{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:39:48Z","timestamp":1768617588031,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1124\/dmd.109.031518","type":"journal-article","created":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T01:11:13Z","timestamp":1270170673000},"page":"1072-1082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Transporter Studies with the 3-O-Sulfate Conjugate of 17\u03b1-Ethinylestradiol: Assessment of Human Liver Drug Transporters"],"prefix":"10.1016","volume":"38","author":[{"given":"Yong-Hae","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Busler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cliff","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. David","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.109.031518_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1023\/A:1013699130991","article-title":"Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3","volume":"19","author":"Akita","year":"2002","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.109.031518_bib2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0022-4731(80)90228-9","article-title":"Assay of ethynyloestradiol in human serum and its binding to plasma proteins","volume":"13","author":"Akpoviroro","year":"1980","journal-title":"J Steroid Biochem"},{"key":"10.1124\/dmd.109.031518_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0010-7824(80)90126-2","article-title":"The pharmacokinetics of a large (3 mg) oral dose of ethynylestradiol in women","volume":"21","author":"Back","year":"1980","journal-title":"Contraception"},{"key":"10.1124\/dmd.109.031518_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0010-7824(79)90098-2","article-title":"An investigation of the pharmacokinetics of ethynylestradiol in women using radioimmunoassay","volume":"20","author":"Back","year":"1979","journal-title":"Contraception"},{"key":"10.1124\/dmd.109.031518_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1357-2725(03)00236-X","article-title":"Multidrug resistance protein 4 (MRP4\/ABCC4) mediates efflux of bimane-glutathione","volume":"36","author":"Bai","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1124\/dmd.109.031518_bib6","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/hep.20961","article-title":"OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia","volume":"42","author":"Ballatori","year":"2005","journal-title":"Hepatology"},{"key":"10.1124\/dmd.109.031518_bib7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0168-8278(96)80246-7","article-title":"Multispecific amphipathic substrate transport by an organic anion transporter of human liver","volume":"25","author":"Bossuyt","year":"1996","journal-title":"J Hepatol"},{"key":"10.1124\/dmd.109.031518_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0010-7824(80)90120-1","article-title":"Serum levels of ethinylestradiol following its ingestion alone or in oral contraceptive formulations","volume":"22","author":"Brenner","year":"1980","journal-title":"Contraception"},{"key":"10.1124\/dmd.109.031518_bib9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1124\/jpet.103.062091","article-title":"Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3","volume":"309","author":"Chu","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.109.031518_bib10","doi-asserted-by":"crossref","first-page":"9626","DOI":"10.1074\/jbc.M004968200","article-title":"Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6","volume":"276","author":"Cui","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.109.031518_bib11","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/0024-3205(90)90431-P","article-title":"Metabolism of 17 alpha-ethynylestradiol in humans","volume":"47","author":"Guengerich","year":"1990","journal-title":"Life Sci"},{"key":"10.1124\/dmd.109.031518_bib12","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1124\/jpet.105.084830","article-title":"Bile salt export pump (BSEP\/ABCB11) can transport a nonbile acid substrate, pravastatin","volume":"314","author":"Hirano","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.109.031518_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1124\/jpet.104.068056","article-title":"Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans","volume":"311","author":"Hirano","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.109.031518_bib14","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/hep.510280528","article-title":"Adenosine triphosphate-dependent transport of estradiol-17beta(beta-d-glucuronide) in membrane vesicles by MDR1 expressed in insect cells","volume":"28","author":"Huang","year":"1998","journal-title":"Hepatology"},{"key":"10.1124\/dmd.109.031518_bib15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1124\/mol.64.3.610","article-title":"Breast cancer resistance protein exports sulfated estrogens but not free estrogens","volume":"64","author":"Imai","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.109.031518_bib16","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0022-3565(24)35228-0","article-title":"Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity","volume":"291","author":"Kim","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.109.031518_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.109.002014","article-title":"Xenobiotic, bile acid, and cholesterol transporters: function and regulation","volume":"62","author":"Klaassen","year":"2010","journal-title":"Pharmacol Rev"},{"key":"10.1124\/dmd.109.031518_bib18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1124\/jpet.103.051300","article-title":"Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane","volume":"306","author":"Kobayashi","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.109.031518_bib19","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1053\/gast.2001.21176","article-title":"Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver","volume":"120","author":"Kullak-Ublick","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.109.031518_bib20","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1046\/j.1365-2125.1999.00081.x","article-title":"Effects of cytochrome P450 inducers on 17alpha-ethinyloestradiol (EE2) conjugation by primary human