{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:57:25Z","timestamp":1791309445737,"version":"4.3.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1124\/dmd.108.023317","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T04:43:42Z","timestamp":1233981822000},"page":"1035-1045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice"],"prefix":"10.1016","volume":"37","author":[{"given":"Lisa D.","family":"Beilke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Aleksunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricky D.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Besselsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick D.","family":"Beger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis D.","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Cherrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.108.023317_bib1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/toxsci\/kfl050","article-title":"Tissue distribution and ontogeny of sulfotransferase enzymes in mice","volume":"93","author":"Alnouti","year":"2006","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.108.023317_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02703516","article-title":"Effects of ovulen-50, diethylnitrosamine and phenobarbital on liver regeneration in female rats","volume":"14","author":"Annapurna","year":"1989","journal-title":"J Biosci"},{"key":"10.1124\/dmd.108.023317_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1388-1981(99)00031-1","article-title":"6alpha-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes","volume":"1438","author":"Araya","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.108.023317_bib4","doi-asserted-by":"crossref","first-page":"22250","DOI":"10.1074\/jbc.M314111200","article-title":"Interactions between hepatic Mrp4 and SULT2a1\/2 as revealed by the constitutive androstane receptor and Mrp4 knockout mice","volume":"279","author":"Assem","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023317_bib5","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.3748\/wjg.v13.i42.5635","article-title":"Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse","volume":"13","author":"Baskin-Bey","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1124\/dmd.108.023317_bib6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/toxsci\/kfm287","article-title":"Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis","volume":"102","author":"Beilke","year":"2008","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.108.023317_bib7","doi-asserted-by":"crossref","first-page":"36688","DOI":"10.1074\/jbc.M304011200","article-title":"Tumor necrosis factor a-dependent up-regulation of Lrh-1 and Mrp3 (Abcc3) reduces liver injury in obstructive cholestasis","volume":"278","author":"Bohan","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023317_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1124\/dmd.106.012070","article-title":"Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice","volume":"35","author":"Buckley","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.108.023317_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0041-008X(91)90187-J","article-title":"Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. I. Lack of dependence on glutathione","volume":"109","author":"Davies","year":"1991","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.108.023317_bib10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/abio.2002.5637","article-title":"The comparison of plasma deproteinization methods for the detection of low-molecular weight metabolites by 1H nuclear magnetic resonance spectroscopy","volume":"304","author":"Daykin","year":"2002","journal-title":"Anal Biochem"},{"key":"10.1124\/dmd.108.023317_bib11","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2353\/ajpath.2006.050404","article-title":"Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice","volume":"168","author":"Fickert","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1124\/dmd.108.023317_bib12","doi-asserted-by":"crossref","first-page":"45062","DOI":"10.1074\/jbc.M307145200","article-title":"Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity","volume":"278","author":"Guo","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023317_bib13","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1073\/pnas.0630614100","article-title":"Induction of bilirubin clearance by the constitutive androstane receptor (CAR)","volume":"100","author":"Huang","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/dmd.108.023317_bib14","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1210\/me.2004-0520","article-title":"Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor","volume":"19","author":"Huang","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1124\/dmd.108.023317_bib15","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1007\/PL00014330","article-title":"Diagnosis and management of Crigler-Najjar syndrome","volume":"158","author":"Jansen","year":"1999","journal-title":"Eur J Pediatr"},{"key":"10.1124\/dmd.108.023317_bib16","doi-asserted-by":"crossref","first-page":"614","DOI":"10.2174\/138920008785821666","article-title":"New insights on the xenobiotic-sensing nuclear receptors in liver disease\u2013CAR and PXR\u2013","volume":"9","author":"Kakizaki","year":"2008","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.108.023317_bib17","doi-asserted-by":"crossref","first-page":"17838","DOI":"10.1074\/jbc.M210634200","article-title":"Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity","volume":"278","author":"Kitada","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023317_bib18","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1124\/dmd.105.003798","article-title":"Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver","volume":"33","author":"Maher","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.108.023317_bib19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/hep.21158","article-title":"Mrp4\u2013\/\u2013 mice have an impaired cytoprotective response in obstructive cholestasis","volume":"43","author":"Mennone","year":"2006","journal-title":"Hepatology"},{"key":"10.1124\/dmd.108.023317_bib20","series-title":"Guide for the Care and Use of Laboratory Animals","year":"1996"},{"key":"10.1124\/dmd.108.023317_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2174\/156652407780059168","article-title":"Enzymes in the conversion of cholesterol into bile acids","volume":"7","author":"Norlin","year":"2007","journal-title":"Curr Mol Med"},{"key":"10.1124\/dmd.108.023317_bib22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1055\/s-2007-1007351","article-title":"Bile acid metabolism and the pathophysiology of cholestasis","volume":"13","author":"Radominska","year":"1993","journal-title":"Semin Liver Dis"},{"key":"10.1124\/dmd.108.023317_bib23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"10.1124\/dmd.108.023317_bib24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1124\/mol.65.2.292","article-title":"A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification","volume":"65","author":"Saini","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.023317_bib25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hep.1840040416","article-title":"Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties\u2014studies on isolated hepatocytes and lipid membrane vesicles","volume":"4","author":"Sch\u00f6lmerich","year":"1984","journal-title":"Hepatology"},{"key":"10.1124\/dmd.108.023317_bib26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0076-6879(05)00022-4","article-title":"Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids","volume":"400","author":"Shonsey","year":"2005","journal-title":"Methods Enzymol"},{"key":"10.1124\/dmd.108.023317_bib27","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","article-title":"The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/dmd.108.023317_bib28","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1073\/pnas.0409794102","article-title":"Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury","volume":"102","author":"Stedman","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/dmd.108.023317_bib29","doi-asserted-by":"crossref","first-page":"11336","DOI":"10.1074\/jbc.M310258200","article-title":"Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice","volume":"279","author":"Stedman","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023317_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.bjp.0707235","article-title":"Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis","volume":"151","author":"Teng","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1124\/dmd.108.023317_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.61.1.1","article-title":"Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital","volume":"61","author":"Ueda","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.023317_bib32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/hep.21494","article-title":"Activation of LXRs prevents bile acid toxicity and cholestasis in female mice","volume":"45","author":"Uppal","year":"2007","journal-title":"Hepatology"},{"key":"10.1124\/dmd.108.023317_bib33","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.20784","article-title":"CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice","volume":"42","author":"Wagner","year":"2005","journal-title":"Hepatology"},{"key":"10.1124\/dmd.108.023317_bib34","doi-asserted-by":"crossref","first-page":"31441","DOI":"10.1074\/jbc.M200474200","article-title":"Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity","volume":"277","author":"Yu","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023317_bib35","doi-asserted-by":"crossref","first-page":"49517","DOI":"10.1074\/jbc.M409041200","article-title":"The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity","volume":"279","author":"Zhang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023317_bib36","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0168-8278(03)00228-9","article-title":"Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine","volume":"39","author":"Zollner","year":"2003","journal-title":"J Hepatol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624020439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624020439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.108.023317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:36:49Z","timestamp":1739896609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624020439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0090955624020439"],"URL":"https:\/\/doi.org\/10.1124\/dmd.108.023317","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.108.023317","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}