{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:07:43Z","timestamp":1773421663706,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1124\/dmd.108.022590","type":"journal-article","created":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T02:26:20Z","timestamp":1226024780000},"page":"338-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption"],"prefix":"10.1016","volume":"37","author":[{"given":"Masaaki","family":"Miyata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Hamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Yamazoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.108.022590_bib1","doi-asserted-by":"crossref","first-page":"G978","DOI":"10.1152\/ajpgi.00379.2004","article-title":"Cholesterol modulates human intestinal sodium-dependent bile acid transporter","volume":"288","author":"Alrefai","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/dmd.108.022590_bib2","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1126\/science.1093131","article-title":"Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption","volume":"303","author":"Altmann","year":"2004","journal-title":"Science"},{"key":"10.1124\/dmd.108.022590_bib3","doi-asserted-by":"crossref","first-page":"28857","DOI":"10.1074\/jbc.M011610200","article-title":"Human bile salt export pump promoter is transactivated by the farnesoid X receptor\/bile acid receptor","volume":"276","author":"Ananthanarayanan","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.022590_bib4","doi-asserted-by":"crossref","first-page":"G489","DOI":"10.1152\/ajpgi.00237.2007","article-title":"Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts","volume":"294","author":"Annaba","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/dmd.108.022590_bib5","doi-asserted-by":"crossref","first-page":"19909","DOI":"10.1074\/jbc.M207903200","article-title":"Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter","volume":"278","author":"Chen","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.022590_bib6","doi-asserted-by":"crossref","first-page":"33920","DOI":"10.1074\/jbc.M306370200","article-title":"Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice","volume":"278","author":"Dawson","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.022590_bib7","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1074\/jbc.M412752200","article-title":"The heteromeric organic solute transporter \u03b1-\u03b2, Ost\u03b1-Ost\u03b2, is an ileal basolateral bile acid transporter","volume":"280","author":"Dawson","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.022590_bib8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/gast.2001.25503","article-title":"The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp","volume":"121","author":"Denson","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.108.022590_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1210\/me.2005-0159","article-title":"The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-\u03b3 coactivator-1\u03b1, and suppressed by bile acids via a small heterodimer partner-dependent mechanism","volume":"20","author":"Eloranta","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1124\/dmd.108.022590_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1073\/pnas.0237082100","article-title":"Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor","volume":"100","author":"Goodwin","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/dmd.108.022590_bib11","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol Cell"},{"key":"10.1124\/dmd.108.022590_bib12","doi-asserted-by":"crossref","first-page":"45062","DOI":"10.1074\/jbc.M307145200","article-title":"Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity","volume":"278","author":"Guo","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.022590_bib13","series-title":"Bile Acids.","author":"Hofmann","year":"1994"},{"key":"10.1124\/dmd.108.022590_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.semcdb.2005.01.003","article-title":"Molecular mechanisms of cholesterol absorption and transport in the intestine","volume":"16","author":"Hui","year":"2005","journal-title":"Semin Cell Dev Biol"},{"key":"10.1124\/dmd.108.022590_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metab"},{"key":"10.1124\/dmd.108.022590_bib16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0005-2736(78)90440-6","article-title":"A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of D-glucose and choline transport systems","volume":"506","author":"Kessler","year":"1978","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.108.022590_bib17","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1194\/jlr.M700330-JLR200","article-title":"Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine","volume":"48","author":"Kim","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.108.022590_bib18","doi-asserted-by":"crossref","first-page":"17838","DOI":"10.1074\/jbc.M210634200","article-title":"Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity","volume":"278","author":"Kitada","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.022590_bib19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1053\/j.gastro.2003.06.005","article-title":"Enterohepatic bile salt transporters in normal physiology and liver disease","volume":"126","author":"Kullak-Ublick","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.108.022590_bib20","doi-asserted-by":"crossref","first-page":"G60","DOI":"10.1152\/ajpgi.00170.2004","article-title":"FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade","volume":"288","author":"Li","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/dmd.108.022590_bib21","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.metabol.2004.01.017","article-title":"Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase","volume":"53","author":"Li","year":"2004","journal-title":"Metabolism"},{"key":"10.1124\/dmd.108.022590_bib22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1097-2765(00)00050-2","article-title":"Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors","volume":"6","author":"Lu","year":"2000","journal-title":"Mol