{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:54:53Z","timestamp":1771001693637,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1124\/dmd.108.025734","type":"journal-article","created":{"date-parts":[[2009,3,13]],"date-time":"2009-03-13T01:07:25Z","timestamp":1236906445000},"page":"1234-1241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Quantitative Prediction of in Vivo Profiles of CYP3A4 Induction in Humans from in Vitro Results with a Reporter Gene Assay"],"prefix":"10.1016","volume":"37","author":[{"given":"Masanari","family":"Kozawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Honma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.108.025734_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0009-9236(96)90018-1","article-title":"Rifampin drastically reduces plasma concentrations and effects of oral midazolam","volume":"59","author":"Backman","year":"1996","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.108.025734_bib2","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1124\/jpet.105.098160","article-title":"Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor","volume":"317","author":"Faucette","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.108.025734_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1124\/jpet.106.112136","article-title":"Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers","volume":"320","author":"Faucette","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.108.025734_bib4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2174\/1389200043335414","article-title":"Human hepatocytes in primary culture: the choice to investigate drug metabolism in man","volume":"5","author":"G\u00f3mez-Lech\u00f3n","year":"2004","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.108.025734_bib5","first-page":"1329","article-title":"The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module","volume":"56","author":"Goodwin","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.108.025734_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s004410100429","article-title":"Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions","volume":"306","author":"Hamilton","year":"2001","journal-title":"Cell Tissue Res"},{"key":"10.1124\/dmd.108.025734_bib7","series-title":"Goodman and Gilman\u2019s The Pharmacological Basis of Therapeutics","author":"Hardman","year":"2001"},{"key":"10.1124\/dmd.108.025734_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/03602530601093489","article-title":"Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies","volume":"39","author":"Hewitt","year":"2007","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.108.025734_bib9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/clpt.2008.132","article-title":"Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4\u03b2-hydroxycholesterol","volume":"84","author":"Kanebratt","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.108.025734_bib10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2133\/dmpk.20.236","article-title":"The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes","volume":"20","author":"Kato","year":"2005","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.108.025734_bib11","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1128\/MCB.19.9.6318","article-title":"Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene","volume":"19","author":"Kawamoto","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1124\/dmd.108.025734_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/(SICI)1099-0461(2000)14:4<177::AID-JBT1>3.0.CO;2-4","article-title":"Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes","volume":"14","author":"LeCluyse","year":"2000","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1124\/dmd.108.025734_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0887-2333(99)00096-X","article-title":"Regeneration and maintenance of bile canalicular networks in collagen-sandwiched hepatocytes","volume":"14","author":"LeCluyse","year":"2000","journal-title":"Toxicol In Vitro"},{"key":"10.1124\/dmd.108.025734_bib14","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/j.bcp.2004.07.041","article-title":"A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides","volume":"68","author":"Lemaire","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.108.025734_bib15","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1210\/mend.16.5.0828","article-title":"Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors","volume":"16","author":"Moore","year":"2002","journal-title":"Mol Endocrinol"},{"key":"10.1124\/dmd.108.025734_bib16","doi-asserted-by":"crossref","first-page":"15122","DOI":"10.1074\/jbc.M001215200","article-title":"Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands","volume":"275","author":"Moore","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.025734_bib17","first-page":"748","article-title":"Inhibition of CYP3A4 in a rapid microtiter plate assay using recombinant enzyme and in human liver microsomes using conventional substrates","volume":"29","author":"Nomeir","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.108.025734_bib18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2165\/00003088-200746080-00005","article-title":"General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs","volume":"46","author":"Ohno","year":"2007","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.108.025734_bib19","first-page":"270","article-title":"Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs","volume":"25","author":"Okuda","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.108.025734_bib20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.clpt.2006.08.013","article-title":"Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine","volume":"80","author":"Oscarson","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.108.025734_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.taap.2004.01.010","article-title":"The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes","volume":"199","author":"Parkinson","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.108.025734_bib22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2165\/00003088-199223020-00004","article-title":"Pharmacokinetic drug interactions of macrolides","volume":"23","author":"Periti","year":"1992","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.108.025734_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0168-8278(00)00085-4","article-title":"Drug biotransformation by human hepatocytes. In vitro\/in vivo metabolism by cells from the same donor","volume":"34","author":"Ponsoda","year":"2001","journal-title":"J Hepatol"},{"key":"10.1124\/dmd.108.025734_bib24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1006\/abbi.2001.2499","article-title":"Cytochrome P-450 mRNA expression in human liver and its relationship with enzyme activity","volume":"393","author":"Rodr\u00edguez-Antona","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.108.025734_bib25","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1124\/dmd.31.9.1093","article-title":"Comparative studies on the cytochrome P450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems","volume":"31","author":"Salonen","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.108.025734_bib26","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/0006-2952(94)90255-0","article-title":"Characterization of transport in isolated human hepatocytes: a study with the bile acid taurocholic acid, the uncharged ouabain and the organic cations vecuronium and rocuronium","volume":"47","author":"Sandker","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.108.025734_bib27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0378-4274(02)00374-0","article-title":"Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection","volume":"138","author":"Theil","year":"2003","journal-title":"Toxicol Lett"},{"key":"10.1124\/dmd.108.025734_bib28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.steroids.2006.12.006","article-title":"CAR and PXR: the xenobiotic-sensing receptors","volume":"72","author":"Timsit","year":"2007","journal-title":"Steroids"},{"key":"10.1124\/dmd.108.025734_bib29","doi-asserted-by":"crossref","first-page":"29295","DOI":"10.1074\/jbc.M400580200","article-title":"Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.108.025734_bib30","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1124\/dmd.104.002832","article-title":"Evaluation of time-dependent inactivation of CYP3A in cryopreserved human hepatocytes","volume":"33","author":"Zhao","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.108.025734_bib31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1582-4934.2002.tb00186.x","article-title":"Cytochromes P450 and experimental models of drug metabolism","volume":"6","author":"Zuber","year":"2002","journal-title":"J Cell Mol Med"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624020713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624020713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.108.025734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:38:07Z","timestamp":1739896687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624020713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0090955624020713"],"URL":"https:\/\/doi.org\/10.1124\/dmd.108.025734","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Prediction of in Vivo Profiles of CYP3A4 Induction in Humans from in Vitro Results with a Reporter Gene Assay","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.108.025734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}