{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T11:46:03Z","timestamp":1769946363485,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1124\/dmd.118.083808","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T21:29:17Z","timestamp":1544045357000},"page":"80-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Serotonin Receptors of 5-HT2 Type in the Hypothalamic Arcuate Nuclei Positively Regulate Liver Cytochrome P450 via Stimulation of the Growth Hormone\u2013Releasing Hormone\/Growth Hormone Hormonal Pathway"],"prefix":"10.1016","volume":"47","author":[{"given":"Ewa","family":"Bromek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rysz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Haduch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u0142adys\u0142awa A.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.118.083808_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/A:1022579327647","article-title":"Hypothalamic and hypophyseal regulation of growth hormone secretion","volume":"18","author":"Bluet-Pajot","year":"1998","journal-title":"Cell Mol Neurobiol"},{"key":"10.1124\/dmd.118.083808_bib2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1124\/dmd.117.079632","article-title":"Activation of 5-HT1A receptors in the hypothalamic paraventricular nuclei negatively regulates cytochrome P450 expression and activity in rat liver","volume":"46","author":"Bromek","year":"2018","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.118.083808_bib3","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.bcp.2013.09.006","article-title":"Involvement of the paraventricular (PVN) and arcuate (ARC) nuclei of the hypothalamus in the central noradrenergic regulation of liver cytochrome P450","volume":"86","author":"Bromek","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib39","unstructured":"Commission of the European Communities (1986) Council Directive 86\/609\/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. OJ L 358, 18.12.1986, p. 0001-0028."},{"key":"10.1124\/dmd.118.083808_bib4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pbb.2010.05.027","article-title":"Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilization","volume":"97","author":"Currie","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/dmd.118.083808_bib5","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1211\/0022357001777685","article-title":"Different effects of amitriptyline and imipramine on the pharmacokinetics and metabolism of perazine in rats","volume":"52","author":"Daniel","year":"2000","journal-title":"J Pharm Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbr.2011.08.044","article-title":"5-HT2A receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze","volume":"226","author":"de Paula","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1124\/dmd.118.083808_bib7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3109\/03602532.2010.484462","article-title":"Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids","volume":"42","author":"Dvorak","year":"2010","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.118.083808_bib8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0091-3057(01)00717-1","article-title":"Activation of 5-HT1B receptors in the nucleus accumbens reduces self-administration of amphetamine on a progressive ratio schedule","volume":"71","author":"Fletcher","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/dmd.118.083808_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s002130050876","article-title":"Activation of 5-HT1B receptors in the nucleus accumbens reduces amphetamine-induced enhancement of responding for conditioned reward","volume":"142","author":"Fletcher","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/dmd.118.083808_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/00498250110102674","article-title":"Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man","volume":"32","author":"Gibson","year":"2002","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.118.083808_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(87)90065-6","article-title":"Forebrain and brainstem afferents to the arcuate nucleus in the rat: potential pathways for the modulation of hypophyseal secretions","volume":"75","author":"Gruber","year":"1987","journal-title":"Neurosci Lett"},{"key":"10.1124\/dmd.118.083808_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.euroneuro.2005.08.004","article-title":"The effect of tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs) and newer antidepressant drugs on the activity and level of rat CYP3A","volume":"16","author":"Haduch","year":"2006","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1124\/dmd.118.083808_bib13","first-page":"957","article-title":"Effect of selected antidepressant drugs on cytochrome P450 2B (CYP2B) in rat liver. An in vitro and in vivo study","volume":"60","author":"Haduch","year":"2008","journal-title":"Pharmacol Rep"},{"key":"10.1124\/dmd.118.083808_bib14","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1100\/tsw.2010.180","article-title":"Therapeutic potential of 5-HT2C receptor ligands","volume":"10","author":"Jensen","year":"2010","journal-title":"Sci World J"},{"key":"10.1124\/dmd.118.083808_bib15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0306-4530(95)00043-7","article-title":"Inhibition of GH in maternal separation may be mediated through altered serotonergic activity at 5-HT2A and 5-HT2C receptors","volume":"21","author":"Katz","year":"1996","journal-title":"Psychoneuroendocrinology"},{"key":"10.1124\/dmd.118.083808_bib16","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.bcp.2007.12.017","article-title":"Relative contribution of rat cytochrome P450 isoforms to the metabolism of caffeine: the pathway and concentration dependence","volume":"75","author":"Kot","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejphar.2015.01.014","article-title":"The role of the dorsal noradrenergic pathway of the brain (locus coeruleus) in the regulation of liver cytochrome P450 activity","volume":"751","author":"Kot","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0006-8993(97)00172-8","article-title":"Antinociception induced by opioid or 5-HT agonists microinjected into the anterior pretectal nucleus of the rat","volume":"757","author":"Mamede Rosa","year":"1997","journal-title":"Brain Res"},{"key":"10.1124\/dmd.118.083808_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.coph.2011.02.007","article-title":"The