{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:03:38Z","timestamp":1791194618649,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1124\/dmd.107.017731","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T23:06:11Z","timestamp":1193699171000},"page":"294-302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Expression of Hepatic UDP-Glucuronosyltransferase 1A1 and 1A6 Correlated with Increased Expression of the Nuclear Constitutive Androstane Receptor and Peroxisome Proliferator-Activated Receptor \u03b1 in Male Rats Fed a High-Fat and High-Sucrose Diet"],"prefix":"10.1016","volume":"36","author":[{"given":"Makoto","family":"Osabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Sugatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Fukuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Ikushiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.107.017731_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/mol.63.1.119","article-title":"Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the aryl hydrocarbon receptor pathway","volume":"63","author":"Auyeung","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.107.017731_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1124\/dmd.106.012070","article-title":"Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice","volume":"35","author":"Buckley","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.107.017731_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/gast.2002.34168","article-title":"Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma","volume":"123","author":"Bugianesi","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.107.017731_bib4","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2003.50095","article-title":"Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis","volume":"37","author":"Chalasani","year":"2003","journal-title":"Hepatology"},{"key":"10.1124\/dmd.107.017731_bib5","doi-asserted-by":"crossref","first-page":"37973","DOI":"10.1074\/jbc.C200420200","article-title":"Crystal structure of the HNF4\u03b1 ligand binding domain in complex with endogenous fatty acid ligand","volume":"277","author":"Dhe-Paganon","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.107.017731_bib6","doi-asserted-by":"crossref","first-page":"26540","DOI":"10.1074\/jbc.M600931200","article-title":"Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor \u03b1, and the coactivator peroxisome proliferators-activated receptor \u03b3 coactivator-1\u03b1","volume":"281","author":"Ding","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.107.017731_bib7","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1053\/jhep.2003.50342","article-title":"CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease","volume":"38","author":"Emery","year":"2003","journal-title":"Hepatology"},{"key":"10.1124\/dmd.107.017731_bib8","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/jb\/117.2.392","article-title":"Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family (UGT1) gene complex","volume":"117","author":"Emi","year":"1995","journal-title":"J Biochem"},{"key":"10.1124\/dmd.107.017731_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0378-4347(92)80483-7","article-title":"Determination of paracetamol and its four major metabolites in mouse plasma by reversed-phase ion-pair high-performance liquid chromatography","volume":"573","author":"Esteban","year":"1992","journal-title":"J Chromatogr"},{"key":"10.1124\/dmd.107.017731_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/abbi.2000.1777","article-title":"Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract","volume":"377","author":"Grams","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.107.017731_bib11","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1124\/mol.65.5.1159","article-title":"Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression","volume":"65","author":"Hartley","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.107.017731_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1006\/abbi.1995.0039","article-title":"Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family (UGT1) isozyme in rat hepatic microsomes using anti-peptides antibodies","volume":"324","author":"Ikushiro","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.107.017731_bib13","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1021\/bi9702344","article-title":"Protein-protein interactions between UDP-glucuronosyltransferase isozymes in rat hepatic microsomes","volume":"36","author":"Ikushiro","year":"1997","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.107.017731_bib14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1124\/dmd.30.3.324","article-title":"Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases","volume":"30","author":"Kessler","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.107.017731_bib15","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1124\/jpet.104.081950","article-title":"UDP Glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5\u2032-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation","volume":"313","author":"Krishnaswamy","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.107.017731_bib16","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1172\/JCI8814","article-title":"CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis","volume":"105","author":"Leclercq","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1124\/dmd.107.017731_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/1389200033489442","article-title":"Regulation of UDP glucuronosyltransferase genes","volume":"4","author":"Mackenzie","year":"2003","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.107.017731_bib18","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0006-2952(90)90497-9","article-title":"Characterization of the hepatic responses to the short-term administration of ciprofibrate in several rat strain: co-induction of microsomal cytochrome P-450 IA1 and peroxisome proliferation","volume":"40","author":"Makowska","year":"1990","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.107.017731_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/138920006774832569","article-title":"Altered CYP expression and function in response to dietary factors: potential roles in disease pathogenesis","volume":"7","author":"Murray","year":"2006","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.107.017731_bib20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1021\/tx050317i","article-title":"Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15: potential implications in acetaminophen-induced hepatotoxicity","volume":"19","author":"Mutlib","year":"2006","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/dmd.107.017731_bib21","first-page":"G438","article-title":"Characterization of inducible nature of MRP3 in rat liver","volume":"278","author":"Ogawa","year":"2000","journal-title":"Am J Physiol"},{"key":"10.1124\/dmd.107.017731_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-5793(00)01840-8","article-title":"The gene for hepatocyte nuclear factor (HNF)-4\u03b1 is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver","volume":"478","author":"Oyadomari","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1124\/dmd.107.017731_bib23","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1093\/carcin\/bgi197","article-title":"Isoflavones modulate the glucuronidation of estradiol in human liver microsomes","volume":"26","author":"Pfeiffer","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1124\/dmd.107.017731_bib24","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2002-0012","article-title":"Peroxisome proliferator-activated receptor-\u03b3 coactivator 1\u03b1 (PGC-1\u03b1): transcriptional coactivator and metabolic regulator","volume":"24","author":"Puigserver","year":"2003","journal-title":"Endocr Rev"},{"key":"10.1124\/dmd.107.017731_bib25","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1081\/DMR-100101944","article-title":"Structural and functional studies of UDP-glucuronosyltransferases","volume":"31","author":"Radominska-Pandya","year":"1999","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.107.017731_bib26","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/dmd.106.013243","article-title":"Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor a activation","volume":"35","author":"Senekeo-Effenberger","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.107.017731_bib27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s00204-004-0569-9","article-title":"PPAR\u03b1-dependent modulation of hepatic CYP1A by clofibric acid in rats","volume":"78","author":"Shaban","year":"2004","journal-title":"Arch Toxicol"},{"key":"10.1124\/dmd.107.017731_bib28","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1124\/dmd.106.010397","article-title":"Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways","volume":"34","author":"Shelby","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.107.017731_bib29","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/jhep.2001.24172","article-title":"The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR","volume":"33","author":"Sugatani","year":"2001","journal-title":"Hepatology"},{"key":"10.1124\/dmd.107.017731_bib30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1124\/mol.104.007161","volume":"67","author":"Sugatani","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.107.017731_bib31","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1124\/dmd.106.010645","article-title":"Dietary inulin alleviates hepatic steatosis and xenobiotics-induced liver injury in rats fed a high-fat and high-sucrose diet association with the suppression of hepatic cytochrome P450 and hepatocyte nuclear factor 4a expression","volume":"34","author":"Sugatani","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.107.017731_bib32","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bcp.2003.11.002","article-title":"The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics","volume":"67","author":"Sugatani","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.107.017731_bib33","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nm815","article-title":"The orphan nuclear receptor HNF4a determines PXR- and CAR-mediated xenobiotic induction of CYP3A4","volume":"9","author":"Tirona","year":"2003","journal-title":"Nature Med"},{"key":"10.1124\/dmd.107.017731_bib34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev.pharmtox.40.1.581","article-title":"Human UDP-glucuronosyltransferases: metabolism, expression, and disease","volume":"40","author":"Tukey","year":"2000","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.107.017731_bib35","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1124\/dmd.31.6.773","article-title":"Induction of hepatic phase II drug-metabolizing enzymes by 1,7-phenanthroline in rats is accompanied by induction of MRP3","volume":"31","author":"Wang","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.107.017731_bib36","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0016-5085(96)70028-8","article-title":"Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation","volume":"111","author":"Weltman","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.107.017731_bib37","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1124\/dmd.30.9.962","article-title":"Mechanisms of impaired of biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarnital or phenobarbital pretreatment","volume":"30","author":"Xiong","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.107.017731_bib38","doi-asserted-by":"crossref","first-page":"15001","DOI":"10.1074\/jbc.M300645200","article-title":"Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1","volume":"278","author":"Yueh","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.107.017731_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.2002.9426","volume":"182","author":"Zhou","year":"2002","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624015654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624015654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.107.017731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:16:57Z","timestamp":1739895417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624015654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0090955624015654"],"URL":"https:\/\/doi.org\/10.1124\/dmd.107.017731","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of Hepatic UDP-Glucuronosyltransferase 1A1 and 1A6 Correlated with Increased Expression of the Nuclear Constitutive Androstane Receptor and Peroxisome Proliferator-Activated Receptor \u03b1 in Male Rats Fed a High-Fat and High-Sucrose Diet","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.107.017731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}