{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:40:17Z","timestamp":1761946817157,"version":"3.37.3"},"reference-count":27,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1124\/dmd.118.083014","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T16:55:31Z","timestamp":1534438531000},"page":"1462-1465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation"],"prefix":"10.1016","volume":"46","author":[{"given":"Albert","family":"Braeuning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinand","family":"Kollotzek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Knorpp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus F.","family":"Templin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.118.083014_bib1","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1038\/sj.onc.1204982","article-title":"Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors","volume":"20","author":"Aydinlik","year":"2001","journal-title":"Oncogene"},{"key":"10.1124\/dmd.118.083014_bib2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1186\/1471-2407-14-766","article-title":"Chemically induced mouse liver tumors are resistant to treatment with atorvastatin","volume":"14","author":"Braeuning","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1124\/dmd.118.083014_bib3","doi-asserted-by":"crossref","unstructured":"Braeuning A, Heubach Y, Knorpp T, Kowalik MA, Templin M, Columbano A, Schwarz M (2011) Gender-specific interplay of signaling through \u03b2-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation. Toxicol Sci 123(1):113\u2013122.","DOI":"10.1093\/toxsci\/kfr166"},{"key":"10.1124\/dmd.118.083014_bib4","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1515\/bc.2010.115","article-title":"Zonation of heme synthesis enzymes in mouse liver and their regulation by \u03b2-catenin and Ha-ras","volume":"391","author":"Braeuning","year":"2010","journal-title":"Biol Chem"},{"key":"10.1124\/dmd.118.083014_bib5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00418-010-0747-1","article-title":"Phenotype and growth behavior of residual \u03b2-catenin-positive hepatocytes in livers of \u03b2-catenin-deficient mice","volume":"134","author":"Braeuning","year":"2010","journal-title":"Histochem Cell Biol"},{"key":"10.1124\/dmd.118.083014_bib6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3109\/10408444.2013.835786","article-title":"Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: a case study with phenobarbital as a model constitutive androstane receptor (CAR) activator","volume":"44","author":"Elcombe","year":"2014","journal-title":"Crit Rev Toxicol"},{"key":"10.1124\/dmd.118.083014_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/hep.21082","article-title":"Zonal gene expression in murine liver: lessons from tumors","volume":"43","author":"Hailfinger","year":"2006","journal-title":"Hepatology"},{"key":"10.1124\/dmd.118.083014_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/187569209788654005","article-title":"Activation of CAR and PXR by dietary, environmental and occupational chemicals alters drug metabolism, intermediary metabolism, and cell proliferation","volume":"7","author":"Hernandez","year":"2009","journal-title":"Curr Pharmacogenomics Person Med"},{"key":"10.1124\/dmd.118.083014_bib9","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/sj.onc.1208265","article-title":"B-raf and Ha-ras mutations in chemically induced mouse liver tumors","volume":"24","author":"Jaworski","year":"2005","journal-title":"Oncogene"},{"key":"10.1124\/dmd.118.083014_bib10","doi-asserted-by":"crossref","unstructured":"Jaworski M, Ittrich C, Hailfinger S, Bonin M, Buchmann A, Schwarz M, K\u00f6hle C (2007) Global gene expression in Ha-ras and B-raf mutated mouse liver tumors. Int J Cancer 121(6):1382\u20131385.","DOI":"10.1002\/ijc.22801"},{"key":"10.1124\/dmd.118.083014_bib11","doi-asserted-by":"crossref","unstructured":"Knebel C, Neeb J, Zahn E, Schmidt F, Carazo A, Holas O, Pavek P, P\u00fcschel GP, Zanger UM, S\u00fcssmuth R et al. (2018) Unexpected effects of propiconazole, tebuconazole, and their mixture on the receptors CAR and PXR in human liver cells. Toxicol Sci 163(1):170\u2013181.","DOI":"10.1093\/toxsci\/kfy026"},{"key":"10.1124\/dmd.118.083014_bib12","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s00204-015-1522-9","article-title":"Regulation of gene expression by CAR: an update","volume":"89","author":"Kobayashi","year":"2015","journal-title":"Arch