role of serotonin receptors in the action of atypical antipsychotic drugs","volume":"11","author":"Meltzer","year":"2011","journal-title":"Curr Opin Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib20","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1210\/endo-119-3-1089","article-title":"Involvement of growth hormone (GH)-releasing factor in GH secretion induced by serotoninergic mechanisms in conscious rats","volume":"119","author":"Murakami","year":"1986","journal-title":"Endocrinology"},{"key":"10.1124\/dmd.118.083808_bib21","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1185\/03007995.2013.794776","article-title":"Lorcaserin: a novel serotonin 2C agonist for the treatment of obesity","volume":"29","author":"Nigro","year":"2013","journal-title":"Curr Med Res Opin"},{"key":"10.1124\/dmd.118.083808_bib22","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"key":"10.1124\/dmd.118.083808_bib23","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1517\/13543784.2012.719872","article-title":"5-HT2 ligands in the treatment of anxiety and depression","volume":"21","author":"Quesseveur","year":"2012","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1124\/dmd.118.083808_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-642-25758-2_6","article-title":"5-HT2C agonists as therapeutics for the treatment of schizophrenia","volume":"213","author":"Rosenzweig-Lipson","year":"2012","journal-title":"Handb Exp Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bcp.2015.11.014","article-title":"Activation of brain serotonergic system by repeated intracerebral administration of 5-hydroxytryptophan (5-HTP) decreases the expression and activity of liver cytochrome P450","volume":"99","author":"Rysz","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bcp.2016.04.017","article-title":"The reverse role of the hypothalamic paraventricular (PVN) and arcuate (ARC) nuclei in the central serotonergic regulation of the liver cytochrome P450 isoform CYP2C11","volume":"112","author":"Rysz","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib27","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1124\/dmd.115.064980","article-title":"Damage to the brain serotonergic system increases the expression of liver cytochrome P450","volume":"43","author":"Rysz","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.118.083808_bib28","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.physbeh.2008.07.019","article-title":"The effects of metergoline and 8-OH-DPAT injections into arcuate nucleus and lateral hypothalamic area on feeding in female rats during the estrous cycle","volume":"95","author":"Steffens","year":"2008","journal-title":"Physiol Behav"},{"key":"10.1124\/dmd.118.083808_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1124\/mol.109.056705","article-title":"Sex differences in the expression of hepatic drug metabolizing enzymes","volume":"76","author":"Waxman","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib30","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1210\/me.2006-0007","article-title":"Growth hormone regulation of sex-dependent liver gene expression","volume":"20","author":"Waxman","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1124\/dmd.118.083808_bib31","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0026-895X(25)10535-X","article-title":"Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate","volume":"48","author":"Waxman","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.118.083808_bib32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0022-3565(24)36840-5","article-title":"Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats","volume":"282","author":"Willins","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.118.083808_bib33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0006-8993(87)90975-9","article-title":"Origin of serotonin innervation of the arcuate and ventromedial hypothalamic region","volume":"418","author":"Willoughby","year":"1987","journal-title":"Brain Res"},{"key":"10.1124\/dmd.118.083808_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0006-8993(87)91386-2","article-title":"Activation of serotonin receptors in the medial basal hypothalamus stimulates growth hormone secretion in the unanesthetized rat","volume":"404","author":"Willoughby","year":"1987","journal-title":"Brain Res"},{"key":"10.1124\/dmd.118.083808_bib35","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1517\/17425250902973703","article-title":"The brain dopaminergic system as an important center regulating liver cytochrome P450 in the rat","volume":"5","author":"W\u00f3jcikowski","year":"2009","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1124\/dmd.118.083808_bib36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2174\/138920011795016908","article-title":"The role of the nervous system in the regulation of liver cytochrome P450","volume":"12","author":"W\u00f3jcikowski","year":"2011","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.118.083808_bib37","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2174\/138920007781368872","article-title":"The regulation of liver cytochrome P450 by the brain dopaminergic system","volume":"8","author":"W\u00f3jcikowski","year":"2007","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.118.083808_bib38","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S1734-1140(13)71482-8","article-title":"Effect of antidepressant drugs on cytochrome P450 2C11 (CYP2C11) in rat liver","volume":"65","author":"W\u00f3jcikowski","year":"2013","journal-title":"Pharmacol Rep"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624077730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624077730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.118.083808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:52:29Z","timestamp":1739904749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624077730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0090955624077730"],"URL":"https:\/\/doi.org\/10.1124\/dmd.118.083808","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serotonin Receptors of 5-HT2 Type in the Hypothalamic Arcuate Nuclei Positively Regulate Liver Cytochrome P450 via Stimulation of the Growth Hormone\u2013Releasing Hormone\/Growth Hormone Hormonal Pathway","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.118.083808","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}