{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:45:15Z","timestamp":1767167115007,"version":"build-2238731810"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1124\/dmd.112.045674","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:04:43Z","timestamp":1353456283000},"page":"466-474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["RETRACTION: Immunohistochemical and Functional Characterization of Peptide, Organic Cation, Neutral and Basic Amino Acid, and Monocarboxylate Drug Transporters in Human Ocular Tissues"],"prefix":"10.1016","volume":"41","author":[{"given":"Rajendra S.","family":"Kadam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Vooturi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uday B.","family":"Kompella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.112.045674_bib1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1023\/A:1019806411610","article-title":"Mechanism of corneal permeation of L-valyl ester of acyclovir: targeting the oligopeptide transporter on the rabbit cornea","volume":"19","author":"Anand","year":"2002","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.112.045674_bib2","first-page":"2365","article-title":"Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells","volume":"39","author":"Basu","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/dmd.112.045674_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00726-006-0331-0","article-title":"The renal type H+\/peptide symporter PEPT2: structure-affinity relationships","volume":"31","author":"Biegel","year":"2006","journal-title":"Amino Acids"},{"key":"10.1124\/dmd.112.045674_bib4","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1046\/j.1432-1327.1999.00885.x","article-title":"Decisive structural determinants for the interaction of proline derivatives with the intestinal H+\/peptide symporter","volume":"266","author":"Brandsch","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1124\/dmd.112.045674_bib5","doi-asserted-by":"crossref","first-page":"C416","DOI":"10.1152\/ajpcell.00037.2004","article-title":"Expression of monocarboxylate transporters in rat ocular tissues","volume":"288","author":"Chidlow","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/dmd.112.045674_bib6","doi-asserted-by":"crossref","first-page":"e16411","DOI":"10.1371\/journal.pone.0016411","article-title":"MCT expression and lactate influx\/efflux in tanycytes involved in glia-neuron metabolic interaction","volume":"6","author":"Cort\u00e9s-Campos","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1124\/dmd.112.045674_bib7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2174\/156800805774912953","article-title":"Amino acid transporter ATB0,+ as a delivery system for drugs and prodrugs","volume":"5","author":"Ganapathy","year":"2005","journal-title":"Curr Drug Targets Immune Endocr Metabol Disord"},{"key":"10.1124\/dmd.112.045674_bib8","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1167\/iovs.07-1528","article-title":"Expression and localization of carnitine\/organic cation transporter OCTN1 and OCTN2 in ocular epithelium","volume":"49","author":"Garrett","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/dmd.112.045674_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","article-title":"Membrane transporters in drug development","volume":"9","author":"Giacomini","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/dmd.112.045674_bib10","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0022-3565(24)38156-X","article-title":"Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line","volume":"289","author":"Guo","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.112.045674_bib11","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1128\/MCB.19.3.1720","article-title":"Correlation between protein and mRNA abundance in yeast","volume":"19","author":"Gygi","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1124\/dmd.112.045674_bib12","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1021\/jm701175d","article-title":"Large neutral amino acid transporter enables brain drug delivery via prodrugs","volume":"51","author":"Gynther","year":"2008","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.112.045674_bib13","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1124\/jpet.103.057109","article-title":"Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery","volume":"308","author":"Hatanaka","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.112.045674_bib14","first-page":"1436","article-title":"Carrier-mediated transport of monocarboxylate drugs in the pigmented rabbit conjunctiva","volume":"39","author":"Horibe","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/dmd.112.045674_bib15","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1023\/A:1013310210710","article-title":"MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible route for delivery of monocarboxylic acid drugs to the retina","volume":"18","author":"Hosoya","year":"2001","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.112.045674_bib16","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1021\/mp0499499","article-title":"Identification of a Na+-dependent cationic and neutral amino acid transporter, B(0,+), in human and rabbit cornea","volume":"1","author":"Jain-Vakkalagadda","year":"2004","journal-title":"Mol Pharm"},{"key":"10.1124\/dmd.112.045674_bib17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1124\/jpet.111.181297","article-title":"Oxaliplatin transport mediated by organic cation\/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons","volume":"338","author":"Jong","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.112.045674_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.103.053298","article-title":"Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3)","volume":"308","author":"Jonker","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.112.045674_bib19","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1167\/iovs.10-6233","article-title":"Sclera-choroid-RPE transport of eight \u03b2-blockers in human, bovine, porcine, rabbit, and rat models","volume":"52","author":"Kadam","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/dmd.112.045674_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jchromb.2008.12.027","article-title":"Cassette analysis of eight beta-blockers in bovine eye sclera, choroid-RPE, retina, and vitreous by liquid chromatography-tandem mass spectrometry","volume":"877","author":"Kadam","year":"2009","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1124\/dmd.112.045674_bib21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/jop.2006.0150","article-title":"Dipeptide monoester ganciclovir prodrugs for