{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:36:22Z","timestamp":1792236982568,"version":"4.4.0"},"reference-count":173,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1124\/dmd.115.063339","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T01:32:27Z","timestamp":1426123947000},"page":"788-802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["The 2014 Bernard B. Brodie Award Lecture\u2014Epoxide Hydrolases: Drug Metabolism to Therapeutics for Chronic Pain"],"prefix":"10.1016","volume":"43","author":[{"given":"Sean D","family":"Kodani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D","family":"Hammock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.115.063339_bib1","series-title":"Chronic Obstructive Pulmonary Disease Among Adults Aged 18 and Over in the United States, 1998-2009","author":"Akinbami","year":"2011"},{"key":"10.1124\/dmd.115.063339_bib2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.bmcl.2010.12.042","article-title":"1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia","volume":"21","author":"Anandan","year":"2011","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1124\/dmd.115.063339_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1081\/DMR-120026498","article-title":"The telltale structures of epoxide hydrolases","volume":"35","author":"Arand","year":"2003","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.115.063339_bib4","doi-asserted-by":"crossref","first-page":"15265","DOI":"10.1074\/jbc.M000278200","article-title":"Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation","volume":"275","author":"Argiriadi","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.115.063339_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0304-4165(86)90259-X","article-title":"Subcellular and organ distribution of cholesterol epoxide hydrolase in the rat","volume":"882","author":"Astr\u00f6m","year":"1986","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.115.063339_bib6","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1128\/JB.01348-09","article-title":"Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor","volume":"192","author":"Bahl","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1124\/dmd.115.063339_bib7","doi-asserted-by":"crossref","first-page":"14189","DOI":"10.1074\/jbc.M113.458414","article-title":"Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue","volume":"288","author":"Bettaieb","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.115.063339_bib8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0773.1989.tb01165.x","article-title":"In memoriam: Bernard B. Brodie","volume":"65","author":"Bickel","year":"1989","journal-title":"Pharmacol Toxicol"},{"key":"10.1124\/dmd.115.063339_bib9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0003-2697(79)90377-4","article-title":"A practical radiochromatographic assay for cholesterol epoxide hydrase","volume":"94","author":"Black","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1124\/dmd.115.063339_bib10","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1039\/C39790000420","article-title":"Interaction of 5\u03b1,6\u03b1-cholesterol oxide with DNA and other nucleophiles","author":"Blackburn","year":"1979","journal-title":"J Chem Soc Chem Commun"},{"key":"10.1124\/dmd.115.063339_bib11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/abio.1995.1520","article-title":"Improved radiolabeled substrates for soluble epoxide hydrolase","volume":"231","author":"Borhan","year":"1995","journal-title":"Anal Biochem"},{"key":"10.1124\/dmd.115.063339_bib12","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/245382a0","article-title":"Insect epoxide hydrase inhibition by juvenile hormone analogues and metabolic inhibitors","volume":"245","author":"Brooks","year":"1973","journal-title":"Nature"},{"key":"10.1124\/dmd.115.063339_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0306-3623(77)90016-7","article-title":"Epoxide hydratase as a modifier of biotransformation and biological activity","volume":"8","author":"Brooks","year":"1977","journal-title":"Gen Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0006-2952(70)90346-1","article-title":"Cyclodiene epoxide ring hydration by microsomes from mammalian liver and houseflies","volume":"19","author":"Brooks","year":"1970","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0014-2999(87)90445-6","article-title":"Vasoactivity of arachidonic acid epoxides","volume":"138","author":"Carroll","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib16","series-title":"Silent Spring","author":"Carson","year":"1962"},{"key":"10.1124\/dmd.115.063339_bib17","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0003-9861(83)90628-8","article-title":"The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase","volume":"223","author":"Chacos","year":"1983","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.115.063339_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.prostaglandins.2012.12.001","article-title":"Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model","volume":"104-105","author":"Chen","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1124\/dmd.115.063339_bib19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/FJC.0b013e3181506445","article-title":"The soluble epoxide hydrolase as a pharmaceutical target for hypertension","volume":"50","author":"Chiamvimonvat","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nn.2497","article-title":"Opioids activate brain analgesic circuits through cytochrome P450\/epoxygenase signaling","volume":"13","author":"Conroy","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1124\/dmd.115.063339_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pa.29.040189.000245","article-title":"Bernard B. Brodie and the rise of chemical