{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:06:29Z","timestamp":1790233589960,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1124\/dmd.110.032854","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T00:49:29Z","timestamp":1275439769000},"page":"1493-1498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor"],"prefix":"10.1016","volume":"38","author":[{"given":"Daichi","family":"Takizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kakizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Tojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatomo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.110.032854_bib1","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.ejmech.2010.02.030","article-title":"Inside HDAC with HDAC inhibitors","volume":"45","author":"Bertrand","year":"2010","journal-title":"Eur J Med Chem"},{"key":"10.1124\/dmd.110.032854_bib2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.brainresbull.2005.01.004","article-title":"Microarray analysis of rat brain gene expression after chronic administration of sodium valproate","volume":"65","author":"Bosetti","year":"2004","journal-title":"Brain Res Bull"},{"key":"10.1124\/dmd.110.032854_bib3","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1124\/dmd.106.014456","article-title":"Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways","volume":"35","author":"Cerveny","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.032854_bib4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/sj.bjp.0706830","article-title":"The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver","volume":"149","author":"Eyal","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1124\/dmd.110.032854_bib5","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"G\u00f6ttlicher","year":"2001","journal-title":"EMBO J"},{"key":"10.1124\/dmd.110.032854_bib6","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1016\/j.bmc.2005.03.027","article-title":"Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis","volume":"13","author":"Hashimoto","year":"2005","journal-title":"Bioorg Med Chem"},{"key":"10.1124\/dmd.110.032854_bib7","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1074\/jbc.271.16.9746","article-title":"Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes","volume":"271","author":"Honkakoski","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.032854_bib8","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1128\/MCB.18.10.5652","article-title":"The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene","volume":"18","author":"Honkakoski","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1124\/dmd.110.032854_bib9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)80924-1","article-title":"Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines","volume":"92","author":"Kadonaga","year":"1998","journal-title":"Cell"},{"key":"10.1124\/dmd.110.032854_bib10","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/nar\/28.5.1126","article-title":"Tissue-specific chromatin structure of the phenobarbital-responsive unit and proximal promoter of CYP2B1\/2 and modulation by phenobarbital","volume":"28","author":"Kim","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/dmd.110.032854_bib11","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1124\/mol.64.5.1069","article-title":"Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells","volume":"64","author":"Kobayashi","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.110.032854_bib12","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1093\/emboj\/cdg315","article-title":"The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2","volume":"22","author":"Kr\u00e4mer","year":"2003","journal-title":"EMBO J"},{"key":"10.1124\/dmd.110.032854_bib13","doi-asserted-by":"crossref","first-page":"17277","DOI":"10.1074\/jbc.M300138200","article-title":"Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes","volume":"278","author":"Maglich","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.032854_bib14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0092-8674(00)80218-4","article-title":"Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase","volume":"89","author":"Nagy","year":"1997","journal-title":"Cell"},{"key":"10.1124\/dmd.110.032854_bib15","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.biocel.2007.03.001","article-title":"Histone deacetylase inhibitors: signalling towards p21cip1\/waf1","volume":"39","author":"Ocker","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1124\/dmd.110.032854_bib16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1081\/DMR-120026394","article-title":"Pathophysiological factors affecting CAR gene expression","volume":"35","author":"Pascussi","year":"2003","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.110.032854_bib17","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2125.2005.02529.x","article-title":"Clinically relevant drug interactions with antiepileptic drugs","volume":"61","author":"Perucca","year":"2006","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.110.032854_bib18","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.032854_bib19","first-page":"337","article-title":"Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases","volume":"231","author":"Rogiers","year":"1995","journal-title":"Eur J Biochem"},{"key":"10.1124\/dmd.110.032854_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF01962703","article-title":"Effects of valproate on xenobiotic biotransformation in rat liver. In vivo and in vitro experiments","volume":"14","author":"Rogiers","year":"1992","journal-title":"Pharm Weekbl Sci"},{"key":"10.1124\/dmd.110.032854_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/1389200013338595","article-title":"Induction of cytochromes P450","volume":"2","author":"Schuetz","year":"2001","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.110.032854_bib22","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1528-1157.1975.tb04738.x","article-title":"Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review","volume":"16","author":"Simon","year":"1975","journal-title":"Epilepsia"},{"key":"10.1124\/dmd.110.032854_bib23","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1074\/jbc.274.10.6043","article-title":"The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene","volume":"274","author":"Sueyoshi","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.032854_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.pharmtox.41.1.123","article-title":"Phenobarbital response elements of cytochrome P450 genes and nuclear receptors","volume":"41","author":"Sueyoshi","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.110.032854_bib25","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/jhep.2001.24172","article-title":"The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR","volume":"33","author":"Sugatani","year":"2001","journal-title":"Hepatology"},{"key":"10.1124\/dmd.110.032854_bib26","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1074\/jbc.M411318200","article-title":"Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells","volume":"280","author":"Swales","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.032854_bib27","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1210\/me.2003-0397","article-title":"CAR, driving into the future","volume":"18","author":"Swales","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.1124\/dmd.110.032854_bib28","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1128\/MCB.20.9.2951-2958.2000","article-title":"The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR","volume":"20","author":"Tzameli","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1124\/dmd.110.032854_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.61.1.1","article-title":"Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital","volume":"61","author":"Ueda","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.110.032854_bib30","doi-asserted-by":"crossref","first-page":"29295","DOI":"10.1074\/jbc.M400580200","article-title":"Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.032854_bib31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.0306-5251.2001.01474.x","article-title":"In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9)","volume":"52","author":"Wen","year":"2001","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.110.032854_bib32","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0026-895X(24)12588-6","article-title":"Induction of differentiation in F9 cells and activation of peroxisome proliferator-activated receptor delta by valproic acid and its teratogenic derivatives","volume":"59","author":"Werling","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.110.032854_bib33","doi-asserted-by":"crossref","first-page":"7197","DOI":"10.1158\/0008-5472.CAN-04-1459","article-title":"The orphan nuclear receptor constitutive active\/androstane receptor is essential for liver tumor promotion by phenobarbital in mice","volume":"64","author":"Yamamoto","year":"2004","journal-title":"Cancer Res"},{"key":"10.1124\/dmd.110.032854_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bbrc.2000.3557","article-title":"Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes","volume":"277","author":"Zelko","year":"2000","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624024619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624024619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.110.032854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:51:21Z","timestamp":1739897481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624024619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0090955624024619"],"URL":"https:\/\/doi.org\/10.1124\/dmd.110.032854","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.110.032854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}