{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:04:54Z","timestamp":1769043894167,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1124\/dmd.111.040915","type":"journal-article","created":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T00:28:15Z","timestamp":1311035295000},"page":"1904-1909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese"],"prefix":"10.1016","volume":"39","author":[{"given":"Lan","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.111.040915_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.taap.2007.03.001","article-title":"Manganese: recent advances in understanding its transport and neurotoxicity","volume":"221","author":"Aschner","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.111.040915_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neuro.2005.10.007","article-title":"Manganese exposure: neuropsychological and neurological symptoms and effects in welders","volume":"27","author":"Bowler","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1124\/dmd.111.040915_bib3","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1212\/WNL.44.9.1583","article-title":"Manganism and idiopathic parkinsonism: similarities and differences","volume":"44","author":"Calne","year":"1994","journal-title":"Neurology"},{"key":"10.1124\/dmd.111.040915_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/archneur.1974.00490310061010","article-title":"Chronic manganese intoxication","volume":"30","author":"Cook","year":"1974","journal-title":"Arch Neurol"},{"key":"10.1124\/dmd.111.040915_bib5","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/nbm.931","article-title":"Manganese toxicity upon overexposure","volume":"17","author":"Crossgrove","year":"2004","journal-title":"NMR Biomed"},{"key":"10.1124\/dmd.111.040915_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1055\/s-0028-1103272","article-title":"ABC transporter (P-gp\/ABCB1, MRP1\/ABCC1, BCRP\/ABCG2) expression in the developing human CNS","volume":"39","author":"Daood","year":"2008","journal-title":"Neuropediatrics"},{"key":"10.1124\/dmd.111.040915_bib7","doi-asserted-by":"crossref","first-page":"26830","DOI":"10.1016\/S0021-9258(18)47094-9","article-title":"Structure-function studies of human arylamine N-acetyltransferases NAT1 and NAT2. Functional analysis of recombinant NAT1\/NAT2 chimeras expressed in Escherichia coli","volume":"269","author":"Dupret","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.111.040915_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj3480159","article-title":"Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2","volume":"348","author":"Goodfellow","year":"2000","journal-title":"Biochem J"},{"key":"10.1124\/dmd.111.040915_bib9","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jpba.2010.11.031","article-title":"HPLC analysis of para-aminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues","volume":"54","author":"Hong","year":"2011","journal-title":"J Pharm Biomed Anal"},{"key":"10.1124\/dmd.111.040915_bib10","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/01.jom.0000204114.01893.3e","article-title":"Effective treatment of manganese-induced occupational Parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study","volume":"48","author":"Jiang","year":"2006","journal-title":"J Occup Environ Med"},{"key":"10.1124\/dmd.111.040915_bib11","first-page":"66","article-title":"A report of two cases of chronic serious manganese poisoning treated with sodium para-aminosalicylic acid","volume":"49","author":"Ky","year":"1992","journal-title":"Br J Ind Med"},{"key":"10.1124\/dmd.111.040915_bib12","first-page":"433","article-title":"Manganese mineral interactions in brain","volume":"20","author":"Lai","year":"1999","journal-title":"Neurotoxicology"},{"key":"10.1124\/dmd.111.040915_bib13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuro.2006.02.003","article-title":"Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposure","volume":"27","author":"Li","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1124\/dmd.111.040915_bib14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pneurobio.2005.04.006","article-title":"Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases","volume":"76","author":"L\u00f6scher","year":"2005","journal-title":"Prog Neurobiol"},{"key":"10.1124\/dmd.111.040915_bib15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1056\/NEJMoa022928","article-title":"Community-based therapy for multidrug-resistant tuberculosis in Lima, Peru","volume":"348","author":"Mitnick","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1124\/dmd.111.040915_bib16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0161-813X(03)00081-0","article-title":"The nervous system effects of occupational exposure on workers in a South African manganese smelter","volume":"24","author":"Myers","year":"2003","journal-title":"Neurotoxicology"},{"key":"10.1124\/dmd.111.040915_bib17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cbpc.2009.11.005","article-title":"Effects of p-aminosalicylic acid on the neurotoxicity of manganese on the