{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:25:02Z","timestamp":1758475502791,"version":"3.37.3"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1124\/dmd.110.037960","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T04:46:15Z","timestamp":1300769175000},"page":"1088-1096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent"],"prefix":"10.1016","volume":"39","author":[{"given":"Kazuya","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Umeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Horikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritaka","family":"Nakamichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihisa","family":"Ishiwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.110.037960_bib1","doi-asserted-by":"crossref","first-page":"31422","DOI":"10.1074\/jbc.M109.024489","article-title":"Interaction of organic cations with organic anion transporters","volume":"284","author":"Ahn","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.037960_bib2","article-title":"Effect of hepatic or renal impairment on eltrombopag pharmacokinetics","author":"Bauman","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.110.037960_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1124\/dmd.110.037960_bib4","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMoa073275","article-title":"Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura","volume":"357","author":"Bussel","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1124\/dmd.110.037960_bib5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/bdd.576","article-title":"Effects of tetraalkylammonium compounds with different affinities for organic cation transporters on the pharmacokinetics of metformin","volume":"28","author":"Choi","year":"2007","journal-title":"Biopharm Drug Dispos"},{"key":"10.1124\/dmd.110.037960_bib6","doi-asserted-by":"crossref","first-page":"9626","DOI":"10.1074\/jbc.M004968200","article-title":"Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6","volume":"276","author":"Cui","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.037960_bib7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s005350300007","article-title":"Influence of albumin binding on the substrate transport mediated by human hepatocyte transporters OATP2 and OATP8","volume":"38","author":"Cui","year":"2003","journal-title":"J Gastroenterol"},{"key":"10.1124\/dmd.110.037960_bib8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cld.2005.05.012","article-title":"Use of growth factors with antiviral therapy for chronic hepatitis C","volume":"9","author":"Curry","year":"2005","journal-title":"Clin Liver Dis"},{"key":"10.1124\/dmd.110.037960_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/1319-3767.58772","article-title":"Considerations in the management of hepatitis C virus-related thrombocytopenia with eltrombopag","volume":"16","author":"Danish","year":"2010","journal-title":"Saudi J Gastroenterol"},{"key":"10.1124\/dmd.110.037960_bib10","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1023\/A:1018943613122","article-title":"Physiological parameters in laboratory animals and humans","volume":"10","author":"Davies","year":"1993","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.110.037960_bib11","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1200\/JCO.2001.19.4.1137","article-title":"Incidence, cost, and outcomes of bleeding and chemotherapy dose modification among solid tumor patients with chemotherapy-induced thrombocytopenia","volume":"19","author":"Elting","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1124\/dmd.110.037960_bib12","first-page":"2912","article-title":"Biological activity and selectivity for TPO receptor of the orally bioavailable, small molecule TPO receptor agonist, SB-497115 (Abstract)","volume":"104","author":"Erickson-Miller","year":"2004","journal-title":"Blood (ASH Annu Meet Abstr)"},{"key":"10.1124\/dmd.110.037960_bib13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1634\/stemcells.2008-0366","article-title":"Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist","volume":"27","author":"Erickson-Miller","year":"2008","journal-title":"Stem Cells"},{"key":"10.1124\/dmd.110.037960_bib14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0090-9556(24)13357-0","article-title":"Delayed elimination of SN-38 in cancer patients with severe renal failure","volume":"39","author":"Fujita","year":"2011","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.037960_bib15","article-title":"Population pharmacokinetics of eltrombopag in healthy subjects and patients with chronic idiopathic thrombocytopenic purpura","author":"Gibiansky","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.110.037960_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/clpt.2009.236","article-title":"The International Transporter Consortium: a collaborative group of scientists from academia, industry, and the FDA","volume":"87","author":"Huang","year":"2010","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.110.037960_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0031-6997(24)01372-3","article-title":"Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver","volume":"50","author":"Ito","year":"1998","journal-title":"Pharmacol Rev"},{"key":"10.1124\/dmd.110.037960_bib18","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1182\/blood-2006-11-057968","article-title":"Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist","volume":"109","author":"Jenkins","year":"2007","journal-title":"Blood"},{"key":"10.1124\/dmd.110.037960_bib19","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1742-7843.2010.00581.x","article-title":"SLCO1B1 polymorphism and oral antidiabetic drugs","volume":"107","author":"Kalliokoski","year":"2010","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1124\/dmd.110.037960_bib20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0889-8588(05)70346-4","article-title":"The thrombocytopenia of cancer. Prospects for effective cytokine therapy","volume":"10","author":"Kaushansky","year":"1996","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1124\/dmd.110.037960_bib21","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1124\/dmd.108.021410","article-title":"Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin","volume":"36","author":"Kitamura","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.037960_bib22","first-page":"476","article-title":"Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update (Abstract)","volume":"108","author":"Kuter","year":"2006","journal-title":"Blood (ASH Annu Meet Abstr)"},{"key":"10.1124\/dmd.110.037960_bib23","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1182\/blood.V100.10.3457","article-title":"Recombinant human thrombopoietin: basic biology and evaluation of clinical studies","volume":"100","author":"Kuter","year":"2002","journal-title":"Blood"},{"key":"10.1124\/dmd.110.037960_bib24","doi-asserted-by":"crossref","first-page":"23390","DOI":"10.1074\/jbc.M502777200","article-title":"Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1","volume":"280","author":"Lan","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.037960_bib25","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1124\/dmd.105.009076","article-title":"Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism","volume":"34","author":"Lau","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.037960_bib26","first-page":"318","article-title":"A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia","volume":"76","author":"Lim","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1124\/dmd.110.037960_bib27","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1124\/dmd.104.001909","article-title":"Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms","volume":"33","author":"Nozawa","year":"2005","journal-title":"Drug Metab Dispos"},{"issue":"Suppl 3","key":"10.1124\/dmd.110.037960_bib28","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.3949\/ccjm.71.Suppl_3.S17","article-title":"Managing the hematologic side effects of antiviral therapy for chronic hepatitis C: anemia, neutropenia, and thrombocytopenia","volume":"71","author":"Ong","year":"2004","journal-title":"Cleve Clin J Med"},{"key":"10.1124\/dmd.110.037960_bib29","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0022-3565(25)20664-4","article-title":"Mechanism of stereoselective serum binding of ketoprofen after hemodialysis","volume":"278","author":"Sakai","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.110.037960_bib30","first-page":"2063","article-title":"Pharmacology and safety of SB-497115-GR, an orally active small molecular weight TPO receptor agonist, in chimpanzees, rats and dogs (Abstract)","volume":"104","author":"Sellers","year":"2004","journal-title":"Blood (ASH Annu Meet Abstr)"},{"key":"10.1124\/dmd.110.037960_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.clpt.2004.03.010","article-title":"Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine","volume":"76","author":"Simonson","year":"2004","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.110.037960_bib32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2133\/dmpk.21.375","article-title":"Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2","volume":"21","author":"Sugiura","year":"2006","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.110.037960_bib33","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1124\/dmd.110.032763","article-title":"Functional expression of carnitine\/organic cation transporter OCTN1\/SLC22A4 in mouse small intestine and liver","volume":"38","author":"Sugiura","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.037960_bib34","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1124\/dmd.107.020321","article-title":"PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice","volume":"36","author":"Sugiura","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.037960_bib35","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1093\/clinchem\/43.12.2274","article-title":"Effects of uremic toxins and fatty acids on serum protein binding of furosemide: possible mechanism of the binding defect in uremia","volume":"43","author":"Takamura","year":"1997","journal-title":"Clin Chem"},{"key":"10.1124\/dmd.110.037960_bib36","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1023\/A:1013077609227","article-title":"Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C","volume":"18","author":"Tamai","year":"2001","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.110.037960_bib37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1124\/dmd.108.024315","article-title":"Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1)","volume":"37","author":"van de Steeg","year":"2009","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.037960_bib38","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.clpt.2004.08.010","article-title":"Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand","volume":"76","author":"Wang","year":"2004","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.110.037960_bib39","doi-asserted-by":"crossref","first-page":"30143","DOI":"10.1074\/jbc.M503969200","article-title":"Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface","volume":"280","author":"Wang","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.110.037960_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1124\/dmd.109.030254","article-title":"Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans","volume":"38","author":"Watanabe","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.110.037960_bib41","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.clinthera.2009.04.010","article-title":"Effects of food and antacids on the pharmacokinetics of eltrombopag in healthy adult subjects: two single-dose, open-label, randomized-sequence, crossover studies","volume":"31","author":"Williams","year":"2009","journal-title":"Clin Ther"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009095562405791X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009095562405791X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.110.037960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:42:50Z","timestamp":1739904170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009095562405791X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S009095562405791X"],"URL":"https:\/\/doi.org\/10.1124\/dmd.110.037960","relation":{},"ISSN":["0090-9556"],"issn-type":[{"type":"print","value":"0090-9556"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.110.037960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}