pharmacology","volume":"29","author":"Costa","year":"1989","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.115.063339_bib22","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1073\/pnas.0437829100","article-title":"The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase","volume":"100","author":"Cronin","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib23","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.1021\/jm901063e","article-title":"Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases","volume":"52","author":"de Medina","year":"2009","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.115.063339_bib24","doi-asserted-by":"crossref","first-page":"13520","DOI":"10.1073\/pnas.1002922107","article-title":"Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands","volume":"107","author":"de Medina","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib25","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1038\/ncomms2835","article-title":"Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties","volume":"4","author":"de Medina","year":"2013","journal-title":"Nat Commun"},{"key":"10.1124\/dmd.115.063339_bib26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/oby.2009.227","article-title":"Expression and regulation of soluble epoxide hydrolase in adipose tissue","volume":"18","author":"De Taeye","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.1124\/dmd.115.063339_bib27","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1016\/S0021-9258(18)99606-7","article-title":"A soluble 2,3-oxidosqualene sterol cyclase","volume":"242","author":"Dean","year":"1967","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.115.063339_bib28","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1194\/jlr.M024448","article-title":"EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides","volume":"53","author":"Decker","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.115.063339_bib29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00204-009-0416-0","article-title":"Mammalian epoxide hydrolases in xenobiotic metabolism and signalling","volume":"83","author":"Decker","year":"2009","journal-title":"Arch Toxicol"},{"key":"10.1124\/dmd.115.063339_bib30","doi-asserted-by":"crossref","first-page":"e001015","DOI":"10.1161\/JAHA.114.001015","article-title":"Cardioprotection by controlling hyperamylinemia in a \u201chumanized\u201d diabetic rat model","volume":"3","author":"Despa","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"10.1124\/dmd.115.063339_bib31","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/01.fjc.0000189600.74157.6d","article-title":"An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats","volume":"46","author":"Dorrance","year":"2005","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib32","doi-asserted-by":"crossref","first-page":"36592","DOI":"10.1074\/jbc.M806315200","article-title":"Opposite regulation of cholesterol levels by the phosphatase and hydrolase domains of soluble epoxide hydrolase","volume":"283","author":"EnayetAllah","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.115.063339_bib33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1124\/jpet.105.085605","article-title":"Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors","volume":"314","author":"Fang","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.115.063339_bib34","doi-asserted-by":"crossref","first-page":"H2412","DOI":"10.1152\/ajpheart.00527.2004","article-title":"Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels","volume":"287","author":"Fang","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/dmd.115.063339_bib35","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/01.HYP.0000032278.75806.68","article-title":"Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats","volume":"40","author":"Fornage","year":"2002","journal-title":"Hypertension"},{"key":"10.1124\/dmd.115.063339_bib36","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/0006-291X(79)91872-2","article-title":"Hydration of cis- and trans-epoxymethyl stearates by the cytosolic epoxide hydrase of mouse liver","volume":"89","author":"Gill","year":"1979","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/dmd.115.063339_bib37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0006-2952(80)90518-3","article-title":"Distribution and properties of a mammalian soluble epoxide hydrase","volume":"29","author":"Gill","year":"1980","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib38","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/jf60193a058","article-title":"Mammalian metabolism and environmental degradation of the juvenoid 1-(4\u2032-ethylphenoxy)-3,7-dimethyl-6,7-epoxy-trans-2-octene and related compounds","volume":"22","author":"Gill","year":"1974","journal-title":"J Agric Food Chem"},{"key":"10.1124\/dmd.115.063339_bib39","series-title":"Insect Juvenile Hormones: Chemistry and Action","first-page":"177","article-title":"Preliminary chromatographic studies on the metabolites and photodecomposition products of the juvenoid 1-(4'-ethylphenoxy)-6,7-epoxy-3,7-dimethyl-2-octene","author":"Gill","year":"1972"},{"key":"10.1124\/dmd.115.063339_bib40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0003-2697(83)90166-5","article-title":"Radiometric assays for mammalian epoxide hydrolases and glutathione S-transferase","volume":"131","author":"Gill","year":"1983","journal-title":"Anal Biochem"},{"key":"10.1124\/dmd.115.063339_bib41","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/vaa.12030","article-title":"Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis","volume":"40","author":"Guedes","year":"2013","journal-title":"Vet Anaesth Analg"},{"key":"10.1124\/dmd.115.063339_bib42","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1016\/S0021-9258(19)69582-7","article-title":"Cytosolic and microsomal epoxide hydrolases are immunologically distinguishable from each other in the rat and mouse","volume":"256","author":"Guenthner","year":"1981","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.115.063339_bib43","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.prostaglandins.2007.01.006","article-title":"Structure