{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:13:50Z","timestamp":1790039630699,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1124\/dmd.117.075697","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:30:21Z","timestamp":1493339421000},"page":"807-816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis"],"prefix":"10.1016","volume":"45","author":[{"given":"Joan P.","family":"Graves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artiom","family":"Gruzdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alyce","family":"Bradbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"DeGraff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Edin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl C.","family":"Zeldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.117.075697_bib1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/01.RES.78.3.415","article-title":"Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors","volume":"78","author":"Campbell","year":"1996","journal-title":"Circ Res"},{"key":"10.1124\/dmd.117.075697_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-2275(20)32049-6","article-title":"Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase","volume":"41","author":"Capdevila","year":"2000","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.117.075697_bib3","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1074\/jbc.M113.508416","article-title":"The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt","volume":"289","author":"Capdevila","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.117.075697_bib4","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0022-3565(25)24028-9","article-title":"Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9","volume":"271","author":"Daikh","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.117.075697_bib5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1124\/jpet.104.067819","article-title":"CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products","volume":"310","author":"DeLozier","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.117.075697_bib6","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.amjhyper.2005.04.019","article-title":"The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension","volume":"18","author":"Dreisbach","year":"2005","journal-title":"Am J Hypertens"},{"key":"10.1124\/dmd.117.075697_bib7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/002215540405200403","article-title":"Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues","volume":"52","author":"Enayetallah","year":"2004","journal-title":"J Histochem Cytochem"},{"key":"10.1124\/dmd.117.075697_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00008571-199412000-00001","article-title":"Biochemistry and molecular biology of the human CYP2C subfamily","volume":"4","author":"Goldstein","year":"1994","journal-title":"Pharmacogenetics"},{"key":"10.1124\/dmd.117.075697_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1214\/aoms\/1177729885","article-title":"Sample criteria for testing outlying observations","volume":"21","author":"Grubbs","year":"1950","journal-title":"Ann Math Stat"},{"key":"10.1124\/dmd.117.075697_bib10","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/0024-3205(92)90136-D","article-title":"Human cytochrome P-450 enzymes","volume":"50","author":"Guengerich","year":"1992","journal-title":"Life Sci"},{"key":"10.1124\/dmd.117.075697_bib11","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1101\/gr.6.10.986","article-title":"Real time quantitative PCR","volume":"6","author":"Heid","year":"1996","journal-title":"Genome Res"},{"key":"10.1124\/dmd.117.075697_bib12","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1124\/mol.65.6.1397","article-title":"The constitutive active\/androstane receptor regulates phenytoin induction of Cyp2c29","volume":"65","author":"Jackson","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.117.075697_bib13","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1124\/dmd.106.012005","article-title":"Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor","volume":"34","author":"Jackson","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.117.075697_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/10408449209089881","article-title":"Small intestinal cytochromes P450","volume":"21","author":"Kaminsky","year":"1992","journal-title":"Crit Rev Toxicol"},{"key":"10.1124\/dmd.117.075697_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01213011-200501000-00002","article-title":"Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension","volume":"15","author":"King","year":"2005","journal-title":"Pharmacogenet Genomics"},{"key":"10.1124\/dmd.117.075697_bib16","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1124\/dmd.110.032334","article-title":"The nuclear receptors constitutive active\/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver","volume":"38","author":"Konno","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.117.075697_bib17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00041433-200206000-00007","article-title":"Cytochrome P450 pathways of arachidonic acid metabolism","volume":"13","author":"Kroetz","year":"2002","journal-title":"Curr Opin Lipidol"},{"key":"10.1124\/dmd.117.075697_bib18","doi-asserted-by":"crossref","first-page":"H491","DOI":"10.1152\/ajpheart.00927.2005","article-title":"Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition","volume":"290","author":"Larsen","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/dmd.117.075697_bib19","first-page":"189","article-title":"A major role for cytochrome P450TB (CYP2C subfamily) in the actions of non-steroidal antiinflammatory drugs","volume":"19","author":"Leemann","year":"1993","journal-title":"Drugs Exp Clin Res"},{"key":"10.1124\/dmd.117.075697_bib20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1124\/dmd.117.075697_bib21","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1124\/dmd.107.019349","article-title":"Generation of mice transgenic for human CYP2C18 and CYP2C19: characterization of