{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:42:52Z","timestamp":1790253772033,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1124\/dmd.108.023333","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:59:11Z","timestamp":1219971551000},"page":"2556-2563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Activation of the Aryl Hydrocarbon Receptor by the Calcium\/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a ]benz[de]isoquinoline-3-carboxylic Acid (STO-609)"],"prefix":"10.1016","volume":"36","author":[{"given":"Patricia","family":"Monteiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gilot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Langouet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Fardel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.108.023333_bib1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1124\/mol.65.4.934","article-title":"Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes","volume":"65","author":"Andrieux","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib2","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1124\/mol.65.2.416","article-title":"Different structural requirements of the ligand binding domain of the aryl hydrocarbon receptor for high- and low-affinity ligand binding and receptor activation","volume":"65","author":"Backlund","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib3","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1016\/j.febslet.2007.03.046","article-title":"The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein","volume":"581","author":"Barouki","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1124\/dmd.108.023333_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1615\/CritRevEukarGeneExpr.v18.i3.20","article-title":"The aryl hydrocarbon receptor complex and the control of gene expression","volume":"18","author":"Beischlag","year":"2008","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1124\/dmd.108.023333_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bcp.2006.01.017","article-title":"Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions","volume":"72","author":"Bock","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0026-895X(24)12541-2","article-title":"Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity","volume":"56","author":"Casper","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib7","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1074\/jbc.M411554200","article-title":"ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation","volume":"280","author":"Chen","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.pharmtox.43.100901.135828","article-title":"Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals","volume":"43","author":"Denison","year":"2003","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.108.023333_bib9","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1124\/mol.51.5.703","article-title":"Effect of transforming growth factor-beta1 on expression of aryl hydrocarbon receptor and genes of Ah gene battery: clues for independent down-regulation in A549 cells","volume":"51","author":"D\u00f6hr","year":"1997","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib10","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1158\/0008-5472.CAN-05-0628","article-title":"Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism","volume":"65","author":"Du","year":"2005","journal-title":"Cancer Res"},{"key":"10.1124\/dmd.108.023333_bib11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bcp.2007.09.013","article-title":"JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes","volume":"75","author":"Dvorak","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib12","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.exphem.2008.02.009","article-title":"A cascade of Ca2+\/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils","volume":"36","author":"Gaines","year":"2008","journal-title":"Exp Hematol"},{"key":"10.1124\/dmd.108.023333_bib13","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/S0006-2952(96)00600-4","article-title":"Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones, and related compounds","volume":"52","author":"Gasiewicz","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib14","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1002\/j.1460-2075.1995.tb00037.x","article-title":"Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase","volume":"14","author":"Haribabu","year":"1995","journal-title":"EMBO J"},{"key":"10.1124\/dmd.108.023333_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cbi.2007.12.005","article-title":"Role of mitogen-activated protein kinases in aryl hydrocarbon receptor signaling","volume":"172","author":"Henklov\u00e1","year":"2008","journal-title":"Chem Biol Interact"},{"key":"10.1124\/dmd.108.023333_bib16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev.pharmtox.41.1.471","article-title":"Ca2+\/CaM-dependent kinases: from activation to function","volume":"41","author":"Hook","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.108.023333_bib17","doi-asserted-by":"crossref","first-page":"29060","DOI":"10.1074\/jbc.M503824200","article-title":"The Ca2+\/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases","volume":"280","author":"Hurley","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib18","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1124\/dmd.31.11.1279","article-title":"The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor","volume":"31","author":"Joiakim","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.108.023333_bib19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.yjmcc.2006.04.011","article-title":"Using U0126 to dissect the role of the extracellular signal-regulated kinase 1\/2 (ERK1\/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes","volume":"41","author":"Kennedy","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/dmd.108.023333_bib20","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1038\/sj.onc.1207535","article-title":"Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins","volume":"23","author":"Knockaert","year":"2004","journal-title":"Oncogene"},{"key":"10.1124\/dmd.108.023333_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1012762519424","article-title":"Aryl