dopaminergic innervation of the cilia of the lateral cells of the gill of the bivalve mollusc, Crassostrea virginica","volume":"151","author":"Nelson","year":"2010","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10.1124\/dmd.111.040915_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-510X(02)00111-9","article-title":"Myoclonic involuntary movement associated with chronic manganese poisoning","volume":"199","author":"Ono","year":"2002","journal-title":"J Neurol Sci"},{"key":"10.1124\/dmd.111.040915_bib19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/toxsci\/kfl028","article-title":"Brain accumulation and toxicity of Mn(II) and Mn(III) exposures","volume":"93","author":"Reaney","year":"2006","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.111.040915_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1227\/01.NEU.0000255490.88321.CE","article-title":"The cerebrum. Anatomy","volume":"61","author":"Rhoton","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1124\/dmd.111.040915_bib21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s002040050380","article-title":"Influence of the route of administration and the chemical form (MnCl2, MnO2) on the absorption and cerebral distribution of manganese in rats","volume":"71","author":"Roels","year":"1997","journal-title":"Arch Toxicol"},{"key":"10.1124\/dmd.111.040915_bib22","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/01.STR.0000087786.38997.9E","article-title":"Vascular syndromes of the thalamus","volume":"34","author":"Schmahmann","year":"2003","journal-title":"Stroke"},{"key":"10.1124\/dmd.111.040915_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/taap.1999.8725","article-title":"The effects of CaNa(2)EDTA on brain lead mobilization in rodents determined using a stable lead isotope tracer","volume":"159","author":"Seaton","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.111.040915_bib24","first-page":"161","article-title":"One case on chronic serious manganism treated with sodium para-aminosalicylic acid [in Chinese]","volume":"18","author":"Shi","year":"2002","journal-title":"J Baotou Medical College"},{"key":"10.1124\/dmd.111.040915_bib25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1124\/mol.64.1.170","article-title":"Generation and functional characterization of arylamine N-acetyltransferase Nat1\/Nat2 double-knockout mice","volume":"64","author":"Sugamori","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.111.040915_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0169-409X(02)00172-2","article-title":"Drug efflux transporters in the CNS","volume":"55","author":"Sun","year":"2003","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1124\/dmd.111.040915_bib27","first-page":"163","article-title":"A report of one case on the diagnostic treatment with PAS-Na [in Chinese]","volume":"17","author":"Wu","year":"1991","journal-title":"Ind Health Occup Dis"},{"key":"10.1124\/dmd.111.040915_bib28","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1211\/jpp.61.11.0017","article-title":"Protective effects of sodium para-amino salicylate on manganese-induced neuronal death: the involvement of reactive oxygen species","volume":"61","author":"Yoon","year":"2009","journal-title":"J Pharm Pharmacol"},{"key":"10.1124\/dmd.111.040915_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0041-008X(03)00251-5","article-title":"Brain barrier systems: a new frontier in metal neurotoxicological research","volume":"192","author":"Zheng","year":"2003","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.111.040915_bib30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neuro.2008.12.007","article-title":"Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley rats","volume":"30","author":"Zheng","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1124\/dmd.111.040915_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0006-8993(99)01558-9","article-title":"Alteration of iron homeostasis following chronic exposure to manganese in rats","volume":"833","author":"Zheng","year":"1999","journal-title":"Brain Res"},{"key":"10.1124\/dmd.111.040915_bib32","first-page":"327","article-title":"The Clinical Observation on manganism treated with PAS-Na [in Chinese]","volume":"20","author":"Zhao","year":"1995","journal-title":"J Guiyang Medical College"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624224983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624224983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.111.040915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T20:01:25Z","timestamp":1739908885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624224983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0090955624224983"],"URL":"https:\/\/doi.org\/10.1124\/dmd.111.040915","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain Regional Pharmacokinetics of p-Aminosalicylic Acid and Its N-Acetylated Metabolite: Effectiveness in Chelating Brain Manganese","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.111.040915","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}