and catalytic mechanisms of leukotriene A4 hydrolase","volume":"83","author":"Haeggstr\u00f6m","year":"2007","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1124\/dmd.115.063339_bib44","series-title":"Comprehensive Insect Physiology Biochemistry and Pharmacology","first-page":"431","article-title":"Regulation of juvenile hormone titer: degradation","author":"Hammock","year":"1985"},{"key":"10.1124\/dmd.115.063339_bib45","series-title":"Microsomes, Drug Oxidations, and Chemical Carcinogenesis","first-page":"655","article-title":"Extramicrosomal epoxide hydration","author":"Hammock","year":"1980"},{"key":"10.1124\/dmd.115.063339_bib46","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1021\/jf60193a043","article-title":"Synthesis and morphogenetic activity of derivaties and analogs of aryl geranyl ether juvenoids","volume":"22","author":"Hammock","year":"1974","journal-title":"J Agric Food Chem"},{"key":"10.1124\/dmd.115.063339_bib47","series-title":"Molecular Basis of Environmental Toxicology","first-page":"229","article-title":"Comparison of epoxide hydrases in the soluble and microsomal fractions of mammalian liver","author":"Hammock","year":"1980"},{"key":"10.1124\/dmd.115.063339_bib48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0305-0491(76)90045-6","article-title":"Soluble mammalian epoxide hydratase: action on juvenile hormone and other terpenoid epoxides","volume":"53","author":"Hammock","year":"1976","journal-title":"Comp Biochem Physiol B"},{"key":"10.1124\/dmd.115.063339_bib49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0076-6879(85)11018-9","article-title":"Epoxide hydrolases in the catabolism of sterols and isoprenoids","volume":"111","author":"Hammock","year":"1985","journal-title":"Methods Enzymol"},{"key":"10.1124\/dmd.115.063339_bib50","series-title":"The Juvenile Hormones","first-page":"374","article-title":"The degradative metabolism of juvenoids by insects","author":"Hammock","year":"1976"},{"key":"10.1124\/dmd.115.063339_bib51","series-title":"Comprehensive Toxicology","first-page":"283","article-title":"Epoxide hydrolases","author":"Hammock","year":"1997"},{"key":"10.1124\/dmd.115.063339_bib52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2217\/pmt.11.47","article-title":"The soluble epoxide hydrolase as a pharmaceutical target for pain management","volume":"1","author":"Hammock","year":"2011","journal-title":"Pain Manag"},{"key":"10.1124\/dmd.115.063339_bib53","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.01.016","article-title":"Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules","volume":"472","author":"Harris","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.115.063339_bib54","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.gene.2013.05.008","article-title":"Soluble epoxide hydrolase: gene structure, expression and deletion","volume":"526","author":"Harris","year":"2013","journal-title":"Gene"},{"key":"10.1124\/dmd.115.063339_bib55","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/ps\/85.2.278","article-title":"The cloning and characterization of a soluble epoxide hydrolase in chicken","volume":"85","author":"Harris","year":"2006","journal-title":"Poult Sci"},{"key":"10.1124\/dmd.115.063339_bib56","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1021\/jf60187a043","article-title":"Alkyl 3,7,11-trimethyl-2,4-dodecadienoates, a new class of potent insect growth regulators with juvenile hormone activity","volume":"21","author":"Henrick","year":"1973","journal-title":"J Agric Food Chem"},{"key":"10.1124\/dmd.115.063339_bib57","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/cvr\/cvr267","article-title":"N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase","volume":"93","author":"Hou","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1124\/dmd.115.063339_bib58","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbi.2014.07.016","article-title":"Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy","volume":"43","author":"Hung","year":"2015","journal-title":"Brain Behav Immun"},{"key":"10.1124\/dmd.115.063339_bib59","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1021\/jm2001376","article-title":"Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase","volume":"54","author":"Hwang","year":"2011","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.115.063339_bib60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.00021.2011","article-title":"Epoxides and soluble epoxide hydrolase in cardiovascular physiology","volume":"92","author":"Imig","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1124\/dmd.115.063339_bib61","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/nrd2875","article-title":"Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases","volume":"8","author":"Imig","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/dmd.115.063339_bib62","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.lfs.2006.07.031","article-title":"Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain","volume":"79","author":"Inceoglu","year":"2006","journal-title":"Life Sci"},{"key":"10.1124\/dmd.115.063339_bib63","doi-asserted-by":"crossref","first-page":"18901","DOI":"10.1073\/pnas.0809765105","article-title":"Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways","volume":"105","author":"Inceoglu","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib64","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1073\/pnas.1101073108","article-title":"Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP","volume":"108","author":"Inceoglu","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib65","doi-asserted-by":"crossref","first-page":"11390","DOI":"10.1073\/pnas.1208708109","article-title":"Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes","volume":"109","author":"Inceoglu","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib66","doi-asserted-by":"crossref","first-page":"e80922","DOI":"10.1371\/journal.pone.0080922","article-title":"Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures","volume":"8","author":"Inceoglu","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1124\/dmd.115.063339_bib67","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0003-9861(68)90020-9","article-title":"Role