{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:13:21Z","timestamp":1789384401593,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1124\/dmd.111.042036","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T05:09:46Z","timestamp":1324530586000},"page":"617-624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs"],"prefix":"10.1016","volume":"40","author":[{"given":"Yaofeng","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpine","family":"Vapurcuyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shahidullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Aleksunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Pelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.111.042036_bib1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/clpt.1994.51","article-title":"Pharmacokinetics of famciclovir in subjects with varying degrees of renal impairment","volume":"55","author":"Boike","year":"1994","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.111.042036_bib2","doi-asserted-by":"crossref","first-page":"F792","DOI":"10.1152\/ajprenal.00360.2004","article-title":"Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions","volume":"288","author":"Burckhardt","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/dmd.111.042036_bib3","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0026-895X(24)12589-8","article-title":"Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney","volume":"59","author":"Cha","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.111.042036_bib4","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1124\/dmd.110.035865","article-title":"Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1\/2 and human toxic extrusion transporters 1\/2-k in vitro and in vivo","volume":"39","author":"Cheng","year":"2011","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.042036_bib5","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1124\/mol.107.043117","article-title":"Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP","volume":"73","author":"Cropp","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.111.042036_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0002-9343(82)90094-8","article-title":"Metabolic fate of radioactive acyclovir in humans","volume":"73","author":"de Miranda","year":"1982","journal-title":"Am J Med"},{"key":"10.1124\/dmd.111.042036_bib7","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1124\/jpet.301.3.797","article-title":"Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors","volume":"301","author":"Enomoto","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.111.042036_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/clpt.1986.177","article-title":"Human pharmacokinetics of the antiviral drug DHPG","volume":"40","author":"Fletcher","year":"1986","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.111.042036_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1042\/BJ20101904","article-title":"OAT2 catalyses efflux of glutamate and uptake of orotic acid","volume":"436","author":"Fork","year":"2011","journal-title":"Biochem J"},{"key":"10.1124\/dmd.111.042036_bib10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF02285093","article-title":"The tolerance to and pharmacokinetics of penciclovir (BRL 39,123A), a novel antiherpes agent, administered by intravenous infusion to healthy subjects","volume":"43","author":"Fowles","year":"1992","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.111.042036_bib11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","article-title":"Membrane transporters in drug development","volume":"9","author":"Giacomini","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/dmd.111.042036_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003088-199631010-00001","article-title":"The clinical pharmacokinetics of famciclovir","volume":"31","author":"Gill","year":"1996","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.111.042036_bib13","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0022-3565(24)37350-1","article-title":"Peritubular transport of ochratoxin A in rabbit renal proximal tubules","volume":"284","author":"Groves","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.111.042036_bib14","first-page":"F122","article-title":"Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney","volume":"276","author":"Hosoyamada","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1124\/dmd.111.042036_bib15","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1177\/00912709922008452","article-title":"Single-dose pharmacokinetics of valganciclovir in HIV- and CMV-seropositive subjects","volume":"39","author":"Jung","year":"1999","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.111.042036_bib16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1172\/JCI116972","article-title":"The human kidney low affinity Na+\/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for d-glucose","volume":"93","author":"Kanai","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1124\/dmd.111.042036_bib17","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1211\/0022357055966","article-title":"Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])","volume":"57","author":"Kobayashi","year":"2005","journal-title":"J Pharm Pharmacol"},{"key":"10.1124\/dmd.111.042036_bib18","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0002-9343(82)90091-2","article-title":"Influence of hemodialysis on acyclovir pharmacokinetics in patients with chronic renal failure","volume":"73","author":"Krasny","year":"1982","journal-title":"Am J Med"},{"key":"10.1124\/dmd.111.042036_bib19","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1681\/ASN.V134866","article-title":"Gene expression levels and immunolocalization of organic ion transporters in the human kidney","volume":"13","author":"Motohashi","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/dmd.111.042036_bib20","doi-asserted-by":"crossref","first-page":"17923","DOI":"10.1073\/pnas.0506483102","article-title":"A human transporter protein that mediates the final excretion step for toxic organic cations","volume":"102","author":"Otsuka","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.111.042036_bib21","doi-asserted-by":"crossref","first-page":"R1844","DOI":"10.1152\/ajpregu.2001.280.6.R1844","article-title":"Gill Na+-K+-2Cl\u2212 cotransporter abundance and location in Atlantic salmon: effects of seawater and smolting","volume":"280","author":"Pelis","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1124\/dmd.111.042036_bib22","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1124\/dmd.110.032664","article-title":"Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4","volume":"38","author":"Rius","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.111.042036_bib23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S1054-3589(08)60764-4","article-title":"The extraneuronal monoamine transporter exists in human central nervous system glia","volume":"42","author":"Sch\u00f6mig","year":"1998","journal-title":"Adv Pharmacol"},{"key":"10.1124\/dmd.111.042036_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0014-5793(98)00585-7","article-title":"Identification of multispecific organic anion transporter 2 expressed predominantly in the liver","volume":"429","author":"Sekine","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1124\/dmd.111.042036_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/jcs.107.4.1065","article-title":"Molecular cloning and characterization of a novel liver-specific transport protein","volume":"107","author":"Simonson","year":"1994","journal-title":"J Cell Sci"},{"issue":"Suppl 3","key":"10.1124\/dmd.111.042036_bib26","doi-asserted-by":"crossref","first-page":"S507","DOI":"10.1093\/clinids\/10.Supplement_3.S507","article-title":"Clinical pharmacokinetics of ganciclovir in patients with normal and impaired renal function","volume":"10","author":"Sommadossi","year":"1988","journal-title":"Rev Infect Dis"},{"key":"10.1124\/dmd.111.042036_bib27","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1128\/AAC.39.12.2759","article-title":"Absolute bioavailability and metabolic disposition of valaciclovir, the L-valyl ester of acyclovir, following oral administration to humans","volume":"39","author":"Soul-Lawton","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/dmd.111.042036_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1006\/bbrc.2001.4774","article-title":"Isolation of a family of organic anion transporters from human liver and kidney","volume":"283","author":"Sun","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/dmd.111.042036_bib29","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1124\/jpet.300.3.918","article-title":"Human organic anion transporters and human organic cation transporters mediate renal antiviral transport","volume":"300","author":"Takeda","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.111.042036_bib30","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1152\/physrev.00040.2003","article-title":"Molecular and cellular physiology of renal organic cation and anion transport","volume":"84","author":"Wright","year":"2004","journal-title":"Physiol Rev"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009095562422657X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009095562422657X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.111.042036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T20:07:07Z","timestamp":1739909227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009095562422657X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S009095562422657X"],"URL":"https:\/\/doi.org\/10.1124\/dmd.111.042036","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.111.042036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}