{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:43:30Z","timestamp":1763747010980,"version":"3.37.3"},"reference-count":39,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1124\/dmd.111.039172","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T04:35:30Z","timestamp":1310013330000},"page":"1815-1822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases"],"prefix":"10.1016","volume":"39","author":[{"given":"Haiping","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.111.039172_bib1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.tiv.2006.12.006","article-title":"Protective role of dimethyl diphenyl bicarboxylate (DDB) against erythromycin induced hepatotoxicity in male rats","volume":"21","author":"Abdel-Hameid","year":"2007","journal-title":"Toxicol In Vitro"},{"key":"10.1124\/dmd.111.039172_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.pathophys.2008.09.003","article-title":"Prehepatic portal hypertension worsens the enterohepatic redox balance in thioacetamide-cirrhotic rats","volume":"15","author":"Aller","year":"2008","journal-title":"Pathophysiology"},{"key":"10.1124\/dmd.111.039172_bib3","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/hep.22394","article-title":"Functional magnetic resonance imaging monitoring of pathological changes in rodent livers during hyperoxia and hypercapnia","volume":"48","author":"Barash","year":"2008","journal-title":"Hepatology"},{"key":"10.1124\/dmd.111.039172_bib4","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1124\/dmd.105.005520","article-title":"Saturation toxicokinetics of thioacetamide: role in initiation of liver injury","volume":"33","author":"Chilakapati","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.039172_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0891-5849(03)00274-0","article-title":"Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins","volume":"35","author":"Chiu","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/dmd.111.039172_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1124\/dmd.30.2.129","article-title":"UDP glucuronosyltransferase mRNA levels in human liver disease","volume":"30","author":"Congiu","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.039172_bib7","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/0016-5085(95)90695-9","article-title":"Localization of uridine 5\u2032-diphosphate-glucuronosyltransferase in human liver injury","volume":"108","author":"Debinski","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.111.039172_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1440-1746.1996.tb01386.x","article-title":"UDP glucuronosyltransferase in the cirrhotic rat liver","volume":"11","author":"Debinski","year":"1996","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1124\/dmd.111.039172_bib9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1440-1746.1994.tb01254.x","article-title":"Release of latent glucuronosyltransferase activity contributes to the sparing of glucuronidation in experimental liver injuries","volume":"9","author":"Desmond","year":"1994","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1124\/dmd.111.039172_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/toxsci\/59.1.169","article-title":"High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes","volume":"59","author":"Enomoto","year":"2001","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.111.039172_bib11","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1478-3231.2005.01140.x","article-title":"Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice","volume":"25","author":"Gao","year":"2005","journal-title":"Liver Int"},{"key":"10.1124\/dmd.111.039172_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.chroma.2005.12.102","article-title":"Separation of atropisomers of anti-hepatitis drug dimethyl diphenyl bicarboxylate analogues by capillary electrophoresis with vancomycin as the chiral selector","volume":"1108","author":"Gao","year":"2006","journal-title":"J Chromatogr A"},{"key":"10.1124\/dmd.111.039172_bib13","doi-asserted-by":"crossref","first-page":"692","DOI":"10.2174\/138920009789895543","article-title":"Cytochrome P450 and steatosis","volume":"10","author":"G\u00f3mez-Lech\u00f3n","year":"2009","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.111.039172_bib14","doi-asserted-by":"crossref","first-page":"15028","DOI":"10.1016\/S0021-9258(17)43767-7","article-title":"The hepatic microsomal formation of bilirubin diglucuronide","volume":"258","author":"Gordon","year":"1983","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.111.039172_bib15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/138920007779816011","article-title":"Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation","volume":"8","author":"Hao","year":"2007","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.111.039172_bib16","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1124\/mol.106.027169","article-title":"Analysis of in vivo nuclear factor-kappaB activation during liver inflammation in mice: prevention by catalase delivery","volume":"71","author":"Hyoudou","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.111.039172_bib17","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/toxsci\/kfi113","article-title":"Enhancement by estradiol 3-benzoate in thioacetamide-induced liver cirrhosis of rats","volume":"85","author":"Kang","year":"2005","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.111.039172_bib18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.taap.2007.11.010","article-title":"Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity","volume":"228","author":"Kang","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.111.039172_bib19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s10620-009-0745-0","article-title":"Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis","volume":"55","author":"Karantonis","year":"2010","journal-title":"Dig Dis Sci"},{"key":"10.1124\/dmd.111.039172_bib20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11010-005-4539-1","article-title":"Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells","volume":"276","author":"Ko","year":"2005","journal-title":"Mol