{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:06:08Z","timestamp":1792019168476,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1124\/dmd.116.070359","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:15:43Z","timestamp":1467159343000},"page":"1536-1542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Occupancy of Nociceptin\/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects"],"prefix":"10.1016","volume":"44","author":[{"given":"Eyas","family":"Raddad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E","family":"Ruegg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Tauscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Statnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J","family":"Verfaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.116.070359_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00213-002-1355-0","article-title":"Positron emission tomographic analysis of dose-dependent NAD-299 binding to 5-hydroxytryptamine-1A receptors in the human brain","volume":"167","author":"Andr\u00e9e","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/dmd.116.070359_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1124\/jpet.109.157909","article-title":"Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans","volume":"332","author":"Atack","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.116.070359_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0306-4522(03)00484-6","article-title":"[3H]-nociceptin ligand-binding and nociceptin opioid receptor mrna expression in the human brain","volume":"121","author":"Berthele","year":"2003","journal-title":"Neuroscience"},{"key":"10.1124\/dmd.116.070359_bib4","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1073\/pnas.0703472104","article-title":"[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor","volume":"104","author":"Burns","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.116.070359_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/jcbfm.1993.6","article-title":"Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography","volume":"13","author":"Carson","year":"1993","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/dmd.116.070359_bib6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/jcbfm.2009.190","article-title":"Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited","volume":"30","author":"Cunningham","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/dmd.116.070359_bib7","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neuropharm.2010.07.024","article-title":"Occupancy of human brain GABA(A) receptors by the novel \u03b15 subtype-selective benzodiazepine site inverse agonist \u03b15IA as measured using [\u00b9\u00b9C]flumazenil PET imaging","volume":"59","author":"Eng","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1124\/dmd.116.070359_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0006-8993(00)02669-X","article-title":"Autoradiographic localization of [3H]nociceptin binding sites in the rat brain","volume":"880","author":"Florin","year":"2000","journal-title":"Brain Res"},{"key":"10.1124\/dmd.116.070359_bib9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00210-006-0035-8","article-title":"Antidepressant- and anxiolytic-like effects of nociceptin\/orphanin FQ receptor ligands","volume":"372","author":"Gavioli","year":"2006","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/dmd.116.070359_bib10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pharmthera.2009.03.002","article-title":"Target site occupancy: emerging generalizations from clinical and preclinical studies","volume":"122","author":"Grimwood","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1124\/dmd.116.070359_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2012.11.053","article-title":"Evaluation of [\u00b9\u2078F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human","volume":"68","author":"Hostetler","year":"2013","journal-title":"Neuroimage"},{"key":"10.1124\/dmd.116.070359_bib12","first-page":"755","article-title":"An introduction to PET and SPECT neuroreceptor quantification models","volume":"42","author":"Ichise","year":"2001","journal-title":"J Nucl Med"},{"key":"10.1124\/dmd.116.070359_bib13","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/sj.jcbfm.9600493","article-title":"Consensus nomenclature for in vivo imaging of reversibly binding radioligands","volume":"27","author":"Innis","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/dmd.116.070359_bib14","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.2967\/jnumed.111.091181","article-title":"Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin\/orphanin FQ peptide receptors","volume":"52","author":"Kimura","year":"2011","journal-title":"J Nucl Med"},{"key":"10.1124\/dmd.116.070359_bib15","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nrd2572","article-title":"The nociceptin\/orphanin FQ receptor: a target with broad therapeutic potential","volume":"7","author":"Lambert","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/dmd.116.070359_bib16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/jcbfm.1995.17","article-title":"Benzodiazepine receptor quantification in vivo in humans using [11C]flumazenil and PET: application of the steady-state principle","volume":"15","author":"Lassen","year":"1995","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/dmd.116.070359_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroimage.2013.10.068","article-title":"Retest imaging of [11C]NOP-1A binding to nociceptin\/orphanin FQ peptide (NOP) receptors in the brain of healthy humans","volume":"87","author":"Lohith","year":"2014","journal-title":"Neuroimage"},{"key":"10.1124\/dmd.116.070359_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2967\/jnumed.111.097162","article-title":"Brain and whole-body imaging of nociceptin\/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A","volume":"53","author":"Lohith","year":"2012","journal-title":"J Nucl Med"},{"key":"10.1124\/dmd.116.070359_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.112.199794","article-title":"Translation of central nervous system occupancy from animal models: application of pharmacokinetic\/pharmacodynamic modeling","volume":"347","author":"Melhem","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.116.070359_bib20","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/377532a0","article-title":"Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor","volume":"377","author":"Meunier","year":"1995","journal-title":"Nature"},{"key":"10.1124\/dmd.116.070359_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/187152710790966713","article-title":"The nociceptin\/orphanin FQ system as a target for treating alcoholism","volume":"9","author":"Murphy","year":"2010","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1124\/dmd.116.070359_bib22","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/(SICI)1096-9861(19991004)412:4<563::AID-CNE2>3.0.CO;2-Z","article-title":"Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding","volume":"412","author":"Neal","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1124\/dmd.116.070359_bib23","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1021\/jm201629q","article-title":"Development of LC-MS\/MS-based receptor occupancy tracers and positron emission tomography radioligands for the nociceptin\/orphanin FQ (NOP) receptor","volume":"55","author":"Pedregal","year":"2012","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.116.070359_bib24","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1021\/jm101487v","article-title":"Synthesis and evaluation of radioligands for imaging brain nociceptin\/orphanin FQ peptide (NOP) receptors with positron emission tomography","volume":"54","author":"Pike","year":"2011","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.116.070359_bib25","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/npp.2015.348","article-title":"A selective nociceptin receptor antagonist to treat depression: evidence from preclinical and clinical studies","volume":"41","author":"Post","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/dmd.116.070359_bib26","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.270.5237.792","article-title":"Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor","volume":"270","author":"Reinscheid","year":"1995","journal-title":"Science"},{"key":"10.1124\/dmd.116.070359_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pscychresns.2006.01.011","article-title":"An automated method for the extraction of regional data from PET images","volume":"147","author":"Rusjan","year":"2006","journal-title":"Psychiatry Res"},{"key":"10.1124\/dmd.116.070359_bib28","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1124\/jpet.106.116764","article-title":"Pharmacological characterization of the nociceptin\/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies","volume":"321","author":"Spagnolo","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.116.070359_bib29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1124\/jpet.115.228221","article-title":"A novel nociceptin receptor antagonist LY2940094 inhibits excessive feeding behavior in rodents: a possible mechanism for the treatment of binge eating disorder","volume":"356","author":"Statnick","year":"2016","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.116.070359_bib30","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1021\/jm500117r","article-title":"Discovery of a novel series of orally active nociceptin\/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7\u2032-thieno[2,3-c]pyran) scaffold","volume":"57","author":"Toledo","year":"2014","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.116.070359_bib31","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pharmthera.2013.10.011","article-title":"The biology of Nociceptin\/Orphanin FQ (N\/OFQ) related to obesity, stress, anxiety, mood, and drug dependence","volume":"141","author":"Witkin","year":"2014","journal-title":"Pharmacol Ther"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624101171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624101171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.116.070359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T14:21:34Z","timestamp":1739888494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624101171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0090955624101171"],"URL":"https:\/\/doi.org\/10.1124\/dmd.116.070359","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Occupancy of Nociceptin\/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.116.070359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}