{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:27:02Z","timestamp":1791268022409,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1124\/dmd.106.011775","type":"journal-article","created":{"date-parts":[[2006,9,30]],"date-time":"2006-09-30T01:10:13Z","timestamp":1159578613000},"page":"62-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Elevated Warfarin Metabolism in Warfarin-Resistant Roof Rats (Rattus rattus) in Tokyo"],"prefix":"10.1016","volume":"35","author":[{"given":"Mayumi","family":"Ishizuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumie","family":"Okajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Tanikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heewon","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki D.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro Q.","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.106.011775_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00008571-200305000-00002","article-title":"Pharmacogenetics of oral anticoagulants","volume":"13","author":"Daly","year":"2003","journal-title":"Pharmacogenetics"},{"key":"10.1124\/dmd.106.011775_bib2","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.2165\/00003088-200443150-00003","article-title":"Clinical pharmacology of bosentan, a dual endothelin receptor antagonist","volume":"43","author":"Dingemanse","year":"2004","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.106.011775_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/135475001452751","article-title":"P450 in wild animals as a biomarker of environmental impact","volume":"6","author":"Fujita","year":"2001","journal-title":"Biomarkers"},{"key":"10.1124\/dmd.106.011775_bib4","first-page":"17","article-title":"Warfarin resistance in the ship rat in Liverpool","volume":"15","author":"Greaves","year":"1973","journal-title":"Int Pest Control"},{"key":"10.1124\/dmd.106.011775_bib5","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1021\/bi00266a045","article-title":"Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone","volume":"21","author":"Guengerich","year":"1982","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.106.011775_bib6","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0090-9556(25)06832-1","article-title":"Debrisoquine\/sparteine-type polymorphic drug metabolism in wild Clethrionomys rufocanus","volume":"23","author":"Hoshi","year":"1995","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.106.011775_bib7","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1080\/004982598238921","article-title":"Effects of the agrochemicals butachlor, pretilachlor and isoprothiolane on rat liver xenobiotic-metabolizing enzymes","volume":"28","author":"Ishizuka","year":"1998","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.106.011775_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.7601\/mez.32.251","article-title":"Susceptibility of the roof rat, Rattus rattus, captured in several places to warfarin and scilliroside","volume":"32","author":"Ito","year":"1981","journal-title":"Jpn J Sanit Zool"},{"key":"10.1124\/dmd.106.011775_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1472-8206.2004.00301.x","article-title":"Herb-drug interactions: an overview of the clinical evidence","volume":"19","author":"Izzo","year":"2005","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1124\/dmd.106.011775_bib10","series-title":"Vitamin K Metabolism and Vitamin K-Dependent Proteins","first-page":"392","article-title":"Present distribution of anticoagulant resistance in the United States","author":"Jackson","year":"1979"},{"key":"10.1124\/dmd.106.011775_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0021-9258(19)86267-1","article-title":"Comparison of different forms of purified cytochrome P-450 from rat liver by immunological inhibition of regio- and stereoselective metabolism of warfarin","volume":"255","author":"Kaminsky","year":"1979","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.106.011775_bib12","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature (Lond)"},{"key":"10.1124\/dmd.106.011775_bib13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jbt.20104","article-title":"Warfarin resistance in a French strain of rats","volume":"19","author":"Lasseur","year":"2006","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1124\/dmd.106.011775_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/347103a0","article-title":"Image analysis for all","volume":"347","author":"Lennard","year":"1990","journal-title":"Nature (Lond)"},{"key":"10.1124\/dmd.106.011775_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.106.011775_bib16","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide-binding pigment of liver microsomes","volume":"269","author":"Omura","year":"1964","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.106.011775_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/oxfordjournals.jbchem.a129248","article-title":"A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes","volume":"67","author":"Omura","year":"1970","journal-title":"J Biochem"},{"key":"10.1124\/dmd.106.011775_bib18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0026-895X(24)12072-X","article-title":"Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators","volume":"58","author":"Pascussi","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.106.011775_bib19","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1534\/genetics.104.040360","article-title":"The genetic basis of resistance to anticoagulants in rodents","volume":"170","author":"Pelz","year":"2005","journal-title":"Genetics"},{"key":"10.1124\/dmd.106.011775_bib20","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature02214","article-title":"Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2","volume":"427","author":"Rost","year":"2004","journal-title":"Nature (Lond)"},{"key":"10.1124\/dmd.106.011775_bib21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00498250110060932","article-title":"Suppression of CYP3A2 mRNA expression in the warfarin-resistant roof rat, Rattus rattus: possible involvement of cytochrome P450 in the warfarin resistance mechanism","volume":"31","author":"Sugano","year":"2001","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.106.011775_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0378-4347(97)00346-0","article-title":"Determination of unbound warfarin enantiomers in human plasma and 7-hydroxywarfarin in human urine by chiral stationary-phase liquid chromatography with ultraviolet or fluorescence and on-line circular dichroism detection","volume":"701","author":"Takahashi","year":"1997","journal-title":"J Chromatogr B"},{"key":"10.1124\/dmd.106.011775_bib23","first-page":"49","article-title":"An eye-lens weight curve for determining age in black rats, Rattus rattus","volume":"18","author":"Tanikawa","year":"1993","journal-title":"J Mamm Soc Jpn"},{"key":"10.1124\/dmd.106.011775_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.7601\/mez.44.293","article-title":"An analysis of the lethal feeding period (LFP) of warfarin in several populations of roof rats, Rattus rattus","volume":"44","author":"Tanikawa","year":"1993","journal-title":"Jpn J Sanit Zool"},{"key":"10.1124\/dmd.106.011775_bib25","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1160\/TH04-02-0109","article-title":"Paracetamol (acetaminophen) warfarin interaction: NAPQ1, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle","volume":"92","author":"Thijssen","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1124\/dmd.106.011775_bib26","doi-asserted-by":"crossref","first-page":"25276","DOI":"10.1074\/jbc.M401645200","article-title":"The inhibitory effect of calumenin on the vitamin K-dependent \u03b3-carboxylation system: characterization of the system in normal and warfarin-resistant rats","volume":"279","author":"Wajih","year":"2004","journal-title":"J Biol Chem"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624011796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624011796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.106.011775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:16:16Z","timestamp":1739895376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624011796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0090955624011796"],"URL":"https:\/\/doi.org\/10.1124\/dmd.106.011775","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated Warfarin Metabolism in Warfarin-Resistant Roof Rats (Rattus rattus) in Tokyo","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.106.011775","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}