hydrocarbon receptor\/dioxin receptor in human monocytes and macrophages","volume":"226","author":"Komura","year":"2001","journal-title":"Mol Cell Biochem"},{"key":"10.1124\/dmd.108.023333_bib22","doi-asserted-by":"crossref","first-page":"24780","DOI":"10.1074\/jbc.M111319200","article-title":"Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent","volume":"277","author":"Le Ferrec","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib23","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/j.1471-4159.2007.05098.x","article-title":"Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons","volume":"104","author":"Lin","year":"2008","journal-title":"J Neurochem"},{"key":"10.1124\/dmd.108.023333_bib24","doi-asserted-by":"crossref","first-page":"12391","DOI":"10.1074\/jbc.274.18.12391","article-title":"Protein kinase C modulates aryl hydrocarbon receptor nuclear translocator protein-mediated transactivation potential in a dimer context","volume":"274","author":"Long","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib25","doi-asserted-by":"crossref","first-page":"8432","DOI":"10.1074\/jbc.275.12.8432","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway: role of the transcription activaton and DNA binding of AhR","volume":"275","author":"Ma","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib26","doi-asserted-by":"crossref","first-page":"21473","DOI":"10.1074\/jbc.273.34.21473","article-title":"Characterization of the mechanism of regulation of Ca2+\/calmodulin-dependent protein kinase I by calmodulin and by Ca2+\/calmodulin-dependent protein kinase kinase","volume":"273","author":"Matsushita","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib27","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1124\/mol.107.037259","article-title":"The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems","volume":"72","author":"McMillan","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib28","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.bbrc.2007.04.111","article-title":"AhR- and c-maf-dependent induction of beta7-integrin expression in human macrophages in response to environmental polycyclic aromatic hydrocarbons","volume":"358","author":"Monteiro","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/dmd.108.023333_bib29","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1124\/mol.107.043125","article-title":"Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium\/calmodulin\/CaMKIalpha pathway","volume":"73","author":"Monteiro","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib30","doi-asserted-by":"crossref","first-page":"19906","DOI":"10.1074\/jbc.M601192200","article-title":"Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo-[a]pyrene","volume":"281","author":"N\u2032Diaye","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib31","doi-asserted-by":"crossref","first-page":"23847","DOI":"10.1074\/jbc.R400004200","article-title":"Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer","volume":"279","author":"Nebert","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib32","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.toxlet.2008.01.006","article-title":"Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation","volume":"177","author":"Podechard","year":"2008","journal-title":"Toxicol Lett"},{"key":"10.1124\/dmd.108.023333_bib33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0009-2797(02)00065-0","article-title":"The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation","volume":"141","author":"Pollenz","year":"2002","journal-title":"Chem Biol Interact"},{"key":"10.1124\/dmd.108.023333_bib34","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1124\/mol.53.3.438","article-title":"PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase","volume":"53","author":"Reiners","year":"1998","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.023333_bib35","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1074\/jbc.M005988200","article-title":"7-Ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor","volume":"276","author":"Savouret","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib36","doi-asserted-by":"crossref","first-page":"24064","DOI":"10.1074\/jbc.M401501200","article-title":"Calcium activation of ERK mediated by calmodulin kinase I","volume":"279","author":"Schmitt","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib37","doi-asserted-by":"crossref","first-page":"15813","DOI":"10.1074\/jbc.M201075200","article-title":"STO-609, a specific inhibitor of the Ca2+\/calmodulin-dependent protein kinase kinase","volume":"277","author":"Tokumitsu","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.023333_bib38","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.4049\/jimmunol.170.5.2374","article-title":"Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages","volume":"170","author":"van Grevenynghe","year":"2003","journal-title":"J Immunol"},{"key":"10.1124\/dmd.108.023333_bib39","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1074\/jbc.M509723200","volume":"281","author":"Wagner","year":"2006","journal-title":"J Biol Chem"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624018853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624018853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.108.023333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:33:50Z","timestamp":1739896430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624018853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0090955624018853"],"URL":"https:\/\/doi.org\/10.1124\/dmd.108.023333","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of the Aryl Hydrocarbon Receptor by the Calcium\/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a ]benz[de]isoquinoline-3-carboxylic Acid (STO-609)","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.108.023333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}