{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T17:10:07Z","timestamp":1739898607788,"version":"3.37.3"},"reference-count":34,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1124\/dmd.110.033233","type":"journal-article","created":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T01:09:56Z","timestamp":1274231396000},"page":"1314-1321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["The N-Oxide Metabolite Contributes to Bladder Selectivity Resulting from Oral Propiverine: Muscarinic Receptor Binding and Pharmacokinetics"],"prefix":"10.1016","volume":"38","author":[{"given":"Shizuo","family":"Yamada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Taki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Seki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nanri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiaki","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikumi","family":"Komoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichiro","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.110.033233_bib1","series-title":"Investigative Urology","first-page":"157","article-title":"Effect of trospium chloride, oxybutynin and propiverine on the interaction of acetylcholine with isolated preparations of the human urinary bladder","author":"Alloussi","year":"1991"},{"key":"10.1124\/dmd.110.033233_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0031-6997(25)00442-9","article-title":"Pharmacology of lower urinary tract smooth muscles and penile erectile tissues","volume":"45","author":"Andersson","year":"1993","journal-title":"Pharmacol Rev"},{"key":"10.1124\/dmd.110.033233_bib3","first-page":"1","article-title":"The overactive bladder","volume":"11","author":"Bulmer","year":"2000","journal-title":"Rev Contemp Pharmacother"},{"key":"10.1124\/dmd.110.033233_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0090-4295(99)00492-6","article-title":"Muscarinic receptor antagonists in the treatment of overactive bladder","volume":"55","author":"Chapple","year":"2000","journal-title":"Urology"},{"key":"10.1124\/dmd.110.033233_bib5","first-page":"869","article-title":"Plasma pharmacokinetics and urinary excretion of propiverine hydrochloride in elderly population","volume":"34","author":"Cyong","year":"2006","journal-title":"Jpn Pharmacol Ther"},{"key":"10.1124\/dmd.110.033233_bib6","first-page":"428","article-title":"Treatment of urgency and incontinence in elderly patients with propiverine hydrochloride","volume":"13","author":"Halaska","year":"1994","journal-title":"Neurourol Urodynam"},{"key":"10.1124\/dmd.110.033233_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1254\/fpj.94.145","article-title":"Effects of propiverine hydrochloride and its metabolites on isolated guinea pig urinary bladder","volume":"94","author":"Haruno","year":"1989","journal-title":"Nippon Yakurigaku Zasshi"},{"key":"10.1124\/dmd.110.033233_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF03191308","article-title":"On the pharmacokinetics and metabolism of propiverine in man","volume":"13","author":"Haustein","year":"1988","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.110.033233_bib9","first-page":"91","article-title":"Studies on the metabolic pattern of propiverine in urine after single administration","volume":"43","author":"H\u00fcller","year":"1988","journal-title":"Pharmazie"},{"key":"10.1124\/dmd.110.033233_bib10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejphar.2009.04.068","article-title":"Demonstration of bladder muscarinic M3 receptor selectivity of oral solifenacin in muscarinic receptor knockout mice","volume":"615","author":"Ito","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/dmd.110.033233_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1254\/fpj.93.55","article-title":"Effect of propiverine hydrochloride on the function of the bladder in dogs","volume":"93","author":"Kaneko","year":"1989","journal-title":"Nippon Yakurigaku Zasshi"},{"key":"10.1124\/dmd.110.033233_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1254\/fpj.113.145","article-title":"Effects of propiverine hydrochloride (propiverine) on isolated rat and dog urinary bladder","volume":"113","author":"Kaneko","year":"1999","journal-title":"Nippon Yakurigaku Zasshi"},{"key":"10.1124\/dmd.110.033233_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jchromb.2003.10.029","article-title":"Validation of a simple liquid chromatography\u2013tandem mass spectrometric method for the determination of propiverine hydrochloride and its N-oxide metabolite in human plasma","volume":"799","author":"Komoto","year":"2004","journal-title":"J Chromatogr B Analyt Technol Diomed Life Sci"},{"key":"10.1124\/dmd.110.033233_bib14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"93","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.033233_bib15","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1046\/j.1464-410x.1999.00251.x","article-title":"A placebo-controlled, multicentre study comparing the tolerability and efficacy of propiverine and oxybutynin in patients with urgency and urge incontinence","volume":"84","author":"Madersbacher","year":"1999","journal-title":"BJU Int"},{"key":"10.1124\/dmd.110.033233_bib16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s003450100223","article-title":"Efficacy, tolerability and safety profile of propiverine in the treatment of the overactive bladder (non-neurogenic and neurogenic)","volume":"19","author":"Madersbacher","year":"2001","journal-title":"World J Urol"},{"key":"10.1124\/dmd.110.033233_bib17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.2042-7158.1997.tb06793.x","article-title":"In-vitro binding of propiverine hydrochloride and some of its metabolites to serum albumin in man","volume":"49","author":"Meisel","year":"1997","journal-title":"J Pharm