of the arene oxide-oxepin system in the metabolism of aromatic substrates. I. In vitro conversion of benzene oxide to a premercapturic acid and a dihydrodiol","volume":"128","author":"Jerina","year":"1968","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.115.063339_bib68","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1021\/ja00989a044","article-title":"Intramolecular migration of tritium and deuterium during nonenzymatic aromatic hydroxylation","volume":"89","author":"Jerina","year":"1967","journal-title":"J Am Chem Soc"},{"key":"10.1124\/dmd.115.063339_bib69","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1016\/j.bmcl.2006.07.009","article-title":"Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase","volume":"16","author":"Jones","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1124\/dmd.115.063339_bib70","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ab.2005.03.041","article-title":"Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies","volume":"343","author":"Jones","year":"2005","journal-title":"Anal Biochem"},{"key":"10.1124\/dmd.115.063339_bib71","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/01.HYP.0000153792.29478.1d","article-title":"Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension","volume":"45","author":"Jung","year":"2005","journal-title":"Hypertension"},{"key":"10.1124\/dmd.115.063339_bib72","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1021\/jm0500929","article-title":"Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility","volume":"48","author":"Kim","year":"2005","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.115.063339_bib73","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1021\/jm030514j","article-title":"Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility","volume":"47","author":"Kim","year":"2004","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.115.063339_bib74","doi-asserted-by":"crossref","first-page":"F971","DOI":"10.1152\/ajprenal.00256.2014","article-title":"Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation","volume":"307","author":"Kim","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/dmd.115.063339_bib75","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/1440-1681.12204","article-title":"Inhibition of soluble epoxide hydrolase is renoprotective in 5\/6 nephrectomized Ren-2 transgenic hypertensive rats","volume":"41","author":"Kujal","year":"2014","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1124\/dmd.115.063339_bib76","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0090-6980(83)90070-9","article-title":"Effects of newly reported arachidonic acid metabolites on microsomal Ca++ binding, uptake and release","volume":"26","author":"Kutsky","year":"1983","journal-title":"Prostaglandins"},{"key":"10.1124\/dmd.115.063339_bib77","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1021\/jm500694p","article-title":"Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy","volume":"57","author":"Lee","year":"2014","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.115.063339_bib78","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ab.2012.11.015","article-title":"F\u00f6rster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase","volume":"434","author":"Lee","year":"2013","journal-title":"Anal Biochem"},{"key":"10.1124\/dmd.115.063339_bib79","series-title":"Polycyclic Hydrocarbons and Carcinogenesis","first-page":"63","article-title":"The bay region theory of polycyclic aromatic hydrocarbon carcinogenesis","author":"Lehr","year":"1985"},{"key":"10.1124\/dmd.115.063339_bib80","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1073\/pnas.73.11.3867","article-title":"(+\/-)-Trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice","volume":"73","author":"Levin","year":"1976","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib81","doi-asserted-by":"crossref","first-page":"e94092","DOI":"10.1371\/journal.pone.0094092","article-title":"Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis","volume":"9","author":"Li","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1124\/dmd.115.063339_bib82","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1476-5381.2008.00009.x","article-title":"Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation","volume":"156","author":"Liu","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib83","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1073\/pnas.1422590112","article-title":"Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides","volume":"112","author":"L\u00f3pez-Vicario","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib84","doi-asserted-by":"crossref","first-page":"e23864","DOI":"10.1371\/journal.pone.0023864","article-title":"Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure","volume":"6","author":"Lundstr\u00f6m","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1124\/dmd.115.063339_bib85","doi-asserted-by":"crossref","first-page":"e33780","DOI":"10.1371\/journal.pone.0033780","article-title":"Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation","volume":"7","author":"Lundstr\u00f6m","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1124\/dmd.115.063339_bib86","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1124\/jpet.110.167544","article-title":"Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis","volume":"334","author":"Luo","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.115.063339_bib87","doi-asserted-by":"crossref","first-page":"9038","DOI":"10.1073\/pnas.1103482108","article-title":"Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance","volume":"108","author":"Luria","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib88","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.neuroscience.2009.06.033","article-title":"Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism","volume":"163","author":"Marowsky","year":"2009","journal-title":"Neuroscience"},{"key":"10.1124\/dmd.115.063339_bib89","doi-asserted-by":"crossref","first-page":"35826","DOI":"10.1074\/jbc.M114.588087","article-title":"Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7","volume":"289","author":"Matsumoto","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.115.063339_bib90","doi-asserted-by":"crossref","first-page":"13911","DOI":"10.1016\/S0021-9258(19)45318-0","article-title":"Leukotriene