hepatocytes","volume":"48","author":"Li","year":"1999","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.109.031518_bib21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3109\/00498258309052280","article-title":"The biliary and urinary metabolites of [3H]17 alpha-ethynylestradiol in women","volume":"13","author":"Maggs","year":"1983","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.109.031518_bib22","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1124\/jpet.105.085589","volume":"314","author":"Matsushima","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.109.031518_bib23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0010-7824(78)90031-8","article-title":"Ethinyl estradiol in peripheral plasma after oral administration of 30 microgram and 50 microgram to women","volume":"18","author":"Nilsson","year":"1978","journal-title":"Contraception"},{"key":"10.1124\/dmd.109.031518_bib24","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1124\/dmd.106.012930","article-title":"Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3","volume":"35","author":"No\u00e9","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.109.031518_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1124\/dmd.32.3.291","article-title":"Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity","volume":"32","author":"Nozawa","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.109.031518_bib26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0163-7258(89)90121-6","article-title":"Interindividual variation in the metabolism of ethynylestradiol","volume":"43","author":"Orme","year":"1989","journal-title":"Pharmacol Ther"},{"key":"10.1124\/dmd.109.031518_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2165\/00003088-198308020-00001","article-title":"Clinical pharmacokinetics of oral contraceptive steroids","volume":"8","author":"Orme","year":"1983","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.109.031518_bib28","doi-asserted-by":"crossref","first-page":"6404","DOI":"10.1074\/jbc.M008251200","article-title":"Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1","volume":"276","author":"Qian","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.109.031518_bib29","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2125.1987.tb03108.x","article-title":"Intestinal metabolism of ethinyloestradiol and paracetamol in vitro: studies using Ussing chambers","volume":"23","author":"Rogers","year":"1987","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.109.031518_bib30","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1074\/jbc.M109081200","article-title":"Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2\/SLC21A6) and multidrug resistance-associated protein 2 (MRP2\/ABCC2)","volume":"277","author":"Sasaki","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.109.031518_bib31","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1124\/dmd.32.11.1299","article-title":"Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol","volume":"32","author":"Schrag","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.109.031518_bib32","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1177\/0091270009337131","article-title":"The effect of etoricoxib on the pharmacokinetics of oral contraceptives in healthy participants","volume":"49","author":"Schwartz","year":"2009","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.109.031518_bib33","doi-asserted-by":"crossref","first-page":"27473","DOI":"10.1074\/jbc.M301106200","article-title":"Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta","volume":"278","author":"Seward","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.109.031518_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2133\/dmpk.18.33","article-title":"Function of uptake transporters for taurocholate and estradiol 17beta-d-glucuronide in cryopreserved human hepatocytes","volume":"18","author":"Shitara","year":"2003","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.109.031518_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bcp.2004.09.026","article-title":"Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2","volume":"69","author":"Spears","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.109.031518_bib36","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1210\/jcem.87.4.8431","article-title":"Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta","volume":"87","author":"St-Pierre","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1124\/dmd.109.031518_bib37","doi-asserted-by":"crossref","first-page":"22644","DOI":"10.1074\/jbc.M212399200","article-title":"ABCG2 transports sulfated conjugates of steroids and xenobiotics","volume":"278","author":"Suzuki","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.109.031518_bib38","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1023\/A:1013077609227","article-title":"Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C","volume":"18","author":"Tamai","year":"2001","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.109.031518_bib39","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1023\/A:1013070128668","article-title":"Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules","volume":"18","author":"Urakami","year":"2001","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.109.031518_bib40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2165\/00003088-200746020-00003","article-title":"Pharmacokinetic drug interactions involving 17alpha-ethinylestradiol: a new look at an old drug","volume":"46","author":"Zhang","year":"2007","journal-title":"Clin Pharmacokinet"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624024000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624024000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.109.031518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:49:58Z","timestamp":1739897398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624024000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0090955624024000"],"URL":"https:\/\/doi.org\/10.1124\/dmd.109.031518","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transporter Studies with the 3-O-Sulfate Conjugate of 17\u03b1-Ethinylestradiol: Assessment of Human Liver Drug Transporters","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.109.031518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}