transscleral drug delivery: targeting the oligopeptide transporter on rabbit retina","volume":"23","author":"Kansara","year":"2007","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1124\/dmd.112.045674_bib22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/BJ20080622","article-title":"Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy","volume":"414","author":"Karunakaran","year":"2008","journal-title":"Biochem J"},{"key":"10.1124\/dmd.112.045674_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11095-004-1193-3","article-title":"Metformin transport by renal basolateral organic cation transporter hOCT2","volume":"22","author":"Kimura","year":"2005","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.112.045674_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4155\/tde.10.40","article-title":"Recent advances in ophthalmic drug delivery","volume":"1","author":"Kompella","year":"2010","journal-title":"Ther Deliv"},{"key":"10.1124\/dmd.112.045674_bib25","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s11095-008-9730-0","article-title":"Transcorneal permeation of L- and D-aspartate ester prodrugs of acyclovir: delineation of passive diffusion versus transporter involvement","volume":"26","author":"Majumdar","year":"2009","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.112.045674_bib26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1089\/jop.2005.21.463","article-title":"Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations","volume":"21","author":"Majumdar","year":"2005","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1124\/dmd.112.045674_bib27","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1023\/A:1025741723724","article-title":"Preliminary investigation into the expression of proton-coupled oligopeptide transporters in neural retina and retinal pigment epithelium (RPE): lack of functional activity in RPE plasma membranes","volume":"20","author":"Ocheltree","year":"2003","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.112.045674_bib28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuint.2009.08.001","article-title":"Characteristics of glycine transport across the inner blood-retinal barrier","volume":"55","author":"Okamoto","year":"2009","journal-title":"Neurochem Int"},{"key":"10.1124\/dmd.112.045674_bib29","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1021\/jm7015683","article-title":"Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)","volume":"51","author":"Pedersen","year":"2008","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.112.045674_bib30","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1021\/mp2001878","article-title":"Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery","volume":"8","author":"Peura","year":"2011","journal-title":"Mol Pharm"},{"key":"10.1124\/dmd.112.045674_bib31","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1167\/iovs.02-0287","article-title":"Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells","volume":"44","author":"Philp","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/dmd.112.045674_bib32","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.addr.2004.07.008","article-title":"Peptide and peptide analog transport systems at the blood-CSF barrier","volume":"56","author":"Smith","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1124\/dmd.112.045674_bib33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrd3187","article-title":"Coexistence of passive and carrier-mediated processes in drug transport","volume":"9","author":"Sugano","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/dmd.112.045674_bib34","series-title":"Dipeptide Transport Mechanism in the Pigmented Rabbit Conjunctiva","author":"Sun","year":"1996"},{"key":"10.1124\/dmd.112.045674_bib35","series-title":"Membrane transport processes in the eye, in Ophthalmic Drug Delivery Systems","first-page":"13","author":"Sunkara","year":"2003"},{"key":"10.1124\/dmd.112.045674_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1023\/A:1018933324914","article-title":"Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism","volume":"11","author":"Tsuji","year":"1994","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.112.045674_bib37","first-page":"870","article-title":"Functional characterization of organic cation drug transport in the pigmented rabbit conjunctiva","volume":"41","author":"Ueda","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/dmd.112.045674_bib38","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1023\/B:PHAM.0000033019.49737.28","article-title":"Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+)","volume":"21","author":"Umapathy","year":"2004","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.112.045674_bib39","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1080\/00498250701397705","article-title":"Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates","volume":"37","author":"Umehara","year":"2007","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.112.045674_bib40","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/clpt.1993.196","article-title":"Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers","volume":"54","author":"Weller","year":"1993","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.112.045674_bib41","first-page":"1823","article-title":"Transport of L-carnitine in human corneal and conjunctival epithelial cells","volume":"16","author":"Xu","year":"2010","journal-title":"Mol Vis"},{"key":"10.1124\/dmd.112.045674_bib42","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1124\/dmd.108.021121","article-title":"Drug transporter and cytochrome P450 mRNA expression in human ocular barriers: implications for ocular drug disposition","volume":"36","author":"Zhang","year":"2008","journal-title":"Drug Metab Dispos"}],"updated-by":[{"DOI":"10.1124\/dmd.114.045674err","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"record-id":"4516"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624116236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624116236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.112.045674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T14:41:48Z","timestamp":1739889708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624116236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0090955624116236"],"URL":"https:\/\/doi.org\/10.1124\/dmd.112.045674","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTION: Immunohistochemical and Functional Characterization of Peptide, Organic Cation, Neutral and Basic Amino Acid, and Monocarboxylate Drug Transporters in Human Ocular Tissues","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.112.045674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}