the sexually dimorphic gene and enzyme expression","volume":"36","author":"L\u00f6fgren","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.117.075697_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/abbi.1998.0806","article-title":"Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid","volume":"357","author":"Luo","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.117.075697_bib23","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(02)11203-7","article-title":"Clinical importance of the cytochromes P450","volume":"360","author":"Nebert","year":"2002","journal-title":"Lancet"},{"key":"10.1124\/dmd.117.075697_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-199602000-00002","article-title":"P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature","volume":"6","author":"Nelson","year":"1996","journal-title":"Pharmacogenetics"},{"key":"10.1124\/dmd.117.075697_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-200401000-00001","article-title":"Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants","volume":"14","author":"Nelson","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1124\/dmd.117.075697_bib26","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.285.5431.1276","article-title":"Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids","volume":"285","author":"Node","year":"1999","journal-title":"Science"},{"key":"10.1124\/dmd.117.075697_bib27","doi-asserted-by":"crossref","first-page":"15983","DOI":"10.1074\/jbc.M100439200","article-title":"Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids","volume":"276","author":"Node","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.117.075697_bib28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1124\/dmd.105.008672","article-title":"The human intestinal cytochrome P450 \u201cpie\u201d","volume":"34","author":"Paine","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.117.075697_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1472-6750-3-18","article-title":"Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions","volume":"3","author":"Ponchel","year":"2003","journal-title":"BMC Biotechnol"},{"key":"10.1124\/dmd.117.075697_bib30","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1124\/mol.112.080036","article-title":"Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines","volume":"82","author":"Scheer","year":"2012","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.117.075697_bib31","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1161\/01.RES.0000139436.89654.c8","article-title":"Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42\/p44 MAPK pathway","volume":"95","author":"Seubert","year":"2004","journal-title":"Circ Res"},{"key":"10.1124\/dmd.117.075697_bib32","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/01.RES.0000237390.92932.37","article-title":"Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function","volume":"99","author":"Seubert","year":"2006","journal-title":"Circ Res"},{"key":"10.1124\/dmd.117.075697_bib33","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1365-2710.1999.00246.x","article-title":"Gender-related differences in pharmacokinetics and their clinical significance","volume":"24","author":"Tanaka","year":"1999","journal-title":"J Clin Pharm Ther"},{"key":"10.1124\/dmd.117.075697_bib34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0026-895X(24)12063-9","article-title":"CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract","volume":"58","author":"Tsao","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.117.075697_bib35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10528-015-9696-7","article-title":"Gender-specific effect of CYP2C8*3 on the risk of essential hypertension in Bulgarian Patients","volume":"53","author":"Tzveova","year":"2015","journal-title":"Biochem Genet"},{"key":"10.1124\/dmd.117.075697_bib36","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/0006-291X(91)91680-B","article-title":"Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9","volume":"175","author":"Veronese","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/dmd.117.075697_bib37","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1124\/mol.65.5.1148","article-title":"Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities","volume":"65","author":"Wang","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.117.075697_bib38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1124\/jpet.105.083477","article-title":"Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase\/Akt signaling pathways","volume":"314","author":"Wang","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.117.075697_bib39","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1042\/bj2810577","article-title":"Phenobarbital induction of cytochrome P-450 gene expression","volume":"281","author":"Waxman","year":"1992","journal-title":"Biochem J"},{"key":"10.1124\/dmd.117.075697_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1124\/mol.109.056705","article-title":"Sex differences in the expression of hepatic drug metabolizing enzymes","volume":"76","author":"Waxman","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.117.075697_bib41","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1006\/abbi.1995.1438","article-title":"Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform","volume":"322","author":"Zeldin","year":"1995","journal-title":"Arch Biochem Biophys"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624053911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624053911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.117.075697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:30:04Z","timestamp":1739903404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624053911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0090955624053911"],"URL":"https:\/\/doi.org\/10.1124\/dmd.117.075697","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.117.075697","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government work not protected by U.S. copyright","name":"copyright","label":"Copyright"}]}}