{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:39:33Z","timestamp":1791419973633,"version":"4.3.3"},"reference-count":40,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1124\/dmd.106.010033","type":"journal-article","created":{"date-parts":[[2006,7,13]],"date-time":"2006-07-13T00:44:46Z","timestamp":1152751486000},"page":"1756-1763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":287,"title":["Differential Regulation of Sinusoidal and Canalicular Hepatic Drug Transporter Expression by Xenobiotics Activating Drug-Sensing Receptors in Primary Human Hepatocytes"],"prefix":"10.1016","volume":"34","author":[{"given":"Emilie","family":"Jigorel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Le Vee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Boursier-Neyret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Parmentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Fardel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.106.010033_bib1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/dmd.105.006197","article-title":"The role of pregnane X receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice.","volume":"34","author":"Anapolsky","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.106.010033_bib2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1515\/BC.2005.060","article-title":"A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.","volume":"386","author":"Burk","year":"2005","journal-title":"Biol Chem"},{"key":"10.1124\/dmd.106.010033_bib3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1023\/B:PHAM.0000026420.79421.8f","article-title":"The complexities of hepatic drug transport: current knowledge and emerging concepts.","volume":"21","author":"Chandra","year":"2004","journal-title":"Pharm Res (NY)"},{"key":"10.1124\/dmd.106.010033_bib4","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1124\/dmd.105.003988","article-title":"Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.","volume":"33","author":"Cheng","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.106.010033_bib5","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1124\/dmd.31.11.1315","article-title":"Induction of multidrug resistance protein 3 (MRP3) in vivo is independent of constitutive androstane receptor.","volume":"31","author":"Cherrington","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.106.010033_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0006-2952(01)00829-2","article-title":"Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1\/2 and 3A1\/2 in phenobarbital-treated hepatocytes.","volume":"63","author":"Courtois","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.106.010033_bib7","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/carcin\/bgi139","article-title":"Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.","volume":"26","author":"Ebert","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1124\/dmd.106.010033_bib8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0076-6879(05)00028-5","article-title":"Coordinate transcriptional regulation of transport and metabolism.","volume":"400","author":"Eloranta","year":"2005","journal-title":"Methods Enzymol"},{"key":"10.1124\/dmd.106.010033_bib9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.biopha.2005.01.005","article-title":"Physiological, pharmacological and clinical features of the multidrug resistance protein 2.","volume":"59","author":"Fardel","year":"2005","journal-title":"Biomed Pharmacother"},{"key":"10.1124\/dmd.106.010033_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2004.12.003","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: a microarray study.","volume":"207","author":"Fletcher","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.106.010033_bib11","doi-asserted-by":"crossref","first-page":"14581","DOI":"10.1074\/jbc.M010173200","article-title":"Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin.","volume":"276","author":"Geick","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.106.010033_bib12","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2174\/1389200043335414","article-title":"Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.","volume":"5","author":"Gomez-Lechon","year":"2004","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.106.010033_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI6663","article-title":"The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin.","volume":"104","author":"Greiner","year":"1999","journal-title":"J Clin Investig"},{"key":"10.1124\/dmd.106.010033_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0005-2736(02)00633-8","article-title":"The superfamily of organic anion transporting polypeptides.","volume":"1609","author":"Hagenbuch","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.106.010033_bib15","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1124\/jpet.105.084830","article-title":"Bile salt export pump (BSEP\/ABCB11) can transport a nonbile acid substrate, pravastatin.","volume":"314","author":"Hirano","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.106.010033_bib16","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1124\/dmd.105.004762","article-title":"Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.","volume":"33","author":"Jigorel","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.106.010033_bib17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.103.053298","article-title":"Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1\u20133).","volume":"308","author":"Jonker","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.106.010033_bib18","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1074\/jbc.M109326200","article-title":"Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.","volume":"277","author":"Kast","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.106.010033_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0300-483X(01)00570-4","article-title":"Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression.","volume":"171","author":"Kauffmann","year":"2002","journal-title":"Toxicology"},{"key":"10.1124\/dmd.106.010033_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/1389200054633826","article-title":"Regulation of hepatic transporters by xenobiotic