Cell Biochem"},{"key":"10.1124\/dmd.111.039172_bib21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1124\/dmd.110.035600","article-title":"Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes","volume":"39","author":"Koga","year":"2011","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.039172_bib22","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1002\/pmic.200400852","article-title":"A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers","volume":"4","author":"Low","year":"2004","journal-title":"Proteomics"},{"key":"10.1124\/dmd.111.039172_bib23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/clpt.2008.302","article-title":"Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics","volume":"85","author":"Morgan","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.111.039172_bib24","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1124\/jpet.105.094342","article-title":"Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats","volume":"316","author":"Mu","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.111.039172_bib25","first-page":"36","article-title":"Nicotine metabolism in liver microsomes from rats with acute hepatitis or cirrhosis","volume":"26","author":"Nakajima","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.039172_bib26","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/hep.21179","article-title":"Renal damage in experimentally-induced cirrhosis in rats: role of oxygen free radicals","volume":"43","author":"Natarajan","year":"2006","journal-title":"Hepatology"},{"key":"10.1124\/dmd.111.039172_bib27","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/hep.1840150621","article-title":"Changes of hepatic fatty acid metabolism produced by chronic thioacetamide administration in rats","volume":"15","author":"Nozu","year":"1992","journal-title":"Hepatology"},{"key":"10.1124\/dmd.111.039172_bib28","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0006-2952(96)00605-3","article-title":"Minimal effect of acute experimental hepatitis induced by lipopolysaccharide\/D-galactosamine on biotransformation in rats","volume":"52","author":"Omar","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.111.039172_bib29","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/j.1440-1746.1996.tb01841.x","article-title":"UDP-glucuronosyltransferase in the regenerating rat liver","volume":"11","author":"Pellizzer","year":"1996","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1124\/dmd.111.039172_bib30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1389200053586127","article-title":"A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years","volume":"6","author":"Radominska-Pandya","year":"2005","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.111.039172_bib31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1124\/dmd.105.007435","article-title":"Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney","volume":"34","author":"Richardson","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.039172_bib32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1472-8206.2010.00824.x","article-title":"Nilotinib counteracts thioacetamide-induced hepatic oxidative stress and attenuates liver fibrosis progression","volume":"25","author":"Shaker","year":"2011","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1124\/dmd.111.039172_bib33","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/tx700188x","article-title":"Carboxylic acid drug-induced DNA nicking in HEK293 cells expressing human UDP-glucuronosyltransferases: role of acyl glucuronide metabolites and glycation pathways","volume":"20","author":"Southwood","year":"2007","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/dmd.111.039172_bib34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.taap.2009.10.002","article-title":"Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats","volume":"242","author":"Tsai","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.111.039172_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/toxsci\/kfj076","article-title":"A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol","volume":"90","author":"Umemura","year":"2006","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.111.039172_bib36","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1124\/dmd.109.031864","article-title":"Regioselective glucuronidation of tanshinone iia after quinone reduction: identification of human UDP-glucuronosyltransferases, species differences, and interaction potential","volume":"38","author":"Wang","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.039172_bib37","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jep.2010.06.038","article-title":"Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers","volume":"131","author":"Xie","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"10.1124\/dmd.111.039172_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/toxsci\/kfp130","article-title":"Octachlorostyrene induces cytochrome P450, UDP-glucuronosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and constitutive androstane receptor","volume":"111","author":"Yanagiba","year":"2009","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.111.039172_bib39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/toxsci\/kfp115","article-title":"Introducing the \u201cTCDD-inducible AhR-Nrf2 gene battery\u201d","volume":"111","author":"Yeager","year":"2009","journal-title":"Toxicol Sci"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624224880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624224880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.111.039172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T20:01:15Z","timestamp":1739908875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624224880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0090955624224880"],"URL":"https:\/\/doi.org\/10.1124\/dmd.111.039172","relation":{},"ISSN":["0090-9556"],"issn-type":[{"type":"print","value":"0090-9556"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.111.039172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}