding protein for 1\u03b1,25-dihydroxyvitamin D3 and its analogs.","volume":"9","author":"Bishop","year":"1994","journal-title":"J Bone Miner Res"},{"key":"10.1124\/dmd.104.002303_bib3","first-page":"200","article-title":"Structure-function relationships in the vitamin D endocrine system.","volume":"16","author":"Bouillon","year":"1995","journal-title":"Endocr Rev"},{"key":"10.1124\/dmd.104.002303_bib4","first-page":"52","article-title":"Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltrasnferases (UGTs) 1A1, 1A3 and 2B7.","volume":"45","author":"Cheng","year":"1998","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.104.002303_bib5","first-page":"507","article-title":"Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltraseferase 1A3.","volume":"26","author":"Green","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.104.002303_bib6","first-page":"860","article-title":"Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltrasferase proteins.","volume":"26","author":"Green","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.104.002303_bib7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/004982598239380","article-title":"Rat CYP24 catalyzes 23S-hydroxylation of 26,26,26,27,27,27-hexafluorocalcitriol in vitro.","volume":"28","author":"Hayashi","year":"1998","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.104.002303_bib8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0090-9556(24)15257-9","article-title":"Retigabine N-glucuronidation and its potential role in enterohepatic circulation.","volume":"27","author":"Hiller","year":"1999","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.104.002303_bib9","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/bj2950509","volume":"295","author":"Honda","year":"1993","journal-title":"Biochem J"},{"key":"10.1124\/dmd.104.002303_bib10","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0090-9556(24)15358-5","article-title":"In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model.","volume":"28","author":"Houston","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.104.002303_bib11","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/0006-2952(93)90207-D","article-title":"Effect of substituting fluorine for hydrogen at C-26 and C-27 on the side chain of 1,25-dihydroxyvitamin D3.","volume":"45","author":"Inaba","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.104.002303_bib12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s007740050027","article-title":"Efficacy and safety of long term oral falecalcitriol treatment in patients with renal osteodystrophy.","volume":"16","author":"Inoue","year":"1998","journal-title":"J Bone Miner Metab"},{"key":"10.1124\/dmd.104.002303_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10038-003-0119-y","article-title":"Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity.","volume":"49","author":"Iwai","year":"2004","journal-title":"J Hum Genet"},{"key":"10.1124\/dmd.104.002303_bib14","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1124\/dmd.32.8.870","article-title":"Sequential metabolism of 2,3,7-trichlorodibenzo-p-dioxin (2,3,7-triCDD) by cytochrome P450 and UDP-glucuronosyltransferase in human liver microsomes.","volume":"32","author":"Kasai","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.104.002303_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/endo-128-1-81","article-title":"Effects of a highly potent fluoro analog of 1\u03b1,25-dihydroxyvitamin D3 on human bone-deprived cells.","volume":"128","author":"Kiriyama","year":"1991","journal-title":"Endocrinology"},{"key":"10.1124\/dmd.104.002303_bib16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1124\/dmd.31.8.973","article-title":"Disposition and metabolism of F6-1\u03b1,25(OH)2 vitamin D3 and 1\u03b1,25(OH)2 vitamin D3 in the parathyroid glands of rats dosed with tritium-labeled compounds.","volume":"31","author":"Komuro","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.104.002303_bib17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/004982599238425","volume":"29","author":"Komuro","year":"1999","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.104.002303_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00008571-199708000-00001","article-title":"The UDP glucuronosyltransferase gene family: recommended nomenclature and update based on evolutionary divergence","volume":"7","author":"Mackenzie","year":"1997","journal-title":"Pharmacogenomics"},{"key":"10.1124\/dmd.104.002303_bib19","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1006\/bbrc.1996.1251","article-title":"cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3.","volume":"225","author":"Mojarrabi","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/dmd.104.002303_bib20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s007740050026","article-title":"Efficacy and safety of oral farecalcitriol in reducing parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.","volume":"16","author":"Morii","year":"1998","journal-title":"J Bone Miner Metab"},{"key":"10.1124\/dmd.104.002303_bib21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0169-6009(92)90823-V","article-title":"Biological potency of a fluorinated vitamin D analogue in hyperparathyroidism.","volume":"16","author":"Nakatsuka","year":"1992","journal-title":"Bone Miner"},{"key":"10.1124\/dmd.104.002303_bib22","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/carcin\/20.6.1107","article-title":"Glucuronidation of 2-hydroxy-amino-1-methyl-6-phenylimidazo[4,5-\u03b2] pyridine by human microsomal UDP-glucuronosyltrasferases: identification of specific UGT1A family isoforms involved.","volume":"20","author":"Nowell","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1124\/dmd.104.002303_bib23","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/S0006-2952(03)00190-4","article-title":"Metabolism of 26,26,26,27,27,27-F6-1\u03b1,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats.","volume":"65","author":"Sakaki","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.104.002303_bib24","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1006\/bbrc.2000.3050","article-title":"Metabolism of vitamin D3 by human CYP27A1.","volume":"273","author":"Sawada","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/dmd.104.002303_bib25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1042\/bj3380489","article-title":"Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.","volume":"338","author":"Strassburg","year":"1999","journal-title":"Biochem J"},{"key":"10.1124\/dmd.104.002303_bib26","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0003-9861(84)90161-9","article-title":"26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3: a highly potent, long-lasting analog of 1,25-dihydroxyvitamin D3.","volume":"229","author":"Tanaka","year":"1984","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.104.002303_bib27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev.pharmtox.40.1.581","article-title":"Human UDP-glucuronosyltransferases: metabolism, expression and disease.","volume":"40","author":"Tukey","year":"2000","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.104.002303_bib28","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1124\/dmd.30.12.1462","article-title":"Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10.","volume":"30","author":"Watanabe","year":"2002","journal-title":"Drug Metab Dispos"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624030824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624030824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.104.002303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T17:03:53Z","timestamp":1739898233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624030824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0090955624030824"],"URL":"https:\/\/doi.org\/10.1124\/dmd.104.002303","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"METABOLISM OF 26,26,26,27,27,27-F6-1\u03b1,23S,25-TRIHYDROXYVITAMIN D3 BY HUMAN UDP-GLUCURONOSYLTRANSFERASE 1A3*","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.104.002303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}