{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T20:40:28Z","timestamp":1739911228354,"version":"3.37.3"},"reference-count":17,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1124\/dmd.111.040683","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T11:21:00Z","timestamp":1314876060000},"page":"2165-2168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Correction for Nonspecific Binding to Various Components of Ultrafiltration Apparatus and Impact on Estimating In Vivo Rat Clearance for a Congeneric Series of 5-Ethyl, 5-n-Alkyl Barbituric Acids"],"prefix":"10.1016","volume":"39","author":[{"given":"Peter","family":"Ballard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.111.040683_bib1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1124\/dmd.30.12.1497","article-title":"The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties","volume":"30","author":"Austin","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.040683_bib2","first-page":"903","article-title":"Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam","volume":"25","author":"Carlile","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.040683_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/jps.2600790402","article-title":"Pharmacokinetic correlation between in vitro hepatic microsomal enzyme kinetics and in vivo metabolism of imipramine and desipramine in rats","volume":"79","author":"Chiba","year":"1990","journal-title":"J Pharm Sci"},{"key":"10.1124\/dmd.111.040683_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471141755.ph0705s34","article-title":"Determination of compound binding to plasma proteins","volume":"34","author":"Dow","year":"2006","journal-title":"Curr Protocols Pharm"},{"key":"10.1124\/dmd.111.040683_bib5","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1124\/dmd.105.007658","article-title":"Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement","volume":"34","author":"Hallifax","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.040683_bib6","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/0006-2952(94)90520-7","article-title":"Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance","volume":"47","author":"Houston","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.111.040683_bib7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3109\/03602539709002237","article-title":"Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices","volume":"29","author":"Houston","year":"1997","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.111.040683_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01059183","article-title":"Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital and thiopental in the rat","volume":"10","author":"Igari","year":"1982","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1124\/dmd.111.040683_bib9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1023\/A:1012036324237","article-title":"The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans","volume":"14","author":"Lav\u00e9","year":"1997","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.111.040683_bib10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2165\/00003088-199936030-00003","article-title":"Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations","volume":"36","author":"Lav\u00e9","year":"1999","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.111.040683_bib11","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1023\/A:1024406221962","article-title":"Modulation of nonspecific binding in ultrafiltration protein binding studies","volume":"20","author":"Lee","year":"2003","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.111.040683_bib12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2125.2000.00193.x","article-title":"Nonspecific binding of drugs to human liver microsomes","volume":"49","author":"McLure","year":"2000","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.111.040683_bib13","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0090-9556(24)14938-0","article-title":"Prediction of human clearance of twenty-nine drugs from hepatic microsomal clearance data: an examination of in vitro half-life approach and non-specific binding to microsomes","volume":"27","author":"Obach","year":"1999","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.040683_bib14","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1124\/dmd.105.004259","article-title":"A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes","volume":"33","author":"Riley","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.040683_bib15","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1080\/00498250802491662","article-title":"Determination of microsome and hepatocyte scaling factors for in vitro\/in vivo extrapolation in the rat and dog","volume":"38","author":"Smith","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.111.040683_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jpba.2005.10.031","article-title":"Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids","volume":"41","author":"Taylor","year":"2006","journal-title":"J Pharm Biomed Anal"},{"key":"10.1124\/dmd.111.040683_bib17","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0022-3565(25)33658-X","article-title":"Structure-pharmacokinetic relationships among the barbiturates in the rat","volume":"225","author":"Toon","year":"1983","journal-title":"J Pharm Exp Ther"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624225393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624225393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.111.040683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T20:02:53Z","timestamp":1739908973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624225393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0090955624225393"],"URL":"https:\/\/doi.org\/10.1124\/dmd.111.040683","relation":{},"ISSN":["0090-9556"],"issn-type":[{"type":"print","value":"0090-9556"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correction for Nonspecific Binding to Various Components of Ultrafiltration Apparatus and Impact on Estimating In Vivo Rat Clearance for a Congeneric Series of 5-Ethyl, 5-n-Alkyl Barbituric Acids","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.111.040683","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}