receptors.","volume":"6","author":"Klaassen","year":"2005","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.106.010033_bib21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1211\/0022357055966","article-title":"Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]).","volume":"57","author":"Kobayashi","year":"2005","journal-title":"J Pharm Pharmacol"},{"key":"10.1124\/dmd.106.010033_bib22","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0024-3205(87)90037-3","article-title":"Species differences in metabolism of ketotifen in rat, rabbit and man: demonstration of similar pathways in vivo and in cultured hepatocytes.","volume":"40","author":"Le Bigot","year":"1987","journal-title":"Life Sci"},{"key":"10.1124\/dmd.106.010033_bib23","doi-asserted-by":"crossref","first-page":"24780","DOI":"10.1074\/jbc.M111319200","article-title":"Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.","volume":"277","author":"Le Ferrec","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.106.010033_bib24","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0006-2952(02)01382-5","article-title":"Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes.","volume":"64","author":"Luttringer","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.106.010033_bib25","doi-asserted-by":"crossref","first-page":"17277","DOI":"10.1074\/jbc.M300138200","article-title":"Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.","volume":"278","author":"Maglich","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.106.010033_bib26","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1124\/dmd.105.003798","article-title":"Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver.","volume":"33","author":"Maher","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.106.010033_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0304-4165(02)00481-6","article-title":"Functional and structural comparison of PXR and CAR.","volume":"1619","author":"Moore","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.106.010033_bib28","first-page":"231","article-title":"Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.","volume":"53","author":"Morel","year":"1993","journal-title":"Cancer Res"},{"key":"10.1124\/dmd.106.010033_bib29","doi-asserted-by":"crossref","first-page":"23847","DOI":"10.1074\/jbc.R400004200","article-title":"Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.","volume":"279","author":"Nebert","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.106.010033_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/carcin\/bgh316","article-title":"Oltipraz regulates different categories of genes relevant to chemoprevention in human hepatocytes.","volume":"26","author":"Piton","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1124\/dmd.106.010033_bib31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cbi.2005.11.001","article-title":"Metabolism and transporter-mediated drug-drug interactions of the endothelin-A receptor antagonist CI-1034.","volume":"159","author":"Sahi","year":"2006","journal-title":"Chem-Biol Interact"},{"key":"10.1124\/dmd.106.010033_bib32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(02)00169-2","article-title":"Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.","volume":"55","author":"Schinkel","year":"2003","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1124\/dmd.106.010033_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/mc.2940120202","article-title":"Phenotypic variability in induction of P-glycoprotein mRNA by aromatic hydrocarbons in primary human hepatocytes.","volume":"12","author":"Schuetz","year":"1995","journal-title":"Mol Carcinog"},{"key":"10.1124\/dmd.106.010033_bib34","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1124\/dmd.30.8.892","article-title":"Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method.","volume":"30","author":"Shibata","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.106.010033_bib35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1146\/annurev.pharmtox.44.101802.121444","article-title":"Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs.","volume":"45","author":"Shitara","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.106.010033_bib36","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1124\/dmd.31.11.1296","article-title":"Induction of ABCC3 (MRP3) by pregnane X receptor activators.","volume":"31","author":"Teng","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.106.010033_bib37","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/physrev.00027.2002","article-title":"Bile salt transporters: molecular characterization, function, and regulation.","volume":"83","author":"Trauner","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1124\/dmd.106.010033_bib38","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.20784","article-title":"CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.","volume":"42","author":"Wagner","year":"2005","journal-title":"Hepatology"},{"key":"10.1124\/dmd.106.010033_bib39","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1124\/dmd.30.8.918","article-title":"Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1\/2 by phenobarbital.","volume":"30","author":"Xiong","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.106.010033_bib40","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1073\/pnas.0502530102","article-title":"Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception.","volume":"102","author":"Zelcer","year":"2005","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624036316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624036316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.106.010033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:10:30Z","timestamp":1739902230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624036316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0090955624036316"],"URL":"https:\/\/doi.org\/10.1124\/dmd.106.010033","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential Regulation of Sinusoidal and Canalicular Hepatic Drug Transporter Expression by Xenobiotics Activating Drug-Sensing Receptors in Primary Human Hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.106.010033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}