A4: preparation and enzymatic conversion in a cell-free system to leukotriene B4","volume":"257","author":"Maycock","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.115.063339_bib91","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1021\/jm301617j","article-title":"Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase","volume":"56","author":"Meirer","year":"2013","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.115.063339_bib92","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nm0597-562","article-title":"Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase","volume":"3","author":"Moghaddam","year":"1997","journal-title":"Nat Med"},{"key":"10.1124\/dmd.115.063339_bib93","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biochi.2012.06.011","article-title":"Role of epoxide hydrolases in lipid metabolism","volume":"95","author":"Morisseau","year":"2013","journal-title":"Biochimie"},{"key":"10.1124\/dmd.115.063339_bib94","doi-asserted-by":"crossref","first-page":"8849","DOI":"10.1073\/pnas.96.16.8849","article-title":"Potent urea and carbamate inhibitors of soluble epoxide hydrolases","volume":"96","author":"Morisseau","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib95","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S0006-2952(02)00952-8","article-title":"Structural refinement of inhibitors of urea-based soluble epoxide hydrolases","volume":"63","author":"Morisseau","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib96","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev.pharmtox.45.120403.095920","article-title":"Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles","volume":"45","author":"Morisseau","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.115.063339_bib97","first-page":"23","article-title":"Measurement of soluble epoxide hydrolase (sEH) activity","volume":"Chapter 4","author":"Morisseau","year":"2007","journal-title":"Curr Protoc Toxicol"},{"key":"10.1124\/dmd.115.063339_bib98","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/ps.1583","article-title":"Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical","volume":"64","author":"Morisseau","year":"2008","journal-title":"Pest Manag Sci"},{"key":"10.1124\/dmd.115.063339_bib99","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev-pharmtox-011112-140244","article-title":"Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health","volume":"53","author":"Morisseau","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.115.063339_bib100","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1194\/jlr.M006007","article-title":"Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids","volume":"51","author":"Morisseau","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.115.063339_bib101","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ab.2012.11.017","article-title":"Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries","volume":"434","author":"Morisseau","year":"2013","journal-title":"Anal Biochem"},{"key":"10.1124\/dmd.115.063339_bib102","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/0003-2697(80)90551-5","article-title":"A rapid radiometric assay for mammalian cytosolic epoxide hydrolase","volume":"106","author":"Mullin","year":"1980","journal-title":"Anal Biochem"},{"key":"10.1124\/dmd.115.063339_bib103","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0003-9861(82)90231-4","article-title":"Chalcone oxides\u2014potent selective inhibitors of cytosolic epoxide hydrolase","volume":"216","author":"Mullin","year":"1982","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.115.063339_bib104","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0048-3575(79)90067-1","article-title":"Substrate selectivity and stereochemistry of enzymatic epoxide hydration in the soluble fraction of mouse liver","volume":"11","author":"Mumby","year":"1979","journal-title":"Pestic Biochem Physiol"},{"key":"10.1124\/dmd.115.063339_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/dna.1987.6.1","article-title":"The P450 gene superfamily: recommended nomenclature","volume":"6","author":"Nebert","year":"1987","journal-title":"DNA"},{"key":"10.1124\/dmd.115.063339_bib106","first-page":"1","article-title":"Cytochrome P450 nomenclature, 2004","volume":"320","author":"Nelson","year":"2006","journal-title":"Methods Mol Biol"},{"key":"10.1124\/dmd.115.063339_bib107","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1479-7364-4-1-59","article-title":"The cytochrome p450 homepage","volume":"4","author":"Nelson","year":"2009","journal-title":"Hum Genomics"},{"key":"10.1124\/dmd.115.063339_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2004.10.001","article-title":"Epoxide hydrolases: their roles and interactions with lipid metabolism","volume":"44","author":"Newman","year":"2005","journal-title":"Prog Lipid Res"},{"key":"10.1124\/dmd.115.063339_bib109","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1073\/pnas.0437724100","article-title":"The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity","volume":"100","author":"Newman","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib110","first-page":"447","article-title":"Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis","volume":"2","author":"Norwood","year":"2010","journal-title":"Am J Transl