{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:06:38Z","timestamp":1774580798266,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1124\/dmd.115.065680","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T01:23:51Z","timestamp":1441157031000},"page":"1769-1772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Polymorphic Variant P24T of UDP-Glucuronosyltransferase 1A4 and Its Unusual Consequences"],"prefix":"10.1016","volume":"43","author":[{"given":"Johanna","family":"Troberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Finel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.115.065680_bib1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1124\/dmd.107.019406","article-title":"Glucuronidation of tobacco-specific nitrosamines by UGT2B10","volume":"36","author":"Chen","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.115.065680_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0076-6879(05)00007-8","article-title":"Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases","volume":"400","author":"Court","year":"2005","journal-title":"Methods Enzymol"},{"key":"10.1124\/dmd.115.065680_bib3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3109\/00498254.2011.618954","article-title":"Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues","volume":"42","author":"Court","year":"2012","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.115.065680_bib4","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1124\/dmd.112.048157","article-title":"Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics","volume":"41","author":"Edavana","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.115.065680_bib5","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/hep.20131","article-title":"Variation of hepatic glucuronidation: novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4","volume":"39","author":"Ehmer","year":"2004","journal-title":"Hepatology"},{"key":"10.1124\/dmd.115.065680_bib6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0090-9556(25)07355-6","article-title":"Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein","volume":"24","author":"Green","year":"1996","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.115.065680_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2011.01.016","article-title":"The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy","volume":"95","author":"Gulcebi","year":"2011","journal-title":"Epilepsy Res"},{"key":"10.1124\/dmd.115.065680_bib8","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3109\/00498254.2011.563327","article-title":"N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases","volume":"41","author":"Kaivosaari","year":"2011","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.115.065680_bib9","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1124\/mol.107.037952","article-title":"Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4","volume":"72","author":"Kubota","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.115.065680_bib10","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1074\/jbc.M206136200","article-title":"Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme","volume":"278","author":"Kurkela","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.115.065680_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/FPC.0b013e328011b598","article-title":"Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6","volume":"17","author":"Kurkela","year":"2007","journal-title":"Pharmacogenet Genomics"},{"key":"10.1124\/dmd.115.065680_bib12","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1007\/s11033-012-2393-2","article-title":"Interethnic differences in UGT1A4 genetic polymorphisms between Mexican Mestizo and Spanish populations","volume":"40","author":"L\u00f3pez","year":"2013","journal-title":"Mol Biol Rep"},{"key":"10.1124\/dmd.115.065680_bib13","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/01.fpc.0000173483.13689.56","article-title":"Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily","volume":"15","author":"Mackenzie","year":"2005","journal-title":"Pharmacogenet Genomics"},{"key":"10.1124\/dmd.115.065680_bib14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat Methods"},{"key":"10.1124\/dmd.115.065680_bib15","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1021\/bi0521590","article-title":"Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization","volume":"45","author":"Polgar","year":"2006","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.115.065680_bib16","article-title":"Frequencies of UGT1A4*2 (P24T) and *3 (L48V) and their effects on serum concentrations of lamotrigine","author":"Reimers","year":"2014","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.115.065680_bib17","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1186\/bcr1539","article-title":"Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants","volume":"8","author":"Sun","year":"2006","journal-title":"Breast Cancer Res"},{"key":"10.1124\/dmd.115.065680_bib18","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev.pharmtox.40.1.581","article-title":"Human UDP-glucuronosyltransferases: metabolism, expression, and disease","volume":"40","author":"Tukey","year":"2000","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/dmd.115.065680_bib19","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1158\/0008-5472.CAN-03-3219","article-title":"Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes","volume":"64","author":"Wiener","year":"2004","journal-title":"Cancer Res"},{"key":"10.1124\/dmd.115.065680_bib20","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1124\/dmd.112.046086","article-title":"Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics","volume":"40","author":"Zhang","year":"2012","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.115.065680_bib21","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.2217\/pgs.11.105","article-title":"Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes","volume":"12","author":"Zhou","year":"2011","journal-title":"Pharmacogenomics"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624102097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624102097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.115.065680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T19:24:22Z","timestamp":1739906662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624102097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0090955624102097"],"URL":"https:\/\/doi.org\/10.1124\/dmd.115.065680","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Polymorphic Variant P24T of UDP-Glucuronosyltransferase 1A4 and Its Unusual Consequences","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.115.065680","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}