Cell"},{"key":"10.1124\/dmd.108.022590_bib23","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1124\/jpet.104.076158","article-title":"Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity","volume":"312","author":"Miyata","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.108.022590_bib24","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/00498250600776827","article-title":"Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity","volume":"36","author":"Miyata","year":"2006","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.108.022590_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.20295","article-title":"Bile acid-induced negative feedback regulation of the human ileal bile acid transporter","volume":"40","author":"Neimark","year":"2004","journal-title":"Hepatology"},{"key":"10.1124\/dmd.108.022590_bib26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2174\/156652407780059168","article-title":"Enzymes in the conversion of cholesterol into bile acids","volume":"7","author":"Norlin","year":"2007","journal-title":"Curr Mol Med"},{"key":"10.1124\/dmd.108.022590_bib27","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/hep.21359","article-title":"Hepatobiliary transporters and drug-induced cholestasis","volume":"44","author":"Pauli-Magnus","year":"2006","journal-title":"Hepatology"},{"key":"10.1124\/dmd.108.022590_bib28","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/0016-5085(81)90253-5","article-title":"Cholesterol absorption in cirrhosis: the role of total and individual bile acid pool size","volume":"80","author":"Ponz de Leon","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.108.022590_bib29","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1073\/pnas.0712328105","article-title":"The organic solute transporter \u03b1-\u03b2, Ost\u03b1-Ost\u03b2, is essential for intestinal bile acid transport and homeostasis","volume":"105","author":"Rao","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/dmd.108.022590_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"10.1124\/dmd.108.022590_bib31","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0022-2275(20)32171-4","article-title":"Marked reduction in bile acid synthesis in cholesterol 7\u03b1-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia","volume":"39","author":"Schwarz","year":"1998","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.108.022590_bib32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1172\/JCI117722","article-title":"Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter","volume":"95","author":"Shneider","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1124\/dmd.108.022590_bib33","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(00)00062-3","article-title":"Targeted disruption of the nuclear receptor FXR\/BAR impairs bile acid and lipid homeostasis","volume":"102","author":"Sinal","year":"2000","journal-title":"Cell"},{"key":"10.1124\/dmd.108.022590_bib34","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1073\/pnas.0409481102","article-title":"Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites","volume":"102","author":"Sonoda","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl 1","key":"10.1124\/dmd.108.022590_bib35","first-page":"S10","article-title":"Bile salt excretory pump: biology and pathobiology","volume":"43","author":"Suchy","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1124\/dmd.108.022590_bib36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.bjp.0707235","article-title":"Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis","volume":"151","author":"Teng","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1124\/dmd.108.022590_bib37","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1136\/gut.2005.085555","article-title":"Cholesterol dependent downregulation of mouse and human apical sodium dependent bile acid transporter (ASBT) gene expression: molecular mechanism and physiological consequences","volume":"55","author":"Thomas","year":"2006","journal-title":"Gut"},{"key":"10.1124\/dmd.108.022590_bib38","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1073\/pnas.0308426100","article-title":"Cholesterol feeding of mice expressing cholesterol 7\u03b1-hydroxylase increases bile acid pool size despite decreased enzyme activity","volume":"101","author":"Tiemann","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/dmd.108.022590_bib39","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1097\/01.mcg.0000155551.37266.26","article-title":"Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis","volume":"39","author":"Trauner","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"10.1124\/dmd.108.022590_bib40","doi-asserted-by":"crossref","first-page":"27228","DOI":"10.1074\/jbc.270.45.27228","article-title":"Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity","volume":"270","author":"Wong","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.022590_bib41","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1053\/j.gastro.2003.11.058","article-title":"Cholic acid supplementation enhances cholesterol absorption in humans","volume":"126","author":"Woollett","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.108.022590_bib42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/gut.2005.069906","article-title":"Micellar solubilisation of cholesterol is essential for absorption in humans","volume":"55","author":"Woollett","year":"2006","journal-title":"Gut"},{"key":"10.1124\/dmd.108.022590_bib43","doi-asserted-by":"crossref","first-page":"44931","DOI":"10.1074\/jbc.M400969200","article-title":"Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes","volume":"279","author":"Xia","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.022590_bib44","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0022-2275(20)32064-2","article-title":"Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits","volume":"41","author":"Xu","year":"2000","journal-title":"J Lipid Res"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624019433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624019433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.108.022590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:34:26Z","timestamp":1739896466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624019433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0090955624019433"],"URL":"https:\/\/doi.org\/10.1124\/dmd.108.022590","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.108.022590","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}