{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:30:06Z","timestamp":1790731806872,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1124\/dmd.116.073791","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T03:00:33Z","timestamp":1480647633000},"page":"160-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Management of Rodent Populations by Anticoagulant Rodenticides: Toward Third-Generation Anticoagulant Rodenticides"],"prefix":"10.1016","volume":"45","author":[{"given":"Marl\u00e8ne","family":"Damin-Pernik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Espana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Fourel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Caruel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Benoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Lattard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.116.073791_bib1","series-title":"Study on risk mitigation measures for anticoagulant rodenticides as biocidal products final report","author":"Berny","year":"2014"},{"key":"10.1124\/dmd.116.073791_bib2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/188517a0","article-title":"Rattus norvegicus Berkenhout to anticoagulant poisons","volume":"188","author":"Boyle","year":"1960","journal-title":"Nature"},{"key":"10.1124\/dmd.116.073791_bib3","series-title":"Rodent Pests and Their Control","author":"Buckle","year":"2015"},{"key":"10.1124\/dmd.116.073791_bib4","unstructured":"Caruel H, Espana B, Besse S, Lattard V, and Benoit E (2015) inventors, Liphatech, assignee. Composition comprising difethialone, rodenticide bait and method for controlling target rodent pests. European Patent Office WO2015189321 (A1). 2015 Dec 17."},{"key":"10.1124\/dmd.116.073791_bib5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00244-012-9771-6","article-title":"High exposure rates of anticoagulant rodenticides in predatory bird species in intensively managed landscapes in Denmark","volume":"63","author":"Christensen","year":"2012","journal-title":"Arch Environ Contam Toxicol"},{"key":"10.1124\/dmd.116.073791_bib6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.forsciint.2011.08.003","article-title":"Measurement and analysis of diastereomer ratios for forensic characterization of brodifacoum","volume":"214","author":"Cort","year":"2012","journal-title":"Forensic Sci Int"},{"key":"10.1124\/dmd.116.073791_bib7","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1124\/dmd.116.071688","article-title":"Development of an ecofriendly anticoagulant rodenticide based on the stereochemistry of difenacoum","volume":"44","author":"Damin-Pernik","year":"2016","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.116.073791_bib8","article-title":"Mice and spreading despite such poisons as warfarin","volume":"3746","author":"Dodsworth","year":"1961","journal-title":"Munic Eng"},{"key":"10.1124\/dmd.116.073791_bib9","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.scitotenv.2011.03.006","article-title":"Mustela erminea Mustela nivalis from Denmark","volume":"409","author":"Elmeros","year":"2011","journal-title":"Sci Total Environ"},{"key":"10.1124\/dmd.116.073791_bib10","series-title":"Inclusion of Active Substances in Annex I or IA to Directive 98\/8\/EC. Difethialone. Product-type 14 (rodenticides)","year":"2007"},{"key":"10.1124\/dmd.116.073791_bib11","series-title":"Inclusion of Active Substances in Annex I or IA to Directive 98\/8\/EC. Flocoumafen. Product-type 14 (rodenticides)","year":"2009"},{"key":"10.1124\/dmd.116.073791_bib12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.7589\/0090-3558-40.4.688","article-title":"Evidence of secondary poisoning of free-ranging riparian mustelids by anticoagulant rodenticides in France: implications for conservation of European mink (Mustela lutreola)","volume":"40","author":"Fournier-Chambrillon","year":"2004","journal-title":"J Wildl Dis"},{"key":"10.1124\/dmd.116.073791_bib13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(88)90567-3","article-title":"The molecular basis of blood coagulation","volume":"53","author":"Furie","year":"1988","journal-title":"Cell"},{"key":"10.1124\/dmd.116.073791_bib14","article-title":"Vulpes vulpes)","volume":"10","author":"Geduhn","year":"2015","journal-title":"PLoS One"},{"key":"10.1124\/dmd.116.073791_bib15","unstructured":"Hadler MR, Buckle A (1992) Forty five years of anticoagulant rodenticides - past, present and future trends. Proceedings of the Vert Pest Conference, vol 15, pp 149\u2013155."},{"key":"10.1124\/dmd.116.073791_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.abb.2011.08.010","article-title":"Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants","volume":"515","author":"Hodroge","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.116.073791_bib17","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1111\/jth.12019","article-title":"VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity","volume":"10","author":"Hodroge","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1124\/dmd.116.073791_bib18","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3109\/00498258809042269","article-title":"Elimination and accumulation of the rodenticide flocoumafen in rats following repeated oral administration","volume":"18","author":"Huckle","year":"1988","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.116.073791_bib19","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1007\/s10646-013-1074-9","article-title":"Monitoring agricultural rodenticide use and secondary exposure of raptors in Scotland","volume":"22","author":"Hughes","year":"2013","journal-title":"Ecotoxicology"},{"key":"10.1124\/dmd.116.073791_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0021-9673(01)82165-8","article-title":"Determination of diastereoisomers of bromadiolone, an anticoagulant rodenticide, in animal tissues by high-performance liquid