{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:30:42Z","timestamp":1772814642119,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1124\/dmd.106.010652","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T01:25:41Z","timestamp":1162430741000},"page":"262-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Recirculatory Pharmacokinetic Model of the Uptake, Distribution, and Bioavailability of Prochlorperazine Administered as a Thermally Generated Aerosol in a Single Breath to Dogs"],"prefix":"10.1016","volume":"35","author":[{"given":"Michael J.","family":"Avram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas K.","family":"Henthorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Spyker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom C.","family":"Krejcie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James V.","family":"Cassella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Rabinowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.106.010652_bib1","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1097\/00000542-200311000-00013","article-title":"Using front-end kinetics to optimize target-controlled drug infusions","volume":"99","author":"Avram","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1124\/dmd.106.010652_bib2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1124\/jpet.104.070094","article-title":"\u03b2-Adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution","volume":"311","author":"Avram","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.106.010652_bib3","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1097\/00000542-200006000-00036","article-title":"Isoflurane alters the recirculatory pharmacokinetics of physiologic markers","volume":"92","author":"Avram","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1124\/dmd.106.010652_bib4","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1097\/00000542-199712000-00018","article-title":"The effect of halothane on the recirculatory pharmacokinetics of physiologic markers","volume":"87","author":"Avram","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1124\/dmd.106.010652_bib5","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0026-0495(98)90064-6","article-title":"SAAM II: simulation, analysis, and modeling software for tracer and pharmacokinetic studies","volume":"47","author":"Barrett","year":"1998","journal-title":"Metabolism"},{"key":"10.1124\/dmd.106.010652_bib6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0196-0644(95)70001-3","article-title":"Randomized, placebo-controlled evaluation of prochlorperazine versus metoclopramide for emergency department treatment of migraine headache","volume":"26","author":"Coppola","year":"1995","journal-title":"Ann Emerg Med"},{"key":"10.1124\/dmd.106.010652_bib7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1365-2125.1991.tb03973.x","article-title":"Clinical pharmacology of prochlorperazine in healthy young males","volume":"32","author":"Isah","year":"1991","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.106.010652_bib8","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1001\/jama.1989.03420080094038","article-title":"Randomized double-blind trial of intravenous prochlorperazine for the treatment of acute headache","volume":"26","author":"Jones","year":"1989","journal-title":"J Am Med Assoc"},{"key":"10.1124\/dmd.106.010652_bib9","first-page":"541","article-title":"What determines anesthetic induction dose? It\u2019s the front-end kinetics, doctor!","volume":"89","author":"Krejcie","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1124\/dmd.106.010652_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1025780012960","article-title":"A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs","volume":"25","author":"Krejcie","year":"1997","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1124\/dmd.106.010652_bib11","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0022-3565(25)20752-2","article-title":"Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly","volume":"278","author":"Krejcie","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.106.010652_bib12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF02353481","article-title":"Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs","volume":"24","author":"Krejcie","year":"1996","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1124\/dmd.106.010652_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2125.1998.00035.x","article-title":"Pulmonary administration of aerosolized fentanyl: pharmacokinetic analysis of systemic delivery","volume":"46","author":"Mather","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.106.010652_bib14","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/jappl.1954.6.12.731","article-title":"On the theory of the indicator-dilution method for measurement of blood flow and volume","volume":"6","author":"Meier","year":"1954","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.106.010652_bib15","series-title":"International Encyclopedia of Pharmacological Therapy, Section 122: Pharmacokinetics: Theory and Methodology","first-page":"407","article-title":"Estimation of pharmacokinetic parameters: statistical considerations","author":"Metzler","year":"1986"},{"key":"10.1124\/dmd.106.010652_bib16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1124\/jpet.103.062893","article-title":"Fast onset medications through thermally generated aerosols","volume":"309","author":"Rabinowitz","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.106.010652_bib17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1067\/mem.2003.195","article-title":"Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial","volume":"41","author":"Tanen","year":"2003","journal-title":"Ann Emerg Med"},{"key":"10.1124\/dmd.106.010652_bib18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2125.1987.tb03021.x","article-title":"Preliminary studies of the pharmacokinetics and pharmacodynamics of prochlorperazine in healthy volunteers","volume":"23","author":"Taylor","year":"1987","journal-title":"Br J Clin Pharmacol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009095562401211X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009095562401211X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.106.010652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:19:01Z","timestamp":1739895541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009095562401211X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S009095562401211X"],"URL":"https:\/\/doi.org\/10.1124\/dmd.106.010652","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recirculatory Pharmacokinetic Model of the Uptake, Distribution, and Bioavailability of Prochlorperazine Administered as a Thermally Generated Aerosol in a Single Breath to Dogs","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.106.010652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}