Res"},{"key":"10.1124\/dmd.115.063339_bib111","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/00498257309151525","article-title":"Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds","volume":"3","author":"Oesch","year":"1973","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.115.063339_bib113","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/0005-2744(71)90018-0","article-title":"Solubilization, purification, and properties of a hepatic epoxide hydrase","volume":"227","author":"Oesch","year":"1971","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.115.063339_bib114","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/0006-291X(72)90807-8","article-title":"Conversion of naphthalene to trans-naphthalene dihydrodiol: evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes","volume":"46","author":"Oesch","year":"1972","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/dmd.115.063339_bib115","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0005-2744(71)90017-9","article-title":"A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide","volume":"227","author":"Oesch","year":"1971","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.115.063339_bib116","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0009-2797(73)90071-9","article-title":"Induction, activation and inhibition of epoxide hydrase: an anomalous prevention of chlorobenzene-induced hepatotoxicity by an inhibitor of epoxide hydrase","volume":"6","author":"Oesch","year":"1973","journal-title":"Chem Biol Interact"},{"key":"10.1124\/dmd.115.063339_bib117","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1021\/bi00802a005","article-title":"Hepatic epoxide hydrase. Structure-activity relationships for substrates and inhibitors","volume":"10","author":"Oesch","year":"1971","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.115.063339_bib118","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/carcin\/5.1.7","article-title":"Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities","volume":"5","author":"Oesch","year":"1984","journal-title":"Carcinogenesis"},{"key":"10.1124\/dmd.115.063339_bib119","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1194\/jlr.M022319","article-title":"Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase","volume":"53","author":"Oguro","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.115.063339_bib120","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1124\/jpet.106.103556","article-title":"Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels","volume":"318","author":"Olearczyk","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.115.063339_bib121","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1126\/science.7361100","article-title":"Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver","volume":"207","author":"Ota","year":"1980","journal-title":"Science"},{"key":"10.1124\/dmd.115.063339_bib122","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1194\/jlr.M023689","article-title":"Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles","volume":"53","author":"Paillasse","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.115.063339_bib123","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1172\/JCI58128","article-title":"Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice","volume":"122","author":"Panigrahy","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1124\/dmd.115.063339_bib124","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s10555-011-9315-y","article-title":"EET signaling in cancer","volume":"30","author":"Panigrahy","year":"2011","journal-title":"Cancer Metastasis Rev"},{"key":"10.1124\/dmd.115.063339_bib125","doi-asserted-by":"crossref","first-page":"13528","DOI":"10.1073\/pnas.1311565110","article-title":"Epoxyeicosanoids promote organ and tissue regeneration","volume":"110","author":"Panigrahy","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib126","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01805919","article-title":"Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid","volume":"8","author":"Petrakis","year":"1986","journal-title":"Breast Cancer Res Treat"},{"key":"10.1124\/dmd.115.063339_bib127","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.prostaglandins.2013.02.001","article-title":"In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor","volume":"104-105","author":"Podolin","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1124\/dmd.115.063339_bib128","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.biochi.2012.05.006","article-title":"Cholesterol-5,6-epoxides: chemistry, biochemistry, metabolic fate and cancer","volume":"95","author":"Poirot","year":"2013","journal-title":"Biochimie"},{"key":"10.1124\/dmd.115.063339_bib129","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1161\/01.HYP.0000208299.62535.58","article-title":"Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling","volume":"47","author":"Pokreisz","year":"2006","journal-title":"Hypertension"},{"key":"10.1124\/dmd.115.063339_bib130","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.lfs.2013.04.014","article-title":"Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie","volume":"92","author":"Poli","year":"2013","journal-title":"Life Sci"},{"key":"10.1124\/dmd.115.063339_bib131","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.bbalip.2014.03.010","article-title":"Isolation and characterization of Xenopus soluble epoxide hydrolase","volume":"1841","author":"Purba","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.115.063339_bib132","article-title":"Soluble epoxide hydrolase deficiency or inhibition attenuates MPTP-induced parkinsonism","author":"Qin","year":"2014","journal-title":"Mol Neurobiol"},{"key":"10.1124\/dmd.115.063339_bib133","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1021\/es103650m","article-title":"Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects","volume":"45","author":"Schebb","year":"2011","journal-title":"Environ Sci Technol"},{"key":"10.1124\/dmd.115.063339_bib134","doi-asserted-by":"crossref","first-page":"13646","DOI":"10.1073\/pnas.0605908103","article-title":"Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors","volume":"103","author":"Schmelzer","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib135","doi-asserted-by":"crossref","first-page":"9772","DOI":"10.1073\/pnas.0503279102","article-title":"Soluble epoxide hydrolase is a therapeutic target for acute inflammation","volume":"102","author":"Schmelzer","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib136","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0021-9258(17)42429-X","article-title":"Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase","volume":"261","author":"Sevanian","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.115.063339_bib137","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1073\/pnas.81.13.4198","article-title":"Cholesterol epoxide is a direct-acting mutagen","volume":"81","author":"Sevanian","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib138","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0005-2744(80)90238-7","article-title":"Lipid epoxide hydrolase in rat lung preparations","volume":"614","author":"Sevanian","year":"1980","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.115.063339_bib139","doi-asserted-by":"crossref","first-page":"H1605","DOI":"10.1152\/ajpheart.00471.2013","article-title":"Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke","volume":"305","author":"Shaik","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/dmd.115.063339_bib140","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1021\/jm201468j","article-title":"Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications","volume":"55","author":"Shen","year":"2012","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.115.063339_bib141","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.coph.2012.07.007","article-title":"Cholesterol epoxide hydrolase and cancer","volume":"12","author":"Silvente-Poirot","year":"2012","journal-title":"Curr Opin Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib142","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1073\/pnas.1221972110","article-title":"Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis","volume":"110","author":"Sirish","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib143","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1042\/bj0470284","article-title":"Studies in detoxication; the metabolism of chlorobenzene in the rabbit; isolation of dihydrodihydroxychlorobenzene, p-chlorophenylglucuronide, 4-chlorocatechol glucuronide and p-chlorophenylmercapturic acid","volume":"47","author":"Smith","year":"1950","journal-title":"Biochem J"},{"key":"10.1124\/dmd.115.063339_bib144","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1073\/pnas.0409591102","article-title":"Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor","volume":"102","author":"Smith","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib145","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0003-9861(85)90496-5","article-title":"Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs)","volume":"242","author":"Spearman","year":"1985","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.115.063339_bib146","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0163-7827(03)00049-3","article-title":"Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function","volume":"43","author":"Spector","year":"2004","journal-title":"Prog Lipid Res"},{"key":"10.1124\/dmd.115.063339_bib147","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.bbalip.2014.07.020","article-title":"Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism","volume":"1851","author":"Spector","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.115.063339_bib148","doi-asserted-by":"crossref","first-page":"C996","DOI":"10.1152\/ajpcell.00402.2006","article-title":"Action of epoxyeicosatrienoic acids on cellular function","volume":"292","author":"Spector","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/dmd.115.063339_bib149","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1124\/jpet.108.136739","article-title":"Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray","volume":"326","author":"Terashvili","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.115.063339_bib150","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1549-8719.2009.00013.x","article-title":"Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury","volume":"17","author":"Townsley","year":"2010","journal-title":"Microcirculation"},{"key":"10.1124\/dmd.115.063339_bib174","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1755-5922.2011.00282.x","article-title":"Evaluation of the effects of urotensin II and soluble epoxide hydrolase inhibitor on skin microvessel tone in healthy controls and heart failure patients","volume":"30","author":"Tran","year":"2012","journal-title":"Cardiovasc Ther"},{"key":"10.1124\/dmd.115.063339_bib151","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ejps.2010.03.018","article-title":"Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs","volume":"40","author":"Tsai","year":"2010","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/dmd.115.063339_bib152","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/j.1476-5381.2011.01641.x","article-title":"Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys","volume":"165","author":"Ulu","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib153","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/FJC.0b013e318298e460","article-title":"Anti-inflammatory effects of \u03c9-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension","volume":"62","author":"Ulu","year":"2013","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib154","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/FJC.0000000000000094","article-title":"An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension","volume":"64","author":"Ulu","year":"2014","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/dmd.115.063339_bib155","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1021\/jf102559q","article-title":"Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction","volume":"59","author":"Wagner","year":"2011","journal-title":"J Agric Food Chem"},{"key":"10.1124\/dmd.115.063339_bib156","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.prostaglandins.2011.08.001","article-title":"Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception","volume":"96","author":"Wagner","year":"2011","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1124\/dmd.115.063339_bib157","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.prostaglandins.2014.09.001","article-title":"The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling","volume":"113-115C","author":"Wagner","year":"2014","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1124\/dmd.115.063339_bib158","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jpain.2014.05.008","article-title":"Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy","volume":"15","author":"Wagner","year":"2014","journal-title":"J Pain"},{"key":"10.1124\/dmd.115.063339_bib159","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1165\/rcmb.2011-0359OC","article-title":"Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease","volume":"46","author":"Wang","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/dmd.115.063339_bib160","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1677\/joe.1.06933","article-title":"The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression","volume":"190","author":"Wang","year":"2006","journal-title":"J Endocrinol"},{"key":"10.1124\/dmd.115.063339_bib161","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0005-2760(80)90090-9","article-title":"Cholesterol \u03b1- and \u03b2-epoxides as obligatory intermediates in the hepatic microsomal metabolism of cholesterol to cholestanetriol","volume":"619","author":"Watabe","year":"1980","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.115.063339_bib162","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aca.2005.11.049","article-title":"High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleedings and LC\/MS\/MS analysis","volume":"559","author":"Watanabe","year":"2006","journal-title":"Anal Chim Acta"},{"key":"10.1124\/dmd.115.063339_bib163","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/scientificamerican0767-13","article-title":"Third-generation pesticides","volume":"217","author":"Williams","year":"1967","journal-title":"Sci Am"},{"key":"10.1124\/dmd.115.063339_bib164","series-title":"Biochemical Pharmacology and Toxicology, Volume 1: Methodological Aspects of Drug Metabolizing Enzymes","first-page":"1","article-title":"Membrane-bound and soluble-fraction epoxide hydrolase: methodological aspects","author":"Wixtrom","year":"1985"},{"key":"10.1124\/dmd.115.063339_bib165","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1165\/rcmb.2013-0440OC","article-title":"Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice","volume":"52","author":"Yang","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/dmd.115.063339_bib166","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/bj0410417","article-title":"The metabolic conversion of naphthalene to 1:2-dihydronaphthalene-1:2-diol","volume":"41","author":"Young","year":"1947","journal-title":"Biochem J"},{"key":"10.1124\/dmd.115.063339_bib167","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/01.RES.87.11.992","article-title":"Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids","volume":"87","author":"Yu","year":"2000","journal-title":"Circ Res"},{"key":"10.1124\/dmd.115.063339_bib168","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1194\/jlr.M053199","article-title":"Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity","volume":"55","author":"Zha","year":"2014","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.115.063339_bib169","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.plipres.2013.11.003","article-title":"Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer","volume":"53","author":"Zhang","year":"2014","journal-title":"Prog Lipid Res"},{"key":"10.1124\/dmd.115.063339_bib170","doi-asserted-by":"crossref","first-page":"11127","DOI":"10.1073\/pnas.1410432111","article-title":"Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib171","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1073\/pnas.1304321110","article-title":"Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis","volume":"110","author":"Zhang","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.115.063339_bib172","first-page":"1244","article-title":"Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage","volume":"15","author":"Zhao","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/dmd.115.063339_bib173","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1165\/ajrcmb.25.4.4104","article-title":"Leukotoxin-diol: a putative toxic mediator involved in acute respiratory distress syndrome","volume":"25","author":"Zheng","year":"2001","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624102899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624102899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.115.063339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T19:27:00Z","timestamp":1739906820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624102899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":173,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0090955624102899"],"URL":"https:\/\/doi.org\/10.1124\/dmd.115.063339","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The 2014 Bernard B. Brodie Award Lecture\u2014Epoxide Hydrolases: Drug Metabolism to Therapeutics for Chronic Pain","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.115.063339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}