chromatography","volume":"435","author":"Hunter","year":"1988","journal-title":"J Chromatogr A"},{"key":"10.1124\/dmd.116.073791_bib21","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1126\/science.176.4041.1343","article-title":"Resistance of wild Norway rats in North Carolina to warfarin rodenticide","volume":"176","author":"Jackson","year":"1972","journal-title":"Science"},{"key":"10.1124\/dmd.116.073791_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0378-4347(93)80057-B","article-title":"Simple and rapid method for the determination of the diastereomers of difenacoum in blood and liver using high-performance liquid chromatography with fluorescence detection","volume":"620","author":"Kelly","year":"1993","journal-title":"J Chromatogr A"},{"key":"10.1124\/dmd.116.073791_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.scitotenv.2013.01.100","article-title":"The occurrence of second generation anticoagulant rodenticides in non-target raptor species in Norway","volume":"450\u2013451","author":"Langford","year":"2013","journal-title":"Sci Total Environ"},{"key":"10.1124\/dmd.116.073791_bib24","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature02254","article-title":"Identification of the gene for vitamin K epoxide reductase","volume":"427","author":"Li","year":"2004","journal-title":"Nature"},{"key":"10.1124\/dmd.116.073791_bib25","doi-asserted-by":"crossref","first-page":"8433","DOI":"10.1021\/es501740n","article-title":"Adverse outcome pathway and risks of anticoagulant rodenticides to predatory wildlife","volume":"48","author":"Rattner","year":"2014","journal-title":"Environ Sci Technol"},{"key":"10.1124\/dmd.116.073791_bib26","series-title":"RRAC Guidelines on Anticoagulant Rodenticide Resistance Management","year":"2015"},{"key":"10.1124\/dmd.116.073791_bib27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature02214","article-title":"Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2","volume":"427","author":"Rost","year":"2004","journal-title":"Nature"},{"key":"10.1124\/dmd.116.073791_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2156-10-4","article-title":"Novel mutations in the VKORC1 gene of wild rats and mice\u2014a response to 50 years of selection pressure by warfarin?","volume":"10","author":"Rost","year":"2009","journal-title":"BMC Genet"},{"key":"10.1124\/dmd.116.073791_bib29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.scitotenv.2014.03.094","article-title":"Assessment of anticoagulant rodenticide exposure in six raptor species from the Canary Islands (Spain)","volume":"485\u2013486","author":"Ruiz-Su\u00e1rez","year":"2014","journal-title":"Sci Total Environ"},{"key":"10.1124\/dmd.116.073791_bib30","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.envres.2010.07.009","article-title":"Determination of bromadiolone residues in fox faeces by LC\/ESI-MS in relationship with toxicological data and clinical signs after repeated exposure","volume":"110","author":"Sage","year":"2010","journal-title":"Environ Res"},{"key":"10.1124\/dmd.116.073791_bib31","first-page":"39","article-title":"Resistance to warfarin in the roof rat in Sydney, NSW","volume":"9","author":"Saunders","year":"1978","journal-title":"Search"},{"key":"10.1124\/dmd.116.073791_bib32","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1007\/s10646-015-1429-5","article-title":"Anticoagulant rodenticides in urban bobcats: exposure, risk factors and potential effects based on a 16-year study","volume":"24","author":"Serieys","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1124\/dmd.116.073791_bib33","first-page":"49","article-title":"Anticoagulant resistance in house mice in Toronto, Canada","volume":"32","author":"Siddiq","year":"1982","journal-title":"Environ Health Rev"},{"key":"10.1124\/dmd.116.073791_bib34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.bi.54.070185.002331","article-title":"Vitamin K-dependent carboxylase","volume":"54","author":"Suttie","year":"1985","journal-title":"Annu Rev Biochem"},{"key":"10.1124\/dmd.116.073791_bib35","unstructured":"Swaine H (1985) inventor, Imperial Chemical Industries PLC, assignee. Rodenticides. European Patent Office EP0147052 B1. 1985 Sep 9."},{"key":"10.1124\/dmd.116.073791_bib36","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.envint.2011.03.010","article-title":"Second generation anticoagulant rodenticides in predatory birds: probabilistic characterisation of toxic liver concentrations and implications for predatory bird populations in Canada","volume":"37","author":"Thomas","year":"2011","journal-title":"Environ Int"},{"key":"10.1124\/dmd.116.073791_bib37","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1021\/ja01867a066","article-title":"Hydro, oxido and other derivatives of vitamin K1 and related compounds","volume":"62","author":"Tishler","year":"1940","journal-title":"J Am Chem Soc"},{"key":"10.1124\/dmd.116.073791_bib38","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2885.2008.00979.x","article-title":"Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration","volume":"31","author":"Vandenbroucke","year":"2008","journal-title":"J Vet Pharmacol Ther"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624053224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624053224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.116.073791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:21:13Z","timestamp":1739902873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624053224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0090955624053224"],"URL":"https:\/\/doi.org\/10.1124\/dmd.116.073791","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of Rodent Populations by Anticoagulant Rodenticides: Toward Third-Generation Anticoagulant Rodenticides","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.116.073791","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}