Toxicol"},{"key":"10.1124\/dmd.118.083014_bib13","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1124\/mol.107.034538","article-title":"Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active\/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes","volume":"71","author":"Koike","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.118.083014_bib14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/019262330002800201","article-title":"Paradoxical effects of phenobarbital on mouse hepatocarcinogenesis","volume":"28","author":"Lee","year":"2000","journal-title":"Toxicol Pathol"},{"key":"10.1124\/dmd.118.083014_bib15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/carcin\/bgh298","article-title":"A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors","volume":"26","author":"Loeppen","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1124\/dmd.118.083014_bib16","first-page":"5087","article-title":"Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice","volume":"60","author":"Moennikes","year":"2000","journal-title":"Cancer Res"},{"key":"10.1124\/dmd.118.083014_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1515\/dmdi-2013-0009","article-title":"An update on the constitutive androstane receptor (CAR)","volume":"28","author":"Moln\u00e1r","year":"2013","journal-title":"Drug Metabol Drug Interact"},{"key":"10.1124\/dmd.118.083014_bib18","doi-asserted-by":"crossref","first-page":"ra31","DOI":"10.1126\/scisignal.2003705","article-title":"Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling","volume":"6","author":"Mutoh","year":"2013","journal-title":"Sci Signal"},{"key":"10.1124\/dmd.118.083014_bib19","doi-asserted-by":"crossref","first-page":"e002","DOI":"10.1621\/nrs.13002","article-title":"Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium","volume":"13","author":"Oshida","year":"2015","journal-title":"Nucl Recept Signal"},{"key":"10.1124\/dmd.118.083014_bib20","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/dmd.118.083014_bib21","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1002\/pmic.200800159","article-title":"Novel functional profiling approach combining reverse phase protein microarrays and human 3-D ex vivo tissue cultures: expression of apoptosis-related proteins in human colon cancer","volume":"9","author":"Pirnia","year":"2009","journal-title":"Proteomics"},{"key":"10.1124\/dmd.118.083014_bib22","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1021\/pr9002933","article-title":"Comparative transcriptome and proteome analysis of Ha-ras and B-raf mutated mouse liver tumors","volume":"8","author":"Rignall","year":"2009","journal-title":"J Proteome Res"},{"key":"10.1124\/dmd.118.083014_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1385\/MB:31:2:151","article-title":"The ERK cascade: a prototype of MAPK signaling","volume":"31","author":"Rubinfeld","year":"2005","journal-title":"Mol Biotechnol"},{"key":"10.1124\/dmd.118.083014_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0076-6879(06)11009-5","article-title":"TM4 microarray software suite","volume":"411","author":"Saeed","year":"2006","journal-title":"Methods Enzymol"},{"key":"10.1124\/dmd.118.083014_bib25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1586\/17512433.2014.910111","article-title":"Understanding and preventing drug-drug and drug-gene interactions","volume":"7","author":"Tannenbaum","year":"2014","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1124\/dmd.118.083014_bib26","doi-asserted-by":"crossref","unstructured":"Unterberger EB, Eichner J, Wrzodek C, Lempi\u00e4inen H, Luisier R, Terranova R, Metzger U, Plummer S, Knorpp T, Braeuning A et al. (2014) Ha-ras and \u03b2-catenin oncoproteins orchestrate metabolic programs in mouse liver tumors. Int J Cancer 135(7):1574\u20131585.","DOI":"10.1002\/ijc.28798"},{"key":"10.1124\/dmd.118.083014_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tem.2009.03.003","article-title":"PXR and CAR in energy metabolism","volume":"20","author":"Wada","year":"2009","journal-title":"Trends Endocrinol Metab"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624056289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624056289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.118.083014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:38:46Z","timestamp":1739903926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624056289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0090955624056289"],"URL":"https:\/\/doi.org\/10.1124\/dmd.118.083014","relation":{},"ISSN":["0090-9556"],"issn-type":[{"type":"print","value":"0090-9556"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.118.083014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}