Pharmacol"},{"key":"10.1124\/dmd.110.033233_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1254\/fpj.94.173","article-title":"Effects of propiverine hydrochloride (P-4) and its metabolites on urinary bladder function in anesthetized rats","volume":"94","author":"Nomura","year":"1989","journal-title":"Nippon Yakurigaku Zasshi"},{"key":"10.1124\/dmd.110.033233_bib19","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1097\/01.ju.0000138472.16876.8d","article-title":"Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder","volume":"172","author":"Oki","year":"2004","journal-title":"J Urol"},{"key":"10.1124\/dmd.110.033233_bib20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1248\/bpb.24.491","article-title":"Muscarinic receptor binding characteristics in rat tissues after oral administration of oxybutynin and propiverine","volume":"24","author":"Oki","year":"2001","journal-title":"Biol Pharm Bull"},{"key":"10.1124\/dmd.110.033233_bib21","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1056\/NEJM198509263131307","article-title":"Management of urinary incontinence in the elderly","volume":"313","author":"Resnick","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1124\/dmd.110.033233_bib22","first-page":"300","article-title":"The spasmolytic activity of propiverine and some of its structural analogs","volume":"37","author":"Riotte","year":"1987","journal-title":"Arzneimittelforschung"},{"key":"10.1124\/dmd.110.033233_bib23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.sc.3100750","article-title":"Efficacy and safety of propiverine in SCI-patients suffering from detrusor hyperreflexia\u2013a double-blind, placebo-controlled clinical trial","volume":"37","author":"St\u00f6hrer","year":"1999","journal-title":"Spinal Cord"},{"key":"10.1124\/dmd.110.033233_bib24","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1124\/dmd.105.005272","article-title":"Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers","volume":"33","author":"Tomalik-Scharte","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.033233_bib25","first-page":"3","article-title":"Pharmacokinetic studies of propiverine hydrochloride(5): animal differences in vivo, in vitro and protein binding.","volume":"6","author":"Tsuda","year":"1991","journal-title":"Xenobiotic Metab Dispos"},{"key":"10.1124\/dmd.110.033233_bib26","first-page":"76","article-title":"Comparison of the effects of various anticholinergic drugs on human isolated urinary bladder","volume":"330","author":"Wada","year":"1995","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1124\/dmd.110.033233_bib27","first-page":"652","article-title":"Studies on the metabolism of the bladder spasmolytic, propiverine (mictonorm) in humans","volume":"43","author":"Wengler","year":"1988","journal-title":"Pharmazie"},{"key":"10.1124\/dmd.110.033233_bib28","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/sj.bjp.0706244","article-title":"Pharmacodynamics of propiverine and three of its main metabolites on detrusor contraction","volume":"145","author":"Wuest","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1124\/dmd.110.033233_bib29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00210-006-0103-0","article-title":"Propiverine and metabolites: differences in binding to muscarinic receptors and in functional models of detrusor contraction","volume":"374","author":"Wuest","year":"2006","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/dmd.110.033233_bib30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0026-895X(25)13496-2","article-title":"Brain nicotinic acetylcholine receptors. Biochemical characterization by neosurugatoxin","volume":"28","author":"Yamada","year":"1985","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.110.033233_bib31","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1038\/sj.bjp.0705371","article-title":"In vitro and ex vivo effects of a selective nociceptin\/orphanin FQ (N\/OFQ) peptide receptor antagonist, CompB, on specific binding of [3H]N\/OFQ and [35S]GTP\u03b3S in rat brain and spinal cord","volume":"139","author":"Yamada","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1124\/dmd.110.033233_bib32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0022-3565(25)32274-3","article-title":"Characterization of alpha-1 adrenergic receptors in the heart using [3H]WB4101: effect of 6-hydroxydomine treatment","volume":"215","author":"Yamada","year":"1980","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.110.033233_bib33","first-page":"205","article-title":"Pharmacokinetic studies on propiverine hydrochloride\u2014metabolites in urinary bladder, other tissues, and urine of rats","volume":"10","author":"Yamamoto","year":"1995","journal-title":"Xenobiotic Metab Dispos"},{"key":"10.1124\/dmd.110.033233_bib34","first-page":"537","article-title":"Pharmacokinetic studies of propiverine hydrochloride (1) absorption, distribution, and excretion after a single administration to rats.","volume":"4","author":"Yamamoto","year":"1989","journal-title":"Xenobiotic Metab Dispos"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624024322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624024322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.110.033233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:50:55Z","timestamp":1739897455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624024322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0090955624024322"],"URL":"https:\/\/doi.org\/10.1124\/dmd.110.033233","relation":{},"ISSN":["0090-9556"],"issn-type":[{"type":"print","value":"0090-9556"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The N-Oxide Metabolite Contributes to Bladder Selectivity Resulting from Oral Propiverine: Muscarinic Receptor Binding and Pharmacokinetics","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.110.033233","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}