{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:13:14Z","timestamp":1785294794456,"version":"3.55.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1124\/dmd.110.034140","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T03:22:29Z","timestamp":1284693749000},"page":"2100-2104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["CYP3A4*16 and CYP3A4*18 Alleles Found in East Asians Exhibit Differential Catalytic Activities for Seven CYP3A4 Substrate Drugs"],"prefix":"10.1016","volume":"38","author":[{"given":"Keiko","family":"Maekawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Harakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Ryang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumika","family":"Aohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimie","family":"Sai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Katori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tohkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikihiko","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiro","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.110.034140_bib1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0022-3565(24)29199-0","article-title":"Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos","volume":"299","author":"Dai","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.110.034140_bib2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/humu.9210","article-title":"Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population","volume":"23","author":"Fukushima-Uesaka","year":"2004","journal-title":"Hum Mutat"},{"key":"10.1124\/dmd.110.034140_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pharmtox.39.1.1","article-title":"Cytochrome P-450 3A4: regulation and role in drug metabolism","volume":"39","author":"Guengerich","year":"1999","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.110.034140_bib4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cccn.2004.11.005","article-title":"CYP3A5*3 and CYP3A4*18 single nucleotide polymorphisms in a Chinese population","volume":"353","author":"Hu","year":"2005","journal-title":"Clin Chim Acta"},{"key":"10.1124\/dmd.110.034140_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/clpt.2008.215","article-title":"The CYP3A4*18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density","volume":"85","author":"Kang","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.110.034140_bib6","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1021\/bi9715627","article-title":"Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites","volume":"37","author":"Korzekwa","year":"1998","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.110.034140_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00008571-200203000-00006","article-title":"Common allelic variants of cytochrome P4503A4 and their prevalence in different populations","volume":"12","author":"Lamba","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1124\/dmd.110.034140_bib8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1124\/jpet.104.078758","article-title":"Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype","volume":"313","author":"Lee","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.110.034140_bib9","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1124\/dmd.107.016733","article-title":"The CYP3A4*18 allele, the most frequent coding variant in asian populations, does not significantly affect the midazolam disposition in heterozygous individuals","volume":"35","author":"Lee","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.034140_bib10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/00498250802617746","article-title":"Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine","volume":"39","author":"Maekawa","year":"2009","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.110.034140_bib11","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1124\/dmd.108.021816","article-title":"Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone","volume":"36","author":"Miyazaki","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.034140_bib12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2133\/dmpk.17.150","article-title":"CYP3A4 gene polymorphisms influence testosterone 6beta-hydroxylation","volume":"17","author":"Murayama","year":"2002","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.110.034140_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.clpt.2006.04.012","article-title":"Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer","volume":"80","author":"Nakajima","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.110.034140_bib14","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature","volume":"239","author":"Omura","year":"1964","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.034140_bib15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00008571-200007000-00001","article-title":"Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method","volume":"10","author":"Ozdemir","year":"2000","journal-title":"Pharmacogenetics"},{"key":"10.1124\/dmd.110.034140_bib16","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1080\/00498250802334391","article-title":"Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin","volume":"38","author":"Park","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.110.034140_bib17","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/S0021-9258(19)73803-4","article-title":"Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies","volume":"237","author":"Phillips","year":"1962","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.034140_bib18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cca.2007.05.004","article-title":"Genetic polymorphisms of CYP3A4: CYP3A4*18 allele is found in five healthy Malaysian subjects","volume":"383","author":"Ruzilawati","year":"2007","journal-title":"Clin Chim Acta"},{"key":"10.1124\/dmd.110.034140_bib19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00280-007-0634-1","article-title":"Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients","volume":"62","author":"Sai","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1124\/dmd.110.034140_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1089\/gte.2004.8.411","article-title":"Screening of 12 SNPs of CYP3A4 in a Chinese population using oligonucleotide microarray","volume":"8","author":"Wen","year":"2004","journal-title":"Genet Test"},{"key":"10.1124\/dmd.110.034140_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2133\/dmpk.18.267","article-title":"CYP3A4*18: it is not rare allele in Japanese population","volume":"18","author":"Yamamoto","year":"2003","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.110.034140_bib22","first-page":"161","article-title":"An analysis program MULTI(ELS) based on extended nonlinear least squares method for microcomputers","volume":"9","author":"Yamaoka","year":"1986","journal-title":"J Pharmacobiodyn"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624025492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624025492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.110.034140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:53:51Z","timestamp":1739897631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624025492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0090955624025492"],"URL":"https:\/\/doi.org\/10.1124\/dmd.110.034140","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CYP3A4*16 and CYP3A4*18 Alleles Found in East Asians Exhibit Differential Catalytic Activities for Seven CYP3A4 Substrate Drugs","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.110.034140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}