{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:08:29Z","timestamp":1791230909089,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1124\/dmd.111.040725","type":"journal-article","created":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T03:03:08Z","timestamp":1309316588000},"page":"1946-1953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Distribution of KAI-9803, a Novel \u03b4-Protein Kinase C Inhibitor, after Intravenous Administration to Rats"],"prefix":"10.1016","volume":"39","author":[{"given":"Yoshihiro","family":"Miyaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.111.040725_bib1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1126\/science.1072873","article-title":"Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions","volume":"298","author":"Aarts","year":"2002","journal-title":"Science"},{"key":"10.1124\/dmd.111.040725_bib2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.bbrc.2004.04.121","article-title":"Biodistribution of intracellularly acting peptides conjugated reversibly to Tat","volume":"318","author":"Begley","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/dmd.111.040725_bib3","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.1523\/JNEUROSCI.4474-03.2004","article-title":"Protein kinase C delta mediates cerebral reperfusion injury in vivo","volume":"24","author":"Bright","year":"2004","journal-title":"J Neurosci"},{"key":"10.1124\/dmd.111.040725_bib4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.brainres.2007.01.113","article-title":"DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo","volume":"1144","author":"Bright","year":"2007","journal-title":"Brain Res"},{"key":"10.1124\/dmd.111.040725_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ejps.2005.10.011","article-title":"The kinetics and tissue distribution of protein transduction in mice","volume":"27","author":"Cai","year":"2006","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/dmd.111.040725_bib6","doi-asserted-by":"crossref","first-page":"11114","DOI":"10.1073\/pnas.191369098","article-title":"Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC","volume":"98","author":"Chen","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.111.040725_bib7","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S1074-5521(01)00076-X","article-title":"Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7)","volume":"8","author":"Chen","year":"2001","journal-title":"Chem Biol"},{"key":"10.1124\/dmd.111.040725_bib8","doi-asserted-by":"crossref","first-page":"35109","DOI":"10.1074\/jbc.M301726200","article-title":"Antennapedia and HIV transactivator of transcription (TAT) \u201cprotein transduction domains\u201d promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans","volume":"278","author":"Console","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.111.040725_bib9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/CIRCULATIONAHA.107.759167","article-title":"Intracoronary KAI-9803 as a adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction","volume":"117","author":"Bates","year":"2008","journal-title":"Circulation"},{"key":"10.1124\/dmd.111.040725_bib10","first-page":"2013","article-title":"Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells","volume":"62","author":"Harada","year":"2002","journal-title":"Cancer Res"},{"key":"10.1124\/dmd.111.040725_bib11","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cardiores.2006.12.011","article-title":"Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage","volume":"73","author":"Ikeno","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1124\/dmd.111.040725_bib12","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1161\/01.CIR.0000101682.24138.36","article-title":"Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo","volume":"108","author":"Inagaki","year":"2003","journal-title":"Circulation"},{"key":"10.1124\/dmd.111.040725_bib13","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1161\/01.CIR.0000081943.93653.73","article-title":"Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator","volume":"108","author":"Inagaki","year":"2003","journal-title":"Circulation"},{"key":"10.1124\/dmd.111.040725_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2004.10.018","article-title":"Cationic TAT peptide transduction domain enters cells by macropinocytosis","volume":"102","author":"Kaplan","year":"2005","journal-title":"J Control Release"},{"key":"10.1124\/dmd.111.040725_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1126\/science.7716516","article-title":"Localization of protein kinases by anchoring proteins: a theme in signal transduction","volume":"268","author":"Mochly-Rosen","year":"1995","journal-title":"Science"},{"key":"10.1124\/dmd.111.040725_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1096\/fasebj.12.1.35","article-title":"Anchoring proteins for protein kinase C: a means for isozyme selectivity","volume":"12","author":"Mochly-Rosen","year":"1998","journal-title":"FASEB J"},{"key":"10.1124\/dmd.111.040725_bib17","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1126\/science.285.5433.1569","article-title":"In vivo protein transduction: delivery of a biologically active protein into the mouse","volume":"285","author":"Schwarze","year":"1999","journal-title":"Science"},{"key":"10.1124\/dmd.111.040725_bib18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0005-2795(71)90123-1","article-title":"Enzymatic iodination of polypeptides with 125I to high specific activity","volume":"251","author":"Thorell","year":"1971","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.111.040725_bib19","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1096\/fj.05-5523com","article-title":"Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells","volume":"20","author":"T\u00fcnnemann","year":"2006","journal-title":"FASEB J"},{"key":"10.1124\/dmd.111.040725_bib20","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1074\/jbc.M006701200","article-title":"Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans","volume":"276","author":"Tyagi","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.111.040725_bib21","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/90242","article-title":"The HIV TAT protein transduction domain improves the biodistribution of beta-glucuronidase expressed from recombinant viral vectors","volume":"19","author":"Xia","year":"2001","journal-title":"Nat Biotechnol"},{"key":"10.1124\/dmd.111.040725_bib22","doi-asserted-by":"crossref","first-page":"S205","DOI":"10.1097\/00005344-200036051-00062","article-title":"Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro","volume":"36","author":"Yuki","year":"2000","journal-title":"J Cardiovasc Pharmacol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624225034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624225034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.111.040725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T20:01:34Z","timestamp":1739908894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624225034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0090955624225034"],"URL":"https:\/\/doi.org\/10.1124\/dmd.111.040725","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distribution of KAI-9803, a Novel \u03b4-Protein Kinase C Inhibitor, after Intravenous Administration to Rats","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.111.040725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}